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Celsion signs definitive asset purchase agreement to acquire EGEN

Celsion Corporation (Celsion) (NASDAQ: CLSN), an oncology drug development company, and EGEN, Inc. (EGEN), a privately-held biopharmaceutical company focused on the development of nucleic acid-based therapeutics for the treatment of cancer and other difficult to treat diseases, today announced the signing of a definitive asset purchase agreement in which Celsion will acquire substantially all of the assets of EGEN, including its Phase Ib DNA-based immunotherapy product candidate EGEN-001 and its therapeutic platform technologies, TheraPlas™ for delivery of DNA and mRNA, TheraSilence™ for delivery of RNA, and RAST™ for Cell Enabled Expression and Secretion of RNA.

10 Jun 2014

Inovio evaluates responses of immunotherapy product in treating HPV linked head and neck cancer

Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) today announced it has initiated a phase I/IIa clinical trial to evaluate safety, immunogenicity and clinical responses of its immunotherapy product, INO-3112, in treating human papillomavirus (HPV)- associated head and neck cancer.

10 Jun 2014

Chronic sleep loss can cause certain neurotoxic molecules to permeate into brain tissue

The longer the insomnia, junctions of cerebral blood vessels begin to degrade. In search of the answer to why do we sleep, research conducted at the Mexican Metropolitan Autonomous University (UAM) revealed that chronic sleep loss can cause certain neurotoxic molecules, which normally circulate in the blood, to be transported to the central nervous system and interfere with the function of neurons.

10 Jun 2014

Findings add surprising new dimension to understanding of antibody repertoires

As elite soldiers of the body's immune response, B cells serve as a vast standing army ready to recognize and destroy invading antigens, including infections and cancer cells. To do so, each new B cell comes equipped with its own highly specialized weapon, a unique antibody protein that selectively binds to specific parts of the antigen.

10 Jun 2014

Research on viral RNA may help scientists develop treatments against infectious diseases

In an article published in the scientific journal Nature, a University of Colorado School of Medicine researcher and colleagues explain how RNA molecules found in certain viruses mimic the shape of other molecules as part of a strategy to 'hijack' the cell and make more viruses.

10 Jun 2014

Researchers reveal mysterious behavior of individual cells using radioluminescence microscopy

With a new molecular imaging system powerful enough to peer down to 20-micrometer resolution, researchers can now use radioluminescence to examine the characteristics of single, unconnected cells. The result is a fascinating picture of diversity among cells previously assumed to behave the same, revealed researchers at the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.

10 Jun 2014

Researchers solve structure of key protein that drives DNA copying in plasmids

Staph infections that become resistant to multiple antibiotics don't happen because the bacteria themselves adapt to the drugs, but because of a kind of genetic parasite they carry called a plasmid that helps its host survive the antibiotics.

10 Jun 2014

Protein may be key to maintaining health of aging blood stem cells

A protein may be the key to maintaining the health of aging blood stem cells, according to work by researchers at the Icahn School of Medicine at Mount Sinai recently published online in Stem Cell Reports.

10 Jun 2014

Combination of novel molecular imaging techniques can help predict spread of cancer, patient survival

A simple noninvasive blood test matched with state-of-the-art molecular imaging of individual cells could help oncologists understand their patients' chances of survival, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.

10 Jun 2014

African-American women at increased risk for deadlier breast cancers, study finds

A research study led by cancer specialists at MedStar Washington Hospital Center found that African-American women frequently present with biologically less favorable subtypes of breast cancer.

10 Jun 2014

Antibody-based molecular imaging agent offers hope for novel breast cancer treatments

For years researchers have been developing molecular imaging techniques that visualize hormonally active breast cancer cells-specifically those testing positive for human epidermal growth factor receptor 2 (HER2).

10 Jun 2014

JDRF-funded researchers find that beta cell stress may play vital role in the onset of type 1 diabetes

In the healthy pancreas of someone without type 1 diabetes (T1D), the hormone insulin (essential for turning food into energy) is produced, stored, and released in a normal "factory-like" process within pancreatic beta cells in response to glucose in the diet.

10 Jun 2014

Protein-kinase interactions offer a new way to fight antimalarial drug resistance

When it comes to the emergence of antimalarial drug resistance, it's not a question of 'if' but 'when'. In order to keep up with the quickly evolving Plasmodium parasite - the cause of malaria - new ways to treat and control the disease must be found.

9 Jun 2014

Scientific images of blood, brain, bacteria are on display at Washington Dulles International Airport

Stunning scientific images of blood, brain, bacteria, viruses and more, enlarged by as much as 50,000 times, are on display in an exhibit called "Life: Magnified," on view through November 2014 at Washington Dulles International Airport's Gateway Gallery.

9 Jun 2014

Rubicon signs agreements with 7 distributors to expand availability of DNA library preparation products

Rubicon Genomics, Inc., today announced that it signed agreements with seven distributors in Europe to expand the availability of its leading DNA library preparation products, including ThruPLEX®-FD Prep Kit and PicoPLEX™ DNA-seq Kit for use with Illumina® next-generation sequencing (NGS) systems and PicoPLEX™ WGA Kit for use on arrays, and to prepare for new product launches planned for the coming months.

9 Jun 2014

Sequenom signs national agreement to provide MaterniT21 PLUS LDT

Sequenom, Inc., a life sciences company providing innovative testing and genetic analysis solutions, announced today its wholly owned subsidiary, Sequenom Laboratories, has signed a national agreement with a leading health insurance company covering 13 million people throughout the United States, to provide the MaterniT21™ PLUS laboratory-developed test (LDT).

9 Jun 2014

Researchers identify critical weakness of invasive cancer cells

Metastatic cancer cells, which can migrate from primary tumors to seed new malignancies, have thus far been resistant to the current arsenal of anticancer drugs.

9 Jun 2014

Research finding paves way for targeted approaches to treating cancer patients

Twelve years ago, UNC School of Medicine researcher Brian Strahl, PhD, found that a protein called Set2 plays a role in how yeast genes are expressed - specifically how DNA gets transcribed into messenger RNA. Now his lab has found that Set2 is also a major player in DNA repair, a complicated and crucial process that can lead to the development of cancer cells if the repair goes wrong.

9 Jun 2014

Accelera signs agreement to complete preclinical studies of Cellectis' UCART19

Cellectis, a leader of allogeneic CAR T-cell therapies, and Accelera, the preclinical CRO (Contract Research Organisation) within the Nerviano Medical Sciences Group, recently signed an agreement to complete the preclinical studies of Cellectis' advanced product candidate, UCART19.

9 Jun 2014

New class of genetic switches gives clues on stem cell development

Case Western Reserve researchers have discovered landmarks within pluripotent stem cells that guide how they develop to serve different purposes within the body.

9 Jun 2014

B Cell News and Research

Celsion signs definitive asset purchase agreement to acquire EGEN

Inovio evaluates responses of immunotherapy product in treating HPV linked head and neck cancer

Chronic sleep loss can cause certain neurotoxic molecules to permeate into brain tissue

Findings add surprising new dimension to understanding of antibody repertoires

Research on viral RNA may help scientists develop treatments against infectious diseases

Researchers reveal mysterious behavior of individual cells using radioluminescence microscopy

Researchers solve structure of key protein that drives DNA copying in plasmids

Protein may be key to maintaining health of aging blood stem cells

Combination of novel molecular imaging techniques can help predict spread of cancer, patient survival

African-American women at increased risk for deadlier breast cancers, study finds

Antibody-based molecular imaging agent offers hope for novel breast cancer treatments

JDRF-funded researchers find that beta cell stress may play vital role in the onset of type 1 diabetes

Protein-kinase interactions offer a new way to fight antimalarial drug resistance

Scientific images of blood, brain, bacteria are on display at Washington Dulles International Airport

Rubicon signs agreements with 7 distributors to expand availability of DNA library preparation products

Sequenom signs national agreement to provide MaterniT21 PLUS LDT

Researchers identify critical weakness of invasive cancer cells

Research finding paves way for targeted approaches to treating cancer patients

Accelera signs agreement to complete preclinical studies of Cellectis' UCART19

New class of genetic switches gives clues on stem cell development

Immunology eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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