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Molecular bumpers and glues rewire GPCR signaling for next-generation medicines

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest receptors into precision tools - opening the door to a new generation of safer, smarter medicines.

31 Oct 2025

Scripps Research scientists receive NIH grant to unlock long-term HIV protection

Nearly 40 years after HIV was first identified, the virus continues its devastating march across the globe. Today, 38 million people live with HIV, and each year brings 1.5 million new infections and 650,000 more deaths-while nearly 10 million people still lack access to life-saving medicines.

31 Oct 2025

New method enhances precision in bionic limb movement interpretation

Despite enormous progress in the past two decades, the intentional control of bionic prostheses remains a challenge and the subject of intensive research.

31 Oct 2025

Sensory effects of flavanols trigger physiological responses in the brain

Astringency is a dry, puckering, rough, or sandpapery sensation in the mouth caused by plant-derived polyphenols.

31 Oct 2025

Studies identify complementary approaches to overcome drug resistance in KRAS G12C–mutant lung cancer

Two companion studies published in Cancer Research from scientists at Moffitt Cancer Center identify distinct but complementary approaches to overcoming drug resistance in KRAS G12C–mutant non-small cell lung cancer.

31 Oct 2025

19 NCAA women's college basketball coaches join hands to support women’s heart health

Both on the court and off, cardiovascular disease is the leading killer of women in the United States, taking the lives of more than 440,000 women each year, according to the American Heart Association, a relentless force changing the future of health for everyone everywhere.

30 Oct 2025

Advances in diagnosis and management of systemic light chain amyloidosis

Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

30 Oct 2025

Global Virus Network announces the addition of three new Centers of Excellence

The Global Virus Network (GVN), a coalition of leading medical virologists representing 80+ Centers of Excellence and Affiliates in 40+ countries, today announced the addition of three new Centers of Excellence: the USF Health Institute for Translational Virology and Innovation at the University of South Florida (USF) in Tampa, Florida, USA, the Department of Microbiology, Immunology and Parasitology at the Federal University of São Paulo (UNIFESP) in Brazil, and the Pathogen Research Centre (PaRC) at Western University in Canada.

30 Oct 2025

Merck partners with Promega to advance 3-D cell dug discovery technologies

Merck, a leading science and technology company, has entered into a partnership with Promega Corporation, a global life science solutions and service leader based in Madison, Wisconsin in the US, to co-develop novel technologies that advance drug screening and discovery.

From Merck 30 Oct 2025

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Glioblastoma (GBM), the most aggressive primary brain tumor, continues to portend a poor prognosis with median survival under two years, despite standard care involving surgery, radiation, and temozolomide chemotherapy.

30 Oct 2025

Scripps Research professor wins $3.2 million grant to unravel the mysteries of type 1 diabetes

Luc Teyton, professor in the Department of Immunology and Microbiology at Scripps Research, has received a five-year, $3.2 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to help answer how type 1 diabetes manifests and develop potential therapeutics to reverse or prevent the disease.

29 Oct 2025

Systematic analysis reveals psilocybin's impact on obsessive-compulsive behaviors

A systematic review published today in Psychedelics by Mr. James Gattuso and colleagues at the Florey Institute of Neuroscience and Mental Health synthesizes clinical and preclinical evidence on psilocybin's effects on obsessive-compulsive behaviors, revealing consistent therapeutic potential across human patients and validated animal models.

29 Oct 2025

AI indelibly transforms solid tumor drug development

Artificial intelligence (AI) is fundamentally reshaping the landscape of solid tumor (ST) drug development.

29 Oct 2025

Hydroxytyrosol from olives shows new promise as a brain-protective compound

This review highlights hydroxytyrosol's role as a neuroprotective agent, activating key pathways for mental and vascular health through olive-derived compounds.

29 Oct 2025

Emerging neuromodulation techniques for treatment-resistant obsessive-compulsive disorder

In a peer-reviewed article published today in Brain Medicine, a European research team presents a focused review of emerging neuromodulation techniques for treatment-resistant obsessive-compulsive disorder (OCD).

28 Oct 2025

Mount Sinai receives $4.5 million grant to investigate neural mechanisms underlying bipolar disorder

The Icahn School of Medicine at Mount Sinai is pleased to announce it has received a three-year, $4.5 million grant from BD2: Breakthrough Discoveries for thriving with Bipolar Disorder to investigate the neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.

28 Oct 2025

Using AI and citizen science for vector-borne disease surveillance

Researchers from the University of South Florida have used artificial intelligence and citizen science to identify what may be the first specimen of Anopheles stephensi - an invasive and deadly malaria-carrying mosquito - ever detected in Madagascar.

28 Oct 2025

CZI and NVIDIA collaborate to accelerate life science research through virtual cell models

Today, the Chan Zuckerberg Initiative (CZI) and NVIDIA announced an expanded collaboration to accelerate life science research by driving development and adoption of virtual cell models through tools, data, models, and benchmarks delivered through CZI's virtual cells platform (VCP).

28 Oct 2025

Scripps Research wins $4 million CIRM grant to develop novel platform for neurodevelopmental disorders

Most people are born with two functioning copies of each gene-one inherited from each parent. In many cases, having just one working copy is enough for the body to function normally.

28 Oct 2025

Fogarty Innovation and CRF unite to accelerate breakthroughs in cardiovascular medicine

After several years of close collaboration and a relationship rooted in mutual respect and shared vision, Fogarty Innovation is coming together with the Cardiovascular Research Foundation® (CRF®) to create a unified platform for advancing transformative healthcare technologies.

27 Oct 2025

Next Generation News and Research

Molecular bumpers and glues rewire GPCR signaling for next-generation medicines

Scripps Research scientists receive NIH grant to unlock long-term HIV protection

New method enhances precision in bionic limb movement interpretation

Sensory effects of flavanols trigger physiological responses in the brain

Studies identify complementary approaches to overcome drug resistance in KRAS G12C–mutant lung cancer

19 NCAA women's college basketball coaches join hands to support women’s heart health

Advances in diagnosis and management of systemic light chain amyloidosis

Global Virus Network announces the addition of three new Centers of Excellence

Merck partners with Promega to advance 3-D cell dug discovery technologies

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Scripps Research professor wins $3.2 million grant to unravel the mysteries of type 1 diabetes

Systematic analysis reveals psilocybin's impact on obsessive-compulsive behaviors

AI indelibly transforms solid tumor drug development

Hydroxytyrosol from olives shows new promise as a brain-protective compound

Emerging neuromodulation techniques for treatment-resistant obsessive-compulsive disorder

Mount Sinai receives $4.5 million grant to investigate neural mechanisms underlying bipolar disorder

Using AI and citizen science for vector-borne disease surveillance

CZI and NVIDIA collaborate to accelerate life science research through virtual cell models

Scripps Research wins $4 million CIRM grant to develop novel platform for neurodevelopmental disorders

Fogarty Innovation and CRF unite to accelerate breakthroughs in cardiovascular medicine

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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