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A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

A recent PLoS ONE study detected neutralizing nanobodies against SARS-CoV-2 from nanobody phage display libraries and via in vitro and ex vivo high-throughput screenings.

2 Sep 2022

Study shows encouraging therapeutic options for patients with relapsed multiple myeloma

Mount Sinai researchers have published results that show encouraging therapeutic options for patients with the blood cancer multiple myeloma after first-line treatment with bispecific antibodies fails.

1 Sep 2022

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

The current study focused on the ability of this nmAb to neutralize Delta, Omicron, and other VOCs, as well as its efficacy when given by the intranasal route in an animal model.

1 Sep 2022

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

In a new study, researchers assessed the effects of N501Y mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein on binding to angiotensin-converting enzyme-2 (ACE-2).

1 Sep 2022

Molecular fate-mapping of antibodies shows effects of antigenic imprinting

In a new study, researchers developed a molecular fate-mapping method for differential detection of antibodies derived from specific B cell clones.

1 Sep 2022

The most recent evidence about phylogenesis, pathogenesis, prevention, and treatment for monkeypox

A new review sheds light on the origins of this virus and recently acquired knowledge about its disease mechanism and the preventive and therapeutic measures appropriate in this situation.

31 Aug 2022

How effective was the Shanghai lockdown policy compared with that of other countries?

A recent study aimed to fill this gap in research by evaluating the impact of strict lockdown measures on SARS-CoV-2 Omicron transmission in Shanghai between March and April 2022.

31 Aug 2022

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Patients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer markers of immune cell exhaustion, and distinct changes to immune cell populations were more likely to have longer progression-free survival (PFS) after treatment with BCMA-targeted T-cell therapy.

30 Aug 2022

Vitamin D mediates crosstalk between COVID-19 and osteoporosis

Researchers identify and characterize the targets of Vit D on COVID-19 and osteoporosis.

30 Aug 2022

What is the infectivity of SARS-CoV-2 Omicron BA.2.75 variant?

Researchers recently assessed the infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2.75 variant compared to preexisting variants.

30 Aug 2022

Breast MRI may help stratify the risk of second breast cancer

Breast tissue features apparent on MRI are linked with future second breast cancer risk in women with a personal history of breast cancer, according to a study published in Radiology, a journal of the Radiological Society of North America (RSNA).

30 Aug 2022

The effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike RBD to the human receptor hACE2

Researchers performed a structural bioinformatics analysis to evaluate the binding energy of the SARS-CoV-2 Omicron variants of concern spike protein receptor-binding domain to human angiotensin-converting enzyme 2 receptor compared to other VOCs.

30 Aug 2022

Researchers report the exceptional binding and neutralizing potency of an ACE2 decoy against SARS-CoV-2 variants

Researchers explored the activity of an ACE2 decoy against SARS-CoV-2 Omicron variant.

30 Aug 2022

Exploration of glycan shield structure of sarbecoviruses provides new insights into developing pan-coronavirus vaccines

A new study explored the glycan shield diversity of sarbecoviruses, furthering the knowledge for developing broad-range pan-coronavirus vaccines.

30 Aug 2022

Study reveals a 'stealing' mechanism that contributes to antibody diversity

A few years ago, Professor Kathrin de la Rosa and her colleagues in the lab of the Swiss immunologist Antonio Lanzavecchia made an unusual discovery.

29 Aug 2022

Researchers discover new therapeutic target for triple-negative breast cancer

Breast cancer is categorized into three major subtypes: hormone receptor-positive, HER2-positive, and triple-negative.

29 Aug 2022

Oncolytic viruses boost the immune capacity to effectively target and destroy cancer cells

The immune system has evolved to safeguard the body from a wildly diverse range of potential threats. Among these are bacterial diseases, including plague, cholera, diphtheria and Lyme disease, and viral contagions such as influenza, Ebola virus and SARS CoV-2.

29 Aug 2022

FAU and Tel Aviv researchers receive grant to tackle Alzheimer’s-related mood disorders

Alzheimer's disease (AD) is the most common type of dementia affecting an estimated 6.3 million Americans age 65 and older. Without the development of medical breakthroughs to prevent, treat, slow or cure AD that number could grow to 13.8 million by 2060.

29 Aug 2022

High-throughput proteomics reveals pregnancy-specific responses to COVID-19

Researchers evaluated pregnancy-specific responses to SARS-CoV-2 infection.

29 Aug 2022

How does the maternal immune response balance SARS-CoV-2 antiviral responses with transplacental transfer of protection to the fetus?

Researchers found that in SARS-CoV-2 maternal infection, the balance between antiviral response and transplacental transfer of humoral and cellular protection relies on maternal IL-6 and IL10.

29 Aug 2022

Receptor News and Research

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

Study shows encouraging therapeutic options for patients with relapsed multiple myeloma

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

Molecular fate-mapping of antibodies shows effects of antigenic imprinting

The most recent evidence about phylogenesis, pathogenesis, prevention, and treatment for monkeypox

How effective was the Shanghai lockdown policy compared with that of other countries?

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Vitamin D mediates crosstalk between COVID-19 and osteoporosis

What is the infectivity of SARS-CoV-2 Omicron BA.2.75 variant?

Breast MRI may help stratify the risk of second breast cancer

The effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike RBD to the human receptor hACE2

Researchers report the exceptional binding and neutralizing potency of an ACE2 decoy against SARS-CoV-2 variants

Exploration of glycan shield structure of sarbecoviruses provides new insights into developing pan-coronavirus vaccines

Study reveals a 'stealing' mechanism that contributes to antibody diversity

Researchers discover new therapeutic target for triple-negative breast cancer

Oncolytic viruses boost the immune capacity to effectively target and destroy cancer cells

FAU and Tel Aviv researchers receive grant to tackle Alzheimer’s-related mood disorders

High-throughput proteomics reveals pregnancy-specific responses to COVID-19

How does the maternal immune response balance SARS-CoV-2 antiviral responses with transplacental transfer of protection to the fetus?

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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