Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Myeloid-derived suppressor cells may serve as biomarkers for idiopathic pulmonary fibrosis

Researchers at Helmholtz Zentrum München, a partner in the German Center for Lung Research, have discovered that the number of myeloid-derived suppressor cells (MDSC) is increased in the blood of patients with idiopathic pulmonary fibrosis (IPF).

2 Sep 2016

Study highlights possible reasons for MS misdiagnosis

A number of common conditions are mistaken for multiple sclerosis (MS), a disabling central nervous system disease, say researchers at four academic medical centers across the U.S in a study published online August 31, 2016 in the journal Neurology.

1 Sep 2016

Research findings could lead to new biomarker for early stages of tumor development

To treat or not to treat? That is the question researchers at the Department of Energy's Lawrence Berkeley National Laboratory hope to answer with a new advance that could help doctors and their cancer patients decide if a particular therapy would be worth pursuing.

31 Aug 2016

Investigational biomarker surpasses current gold standard test for identifying brain shunt infections

In a study of children with brain shunts at Children's of Alabama, a University of Alabama at Birmingham investigational biomarker outperformed the current "gold standard" test for detecting bacterial infections in the shunts.

30 Aug 2016

New NCCN Imaging AUC released for eight new cancers

The National Comprehensive Cancer Network, a Centers for Medicare & Medicaid Services-approved provider-led entity for imaging appropriate use criteria, continues to build its library of AUC and has published NCCN Imaging Appropriate Use Criteria for eight new cancer types. Launched in June 2016, NCCN Imaging AUC currently are available for 20 cancer types.

29 Aug 2016

Fluid-filled sacs that brain cells make to trap amyloid may contribute to Alzheimer's disease

Vesicles, fluid-filled sacs that brain cells make to trap amyloid, a hallmark of Alzheimer's, appear to also contribute to the disease, scientists report.

29 Aug 2016

Boehringer Ingelheim and Duke expand collaboration to create largest patient registry for idiopathic pulmonary fibrosis (IPF)

Boehringer Ingelheim Pharmaceuticals, Inc. and the Duke Clinical Research Institute (DCRI) announced today the expansion of the Idiopathic Pulmonary Fibrosis – PROspective Outcomes (IPF-PRO) Registry, a patient registry developed to uncover insights into IPF, a rare and serious lung disease. The expansion will increase the study enrollment from 300 patients at 18 study sites to 1,500 patients at approximately 45 sites, creating the largest registry of newly diagnosed IPF patients.

29 Aug 2016

Surgical repair of mitral valve may provide greater benefit in patients with no symptoms

A new study recently published in the Journal of Thoracic and Cardiovascular Surgery questions whether patients with isolated moderate to severe mitral valve regurgitation should receive treatment in earlier stages instead of waiting until symptoms appear.

25 Aug 2016

New MRI method detects low zinc levels to help identify healthy prostate tissue from cancer

A novel MRI method that detects low levels of zinc ion can help distinguish healthy prostate tissue from cancer, UT Southwestern Medical Center radiologists have determined.

23 Aug 2016

Low selenium levels linked to liver cancer risk? An interview with Dr David Hughes

Food provides us with a variety of substances we need to maintain life. These substances are essential nutrients and are classified as macronutrients (water, protein, fats, and carbohydrates) and micronutrients (vitamins and minerals).

22 Aug 2016

Study examines psychological impact of tumor gene testing in subset of NCI-MATCH patients

The ECOG-ACRIN Cancer Research Group has received federal approval to add a quality-of-life research study, COMmunication and Education in Tumor Profiling (EAQ152) or 'COMET' to the NCI-MATCH (EAY131) trial, already underway.

19 Aug 2016

New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

A new measurement standard developed by the National Institute of Standards of Technology has been used successfully by the Frederick National Laboratory for Cancer Research to check the performance of next-generation DNA-sequencing technologies for evaluating gene variations associated with an increased risk of breast cancer.

18 Aug 2016

Scientists examine how neural responses change over time in patients with Parkinson's disease

Neuroscientists peered into the brains of patients with Parkinson's disease and two similar conditions to see how their neural responses changed over time.

16 Aug 2016

Scientists develop novel method to widen usage of blood in biomarker discovery and analysis

Scientists at Karolinska Institutet in collaboration with Estonian Competence Centre on Health Technologies have developed a new gene expression analysis method to widen the usage of blood in biomarker discovery and analysis. Their paper is published in the journal Scientific Reports.

16 Aug 2016

Study shows microRNA molecule prevents cancer cells from responding to chemotherapy treatment

Annually about 2000 Danish patients with colorectal cancer are treated with chemotherapy. Today, a range of different chemotherapeutic regimens are available. However, deciding which regimen to use is not easy.

16 Aug 2016

New, non-invasive way to monitor progression of Parkinson's disease may help improve treatment

A new, non-invasive way to track the progression of Parkinson's disease could help evaluate experimental treatments to slow or stop the disease's progression.

16 Aug 2016

BCL-2 inhibitor shows promise in AML patients

Patients whose acute myelogenous leukemia (AML) had relapsed or was resistant to chemotherapy and those who were deemed unable to tolerate chemotherapy experienced responses to the selective BCL-2 inhibitor venetoclax (Venclexta), with complete remissions in some, according to phase II clinical trial data.

12 Aug 2016

Gut microbiome can influence common dietary compound linked to heart disease

In the last five years, some scientists have cautioned against eating eggs and meat because these foods generate a common dietary compound, trimethylamine N-oxide (TMAO), that research has suggested plays a role in heart disease.

11 Aug 2016

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Immune response measured in tumor biopsies during the course of early treatment predicts which melanoma patients will benefit from specific immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cancer Discovery.

11 Aug 2016

Integration of multiple types of protein biomarkers improves ability to detect breast cancer

A first-time study published in PLOS ONE shows that a combined assessment of multiple types of protein biomarkers in the blood offers an important advancement for detecting early breast cancer.

11 Aug 2016

Biomarker News and Research

Further Reading

Myeloid-derived suppressor cells may serve as biomarkers for idiopathic pulmonary fibrosis

Study highlights possible reasons for MS misdiagnosis

Research findings could lead to new biomarker for early stages of tumor development

Investigational biomarker surpasses current gold standard test for identifying brain shunt infections

New NCCN Imaging AUC released for eight new cancers

Fluid-filled sacs that brain cells make to trap amyloid may contribute to Alzheimer's disease

Boehringer Ingelheim and Duke expand collaboration to create largest patient registry for idiopathic pulmonary fibrosis (IPF)

Surgical repair of mitral valve may provide greater benefit in patients with no symptoms

New MRI method detects low zinc levels to help identify healthy prostate tissue from cancer

Low selenium levels linked to liver cancer risk? An interview with Dr David Hughes

Study examines psychological impact of tumor gene testing in subset of NCI-MATCH patients

New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

Scientists examine how neural responses change over time in patients with Parkinson's disease

Scientists develop novel method to widen usage of blood in biomarker discovery and analysis

Study shows microRNA molecule prevents cancer cells from responding to chemotherapy treatment

New, non-invasive way to monitor progression of Parkinson's disease may help improve treatment

BCL-2 inhibitor shows promise in AML patients

Gut microbiome can influence common dietary compound linked to heart disease

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Integration of multiple types of protein biomarkers improves ability to detect breast cancer

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