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Researchers uncover distinct cell vulnerabilities in Alzheimer’s progression with novel multiomics approach

Researchers used single-cell and spatial genomics to map cell-type-specific changes in the middle temporal gyrus, identifying distinct disease phases in Alzheimer’s progression.

16 Oct 2024

Gene editing restores treatment sensitivity in melanoma

In a potential advance for melanoma patients, researchers at ChristianaCare’s Gene Editing Institute have used CRISPR gene editing tools to disable a gene mutation often seen in aggressive forms of this dangerous skin cancer that renders promising treatments ineffective.

16 Oct 2024

Historical review reveals French contributions to depression research

In an era where mental health awareness is at the forefront of public discourse, a new historical review is shedding light on the often-overlooked French contributions to our understanding of depression.

16 Oct 2024

Excess body fat significantly increases risk of postmenopausal breast cancer

Around 40% of postmenopausal hormone positive breast cancer cases may be linked to excess body fat, suggests Spanish research published online in the Journal of Epidemiology & Community Health.

16 Oct 2024

Genetic insights transform treatment for children with developmental disorders

Thousands of children with severe developmental disorders have benefited from more targeted treatments and support with genetic insights from the large-scale Deciphering Developmental Disorders (DDD) study, finds a new study.

15 Oct 2024

New study reveals mechanism of inflammation in lupus

Immune cells called monocytes produce a key inflammatory protein called interleukin-1 beta (IL-1β) through an unconventional pathway in patients with systemic lupus erythematosus, commonly referred to as lupus, according to a new study by Weill Cornell Medicine investigators.

15 Oct 2024

Genetics identified as key factor in gout development

A major international study has found gout is a chronic illness where genetics is a major cause, rather than lifestyle choices of the sufferer.

15 Oct 2024

Study reveals how Alzheimer's may cause brain damage in two distinct phases

Alzheimer's disease may damage the brain in two distinct phases, based on new research funded by the National Institutes of Health (NIH) using sophisticated brain mapping tools.

15 Oct 2024

Experimental drug RK-33 shows promise in treating breast cancer bone metastasis

In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses.

15 Oct 2024

SU2C announces grants to support cutting-edge research in a variety of cancers

Stand Up To Cancer (SU2C) today announced grants to several teams of leading cancer investigators in support of cutting-edge research in a variety of cancers including head and neck, pediatric, pancreatic, breast, rectal and gastro-esophageal cancers, as well as research focused on how the microbiome communicates with the immune system.

15 Oct 2024

Mayo Clinic scientists develop mini brain models to study Lewy body dementia

Lewy body dementia (LBD) is a progressive neurodegenerative disease that shares traits with both Parkinson's disease and Alzheimer's disease but can be more difficult to diagnose.

15 Oct 2024

Genomic findings shed light on ancient Japanese population origins

A joint research group led by Jonghyun Kim and Jun Ohashi of the University of Tokyo has demonstrated that the majority of immigration to the Japanese Archipelago in the Yayoi and Kofun periods (between 3000 BCE and 538 CE) came from the Korean Peninsula.

14 Oct 2024