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Genetic mutation associated with perceived inadequate milk supply in mothers

Leading health care organizations recommend exclusive breastfeeding for six months after birth, yet some mothers report stopping due to a perceived lack of milk supply.

23 Feb 2022

Study proposes SARS-CoV-2-encoded peptide presented by HLA-E may suppress inhibition of natural killer cells

A recent study reported the abrogation of inhibition of the NK cells by a SARS-CoV-2-encoded protein presented by HLA-E.

23 Feb 2022

SARS-CoV 2 Omicron prevalent in vaccine breakthrough cases in Bahia, Brazil

In a recent study posted to the medRxiv* pre-print server, researchers performed genomic monitoring to estimate the magnitude and range of the different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in SARS-CoV-2 reinfection cases among fully vaccinated individuals in Salvador, Bahia, Brazil.

23 Feb 2022

Study investigates the prevalence risk of familial dilated cardiomyopathy

Idiopathic dilated cardiomyopathy (DCM), the most common type of heart failure in the United States, was found to have a familial etiology in 30 percent of individuals diagnosed with DCM, and the overall risk for a family member of developing DCM was nearly 20 percent by the age of 80, according to a family-based, cross-sectional study published in JAMA.

22 Feb 2022

CD91 receptor promotes SARS-CoV-2 infection

researchers find that LRP1/CD91 is a leading molecule in virus-host cell interactions that causes infection by many RNA viruses.

22 Feb 2022

TGen and Deepcell collaborate to employ AI-based technology to classify and isolate diseased cells

The Translational Genomics Research Institute, an affiliate of City of Hope, is partnering with a Silicon Valley firm to become one of the first research institutes in the world to employ a new Artificial Intelligence-powered imaging and sorting technology to classify and isolate individual diseased cells.

22 Feb 2022

SARS CoV-2 in deer from Pennsylvania sampled during fall and winter 2021

Researchers examined whether SARS-CoV-2-infected white-tailed deer could be the new animal reservoir with the potential to spillback new SARS-CoV-2 variants into humans.

22 Feb 2022

Monitoring rise of SARS-CoV-2 variants in wastewater using genome sequencing

Researchers conduct genomic wastewater surveillance of SARS-CoV-2 following the emergence of the Alpha and Delta variants in the United Kingdom.

21 Feb 2022

The logic that controls gene regulation in human cells discovered

A research group at the University of Helsinki has discovered the logic that controls gene regulation in human cells. In the future, this new knowledge can be applied to, for example, investigating cancers and other genetic diseases.

21 Feb 2022

Researchers unravel essential final steps in the production of mRNA

Proteins need to interact in a complex manner for a so-called "messenger RNA" (mRNA) to be created in human cells from a precursor molecule. mRNA provides a blueprint for proteins; the first vaccines against the coronavirus are also based on mRNAs.

21 Feb 2022

Molecular characteristics of SARS-CoV-2 variants enabling antibody escape

A new review paper published in PLoS Pathogens discusses the new variants and the structural mechanism underlying antibody-mediated neutralization as well as mutational antibody escape.

21 Feb 2022

Comparing the genomic landscapes of SARS-CoV-2 isolated from animal species relative to that in humans

A recent study identified six candidate mutations in the SARS-CoV-2 genome adaptive to animal hosts.

21 Feb 2022

First study in North America uses genetic testing to identify people at risk of heart disease

Dignity Health in Arizona is launching the first research study in North America in which genetic testing is used to identify men and women at risk of developing heart disease based on the makeup of their DNA.

21 Feb 2022

N-glycosylation blockers reduce SARS-CoV-2 infection

A new Virology study shows that the N-glycosylation pattern of SARS-CoV-2 is crucial to normal spike activity.

20 Feb 2022

Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

A new study explains how SARS-CoV-2 adapts its immunogenicity to the immune response of the host.

20 Feb 2022

T-cell responses linked with protection from SARS-CoV-2 infection in vaccinated individuals with or without cancer

T-cell responses directed against the receptor-binding domain of the SARS-CoV-2 spike protein were associated with protection from SARS-CoV-2 infection in vaccinated individuals with or without cancer, with lower T-cell responses observed in patients with blood cancers.

18 Feb 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

Omicron outbreak in an indoor convention in New York

A recent report published by the CDC, USA, has demonstrated one of the earliest outbreaks of omicron infection in the US.

18 Feb 2022

Study reports a highly attenuated SARS-CoV-2 that could serve as a live-attenuated vaccine platform

The research showed a highly attenuated SARS-CoV-2 strain that might be used as a live-attenuated vaccine platform and a BSL-2 experimental system.

18 Feb 2022

Research shows alterations in transfer RNAs at the epigenetic level in cancer

A recently published paper in the journal Molecular Cancer by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Genetics Chairman at the University of Barcelona, shows that transfer RNAs for certain amino acids are altered at the epigenetic level in some types of cancer, expressing it in an exaggerated manner in some cases and being deficient in others.

17 Feb 2022