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Jumping genes: a marker for early cancer diagnosis? An interview with Dr Kazazian

In the genome of every human being, there are about 80-100 active LINE-1s that are capable of mobilizing by a copy and paste mechanism to a new location in the genome.

6 Oct 2015

New UV-Vis spectrophotometer simplifies sample quality decisions

Life scientists who work with DNA, RNA and proteins can make educated decisions about sample suitability in experiments using a standalone, microvolume spectrophotometer for accurate quantitation and purity measurements to ensure downstream application success.

From Thermo Fisher Scientific Inc. 6 Oct 2015

Getting right nutrition throughout life can help protect against osteoporosis in old age

Whether you're young or old, the right nutrition can make a difference to your bone health and influence your ability to live an independent, mobile, fracture-free life into your more senior years. That's the key message of a new scientific review published today in the journal 'Osteoporosis International' by leading bone and nutrition experts, in anticipation of World Osteoporosis Day on October 20.

6 Oct 2015

Finding could lead to potential new treatment for patients with autoimmune diseases

Antibodies protect the body against diseases - but can also harm their own organism if the reactions are misdirected. Researchers from the University of Zurich have now discovered that a particular sugar in the antibodies determines whether one of the body's own cells is destroyed or not. This result could lead to new treatment possibilities for patients with autoimmune diseases.

6 Oct 2015

IU-led scientists discover new gene that increases Alzheimer's disease risk

In a newly published study, a multi-institutional team led by scientists at the Indiana University School of Medicine have discovered an immune system gene associated with higher rates of amyloid plaque buildup in the brains of Alzheimer's patients and older adults at risk for the disease.

6 Oct 2015

NIH-funded researchers test new gene therapy to improve visual function in mice

Researchers funded by the National Institutes of Health have developed a novel mouse model for the vision disorder Leber hereditary optic neuropathy (LHON), and found that they can use gene therapy to improve visual function in the mice. LHON is one of many diseases tied to gene mutations that damage the tiny energy factories that power our cells, called mitochondria.

6 Oct 2015

Sonic hedgehog gene maintains normal physiological state and repair process of adult lungs

The whimsically named sonic hedgehog gene, best known for controlling embryonic development, also maintains the normal physiological state and repair process of an adult healthy lung, if damaged, according to new research from the Perelman School of Medicine at the University of Pennsylvania published online this week in Nature in advance of the print edition.

6 Oct 2015

New smartphone-based device can reliably perform molecular diagnoses at low cost

NIBIB-funded researchers at the Massachusetts General Hospital have developed a smartphone-based device that can reliably carry out molecular diagnoses in under an hour for approximately two dollars per patient. The device could enable point-of-care cancer diagnostics in low- to middle-income or remote areas, which often have high rates of mortality from cancer due to missed opportunities for treatment.

6 Oct 2015

U of T study provides hope for treating ALS and FTD

It's the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but until now scientists weren't sure how a specific gene caused these devastating diseases. Now researchers from the University of Toronto are one step closer to solving this incredibly complex puzzle, offering hope for treatment.

6 Oct 2015

Novel computational strategy may help identify genetic variants that cause disease in children

The team behind the Deciphering Developmental Disorders (DDD) Study, one of the world's largest nationwide rare disease genome-wide sequencing initiatives, have developed a novel computational approach to identify genetic variants that cause disease in young children.

6 Oct 2015

Paradigm failure is primary reason for lack of progress in cancer research, says cancer biologist

A recent publication, which received sustained media attention, claimed that most cancers are just “bad luck”. Its authors stated that only about one-third of cancer mutations are caused by known lifestyle or environmental factors.

6 Oct 2015

Targeting protein used by tumors to help detect food supplies could restrict cancerous cells' ability to grow

Oxford University researchers have identified a protein used by tumours to help them detect food supplies. Initial studies show that targeting the protein could restrict cancerous cells' ability to grow.

6 Oct 2015

Genetic polymorphisms may serve as prognostic markers for lung cancer

Genetic polymorphisms associated with cancer progression lead to variations in gene expression and may serve as prognostic markers for lung cancer. Researchers at the Hiroshima University and Saitama Medical University found that in patients with lung cancer, a single nucleotide polymorphism (SNP) may regulate gene and protein expression and be associated with poor prognosis.

6 Oct 2015

Nivolumab, ipilimumab duo effective in poor prognosis advanced melanoma patients

Subgroups of advanced melanoma patients with a poor prognosis derive a progression-free survival benefit from the combination of nivolumab and ipilimumab, according to research presented at the European Cancer Congress in Vienna, Austria.

5 Oct 2015

Researchers identify role of microglia during early stages of Alzheimer's disease

For the first time, researchers have determined how toxic tau fibrils spread by the help of brain immune cells called microglia during the early stages of Alzheimer's disease (AD). The discovery of this new pathway may lead to a therapeutic target for AD, one that has not been previously identified.

5 Oct 2015

Clinical data from spinal muscular atrophy program presented at 20th International WMS Congress

PTC Therapeutics, Inc., today announced that clinical data from the company's joint development program with Roche and the SMA Foundation in spinal muscular atrophy (SMA) were presented at the 20th International Congress of the World Muscle Society (WMS) in Brighton, U.K.

5 Oct 2015

Beta-catenin shows treatment target potential for TKI-resistant CML

Nuclear β-catenin could be a treatment target for patients whose chronic myeloid leukaemia is resistant to tyrosine kinase inhibitors independent of additional BCR–BL1 mutations, US researchers suggest.

1 Oct 2015

Experimental drug shows promise in mice with multiple sclerosis

An experimental drug originally identified in a National Cancer Institute library of chemical compounds as a potential therapy for brain and basal cell cancers improves the symptoms of mice with a form of the debilitating neurological disorder multiple sclerosis (MS), according to new research from NYU Langone Medical Center.

1 Oct 2015

Two studies identify promising new anti-retroviral strategy to combat HIV-1

A pair of studies by researchers at the University of Massachusetts Medical School, the University of Trento in Italy, and the University of Geneva in Switzerland, point to a promising new anti-retroviral strategy for combating HIV-1.

1 Oct 2015

Study suggests link between human endogenous retroviral genes and ALS

Scientists at the National Institutes of Health discovered that reactivation of ancient viral genes embedded in the human genome may cause the destruction of neurons in some forms of amyotrophic lateral sclerosis (ALS).

1 Oct 2015

G Protein News and Research

Jumping genes: a marker for early cancer diagnosis? An interview with Dr Kazazian

New UV-Vis spectrophotometer simplifies sample quality decisions

Getting right nutrition throughout life can help protect against osteoporosis in old age

Finding could lead to potential new treatment for patients with autoimmune diseases

IU-led scientists discover new gene that increases Alzheimer's disease risk

NIH-funded researchers test new gene therapy to improve visual function in mice

Sonic hedgehog gene maintains normal physiological state and repair process of adult lungs

New smartphone-based device can reliably perform molecular diagnoses at low cost

U of T study provides hope for treating ALS and FTD

Novel computational strategy may help identify genetic variants that cause disease in children

Paradigm failure is primary reason for lack of progress in cancer research, says cancer biologist

Targeting protein used by tumors to help detect food supplies could restrict cancerous cells' ability to grow

Genetic polymorphisms may serve as prognostic markers for lung cancer

Nivolumab, ipilimumab duo effective in poor prognosis advanced melanoma patients

Researchers identify role of microglia during early stages of Alzheimer's disease

Clinical data from spinal muscular atrophy program presented at 20th International WMS Congress

Beta-catenin shows treatment target potential for TKI-resistant CML

Experimental drug shows promise in mice with multiple sclerosis

Two studies identify promising new anti-retroviral strategy to combat HIV-1

Study suggests link between human endogenous retroviral genes and ALS

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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