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Researchers identify key factors for successful donor lymphocyte infusion in AML patients

Dana-Farber Cancer Institute researchers have identified factors that determine whether donor lymphocyte infusion (DLI), a standard therapy for patients with acute myeloid leukemia (AML) who have relapsed after allogenic hematopoietic stem cell transplant, will successfully move the patient into remission.

24 Jan 2025

New light-based technique could transform heart tissue repair

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue.

24 Jan 2025

Breakthrough gene discovery offers new hope for medulloblastoma therapy

Scientists at The Hospital for Sick Children (SickKids) have identified a key gene that could lead to next-generation treatments for medulloblastoma, the most common malignant brain tumor in children.

24 Jan 2025

NUS researchers develop DNA barcoded nanoparticles for targeted cancer therapy

A team of researchers from the National University of Singapore (NUS) has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA barcodes.

24 Jan 2025

Key immune cells required for tissue repair following liver injury

Our livers contain many different types of immune cells. New research by the team of Prof. Charlotte Scott (VIB-UGent Center for Inflammation Research) and colleagues now reveals that a specific activation state of one of these cell types is required for tissue repair following injury.

24 Jan 2025

Dapagliflozin plus calorie restriction boosts remission rates in adults with type 2 diabetes and obesity

Findings indicate that dapagliflozin and calorie restriction together improve weight loss and metabolic health, increasing the likelihood of diabetes remission.

24 Jan 2025

Study offers new insight into how nature and nurture shape aggression in males

Like humans, mice will compete over territory and mates, and show increased confidence in their fighting skills the more they win.

24 Jan 2025

Uncertainty surrounds effects of puberty blockers and hormone therapy for gender dysphoria

Major uncertainties remain about the impact of puberty blockers and gender affirming hormone therapy on children and young people with gender related distress (gender dysphoria), making it impossible to determine conclusively whether they help or harm, find two pooled data analyses of the available evidence, published online in the Archives of Disease in Childhood.

23 Jan 2025

Study finds link between impairments in physical function and hospital readmission risk

Researchers from The Ohio State University Wexner Medical Center and College of Medicine's School of Health and Rehabilitation Sciences (HRS) recently published a study that found a link between impairments in physical function and hospital readmission risk among adults 50 years of age and older.

23 Jan 2025

New approach to treating ependymoma with leukemia drug

Rakesh Jain PhD, Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior author of a new study in PNAS, Targeting EPHB2/ABL1 Restores Anti-Tumor Immunity in Preclinical Models of Ependymoma.

23 Jan 2025

EU-funded Vigilant network aims to develop broad-spectrum antiviral drugs

Pandemics threaten both human health and the global economy. Vaccines are an essential part of the fight against pandemics, but they are only available months after the outbreak

23 Jan 2025

Study reveals abelacimab’s potential to improve anticoagulation safety for AFib patients

Abelacimab, a factor XI inhibitor, demonstrated a 62–69% reduction in major bleeding compared to rivaroxaban in atrial fibrillation patients at moderate-to-high stroke risk, with comparable safety and efficacy. While ischemic stroke rates were slightly higher, they were not statistically significant, warranting further phase 3 trials for confirmation.

23 Jan 2025

Metronomic chemotherapy offers hope for children with neuroblastoma

Neuroblastoma is the most common extracranial solid tumor in children, with nearly 50% of cases diagnosed at an advanced stage, often with metastatic disease.

23 Jan 2025

Singapore’s respiratory health gets a boost with $10 million research grant

The Academic Respiratory Initiative for Pulmonary Health (TARIPH) Centre, a national research platform led by Nanyang Technological University, Singapore's (NTU Singapore) Lee Kong Chian School of Medicine (LKCMedicine), will lead a multi-institutional research programme after being awarded Singapore's first national research grant for respiratory health.

23 Jan 2025

Researchers investigate a new combination therapy against cancer

A research team at the Medical University of Vienna led by Maria Sibilia has investigated a new combination therapy against cancer.

23 Jan 2025

AGA releases updated guidelines on hepatitis B reactivation in patients on immunosuppressive drugs

The American Gastroenterological Association (AGA) has unveiled an updated clinical practice guideline in Gastroenterology addressing the prevention and management of hepatitis B virus reactivation (HBVr) in patients on immunosuppressive drugs.

23 Jan 2025

New technology tracks millions of cells simultaneously during organ development

Thanks to a new technology called Moscot ("Multi-Omics Single-Cell Optimal Transport"), researchers can now observe millions of cells simultaneously as they develop into a new organ-for example, a pancreas.

23 Jan 2025

Real-world effectiveness and safety of olaparib in HRD-positive BRCA wild-type ovarian cancer

Ovarian cancer, a deadly gynecologic malignancy, has seen a significant shift in its treatment paradigm with the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors, which are now standard in the maintenance setting following first-line chemotherapy.

23 Jan 2025

New copper detection tool may lead to lung cancer treatment breakthrough

The Chang Lab at Princeton Chemistry continues in its mission to elucidate the role of metal nutrients in human biology: last year, iron; this year, copper.

22 Jan 2025

Brain signals involved in reward learning may hold key to personalized depression treatments

In a study in the Journal of Affective Disorders, Fralin Biomedical Research Institute scientists Pearl Chiu and Brooks Casas investigate how brain signals involved in reward learning might help personalize depression treatment.

22 Jan 2025

Therapy News and Research

Researchers identify key factors for successful donor lymphocyte infusion in AML patients

New light-based technique could transform heart tissue repair

Breakthrough gene discovery offers new hope for medulloblastoma therapy

NUS researchers develop DNA barcoded nanoparticles for targeted cancer therapy

Key immune cells required for tissue repair following liver injury

Dapagliflozin plus calorie restriction boosts remission rates in adults with type 2 diabetes and obesity

Study offers new insight into how nature and nurture shape aggression in males

Uncertainty surrounds effects of puberty blockers and hormone therapy for gender dysphoria

Study finds link between impairments in physical function and hospital readmission risk

New approach to treating ependymoma with leukemia drug

EU-funded Vigilant network aims to develop broad-spectrum antiviral drugs

Study reveals abelacimab’s potential to improve anticoagulation safety for AFib patients

Metronomic chemotherapy offers hope for children with neuroblastoma

Singapore’s respiratory health gets a boost with $10 million research grant

Researchers investigate a new combination therapy against cancer

AGA releases updated guidelines on hepatitis B reactivation in patients on immunosuppressive drugs

New technology tracks millions of cells simultaneously during organ development

Real-world effectiveness and safety of olaparib in HRD-positive BRCA wild-type ovarian cancer

New copper detection tool may lead to lung cancer treatment breakthrough

Brain signals involved in reward learning may hold key to personalized depression treatments

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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