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Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

Clinical trial tests effectiveness of chemotherapy after surgery for pancreatic neuroendocrine tumors

A new clinical trial is testing the effectiveness of chemotherapy treatment following surgery for a subset of pancreatic cancer patients.

19 May 2023

Novel gene-editing strategy harnesses an unusual protective ability to eliminate HIV-1 infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

19 May 2023

Valbenazine improves chorea associated with Huntington's disease

The drug valbenazine statistically improves chorea, a movement disorder commonly associated with Huntington's disease, when compared to a placebo, according to a recent international study led by UTHealth Houston researcher Erin Furr Stimming, MD, who served as principal investigator on behalf of the KINECT-HD Huntington Study Group.

19 May 2023

Tirzepatide improves body composition across a range of adult age groups, study shows

A new analysis of SURMOUNT-1, the first Phase 3 study of tirzepatide in adults for chronic weight management shows that tirzepatide improves body composition across a range of adult age groups.

19 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

Both vaccine strain and adjuvant selection are critical elements for improving the breadth of protective immunity against enterovirus D68

Researchers demonstrated the production of cross-clade neutralizing antibodies in response to EV-D68.

19 May 2023

Bouncing towards comfort: Birthing and peanut balls proven safe and effective for labor pain relief

Scientists evaluate the safety and efficacy of birthing balls and peanut balls as nonpharmacologic interventions during labor. Findings indicate that birthing balls reduce maternal pain, and peanut balls decrease the duration of the first stage of labor, suggesting their effectiveness and safety as adjuncts to labor management techniques.

18 May 2023

Food preservative nisin: A gut game changer that safely alters microbiome composition

Nisin, a powerful bacteriocin, influences the gut microbiota and its functionality by modulating the abundance of specific bacterial groups and altering short-chain fatty acid synthesis.

18 May 2023

Increasing rates of induction of labor of pregnant women in the UK may have unintended consequences

A new study suggests that increasing rates of induction of labour (IOL) of pregnant women and people in the UK, without considering the accompanying, real-world impact on staffing workloads and patient care, may have unintended consequences.

18 May 2023

UVA Cancer Center receives $250,000 to develop innovative new approach to treating leukemia

Children's Cancer Research Fund has awarded $250,000 to an innovative new approach to treating leukemia – blood cancer – being developed at UVA Cancer Center.

18 May 2023

Study claims that mask-wearing is still as necessary in healthcare settings

Researchers advocated that it was not the (right) time to stop using masks in healthcare settings.

18 May 2023

Study examines safety and efficacy of made-to-fade tattoos for medical markings

Researchers at Henry Ford Health - one of the nation's leading integrated academic medical institutions - in collaboration with Ephemeral Tattoo, have conducted a study on the safety and efficacy of made-to-fade tattoos for medical markings.

17 May 2023

Clinical trial shows efficacy and safety of brepocitinib for treating adults with psoriatic arthritis

Brepocitinib is an oral drug that inhibits certain enzymes involved in inflammation - called tyrosine kinase 2 and Janus kinase 1 - and is being tested for the treatment of several immunological diseases.

17 May 2023

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Researchers generated six human monoclonal antibodies that prevented infection.

17 May 2023

Updated evidence suggests that masks may be associated with a reduction in risk for SARS-CoV-2 infection

Researchers presented updated evidence of the effectiveness of masks in preventing SARS-CoV-2.

17 May 2023

Are masks effective in the protection against COVID-19?

Researchers discussed the efficacy of masks in preventing coronavirus disease 2019 (COVID-19).

17 May 2023

Cancer patients can initiate SARS-CoV-2 vaccination three months after bone marrow transplant

Patients with cancer whose immune systems are being supported or rebuilt by bone marrow transplantation should begin receiving vaccines for protection against SARS-CoV-2 three months post-transplant, according to a large, prospective, observational study led collaboratively by the Center for International Blood and Marrow Transplant Research, the Blood & Marrow Transplant Clinical Trials Network and Fred Hutchinson Cancer Center.

16 May 2023

LabGenius Debuts T-cell Engager Optimisation Capability That Yields Molecules with >400-fold Tumour Killing Selectivity Versus Clinical Benchmark

Through a recent platform demonstration project, LabGenius’ machine learning-driven lead optimisation capability delivered dozens of novel T-cell engagers with best-in-class killing selectivity.

From LabGenius 16 May 2023

Obesity undermines COVID-19 vaccines

Researchers examine the impact of obesity on COVID-19 outcomes and the effectiveness of vaccines in individuals with obesity. Using data from Scotland, the study explores the relationship between body mass index (BMI) and hospitalization/mortality due to COVID-19.

15 May 2023

Efficacy News and Research

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Clinical trial tests effectiveness of chemotherapy after surgery for pancreatic neuroendocrine tumors

Novel gene-editing strategy harnesses an unusual protective ability to eliminate HIV-1 infection

Valbenazine improves chorea associated with Huntington's disease

Tirzepatide improves body composition across a range of adult age groups, study shows

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Both vaccine strain and adjuvant selection are critical elements for improving the breadth of protective immunity against enterovirus D68

Bouncing towards comfort: Birthing and peanut balls proven safe and effective for labor pain relief

Food preservative nisin: A gut game changer that safely alters microbiome composition

Increasing rates of induction of labor of pregnant women in the UK may have unintended consequences

UVA Cancer Center receives $250,000 to develop innovative new approach to treating leukemia

Study claims that mask-wearing is still as necessary in healthcare settings

Study examines safety and efficacy of made-to-fade tattoos for medical markings

Clinical trial shows efficacy and safety of brepocitinib for treating adults with psoriatic arthritis

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Updated evidence suggests that masks may be associated with a reduction in risk for SARS-CoV-2 infection

Are masks effective in the protection against COVID-19?

Cancer patients can initiate SARS-CoV-2 vaccination three months after bone marrow transplant

LabGenius Debuts T-cell Engager Optimisation Capability That Yields Molecules with >400-fold Tumour Killing Selectivity Versus Clinical Benchmark

Obesity undermines COVID-19 vaccines

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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