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Daily active commuting associated with lower levels of inflammation

A new study, conducted by the University of Eastern Finland, the Finnish Institute for Health and Welfare, and the Finnish Institute of Occupational Health, shows that engaging in active commuting for a minimum of 45 minutes a day was associated with lower levels of C-reactive protein (CRP), a key marker of inflammation.

16 Jan 2024

Chronic inflammation and poverty join forces to increase mortality risk

A new study led by a University of Florida College of Public Health and Health Professions researcher finds that people with chronic inflammation living in poverty have more than double the risk of dying from heart disease and nearly triple the risk of dying from cancer within the next 15 years.

16 Jan 2024

TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

Excessive alcohol intake is strongly associated with alcohol-associated liver disease (ALD) which accounts for 25% and 30% of deaths from cirrhosis and hepatocellular carcinoma. Impairment of Ca2+ influx and Ca2+-mediated signaling in ALD suggests that Ca2+ channels are important in ALD pathological progression.

16 Jan 2024

Poverty may combine in a synergistic manner with chronic inflammation to reduce health, life expectancy

In the US, approximately 37.9 million people, or 11.4% of the population, lived below the poverty line in 2022.

16 Jan 2024

Natural PLA2 inhibitor from marine fungus combats fatty liver disease by silencing lipotoxic pathways

This new article publication from Acta Pharmaceutica Sinica B, discusses the identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling.

16 Jan 2024

"Healthy Smiles, Healthy Hearts" initiative bridges oral health and heart health

A patient's oral health can be an indicator of overall health and well-being. Research shows that chronic gum inflammation may be associated with other chronic diseases including coronary artery disease and diabetes.

16 Jan 2024

High fat mass in adolescence could worsen insulin resistance and obesity by young adulthood

High fat mass in adolescence causes insulin resistance, which can lead to a vicious cycle of worsening insulin resistance and obesity by young adulthood, a new study shows.

16 Jan 2024

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

This new article publication from Acta Pharmaceutica Sinica B, discusses how GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.

15 Jan 2024

Ancient genomes reveal origins of multiple sclerosis risk in Europe

Researchers investigated the variables contributing to geographical heterogeneity in multiple sclerosis prevalence and the impact of genetic and environmental factors on the disease's development.

15 Jan 2024

Immune dysregulation in long COVID patients uncovered in new study

Sstudy reveals significant immune changes in long COVID patients, including altered T cell responses and systemic inflammation, using advanced 'omics' and serological assays.

14 Jan 2024

Study explores intratumoral microbiota as a novel frontier in cancer research

Researchers review the role of intratumoral microbiota in cancer development, suggesting its potential in predicting and treating various cancers.

14 Jan 2024

Hundreds of chemicals linked to breast cancer risk identified in new study

Study identifies 921 chemicals potentially linked to breast cancer risk, using a framework evaluating genotoxicity and endocrine activity.

14 Jan 2024

Study links stress to metabolic syndrome, highlights inflammation's role

New research links stress to metabolic syndrome through inflammation, suggesting stress management as a potential strategy for improving biological health outcomes.

13 Jan 2024

Increased cholesterol levels in adolescence linked to early heart damage

Heart disease is the number one killer disease in the world. Elevated cholesterol and dyslipidaemia in children and adolescents increase the risk of premature death in the mid-forties and subclinical atherosclerosis in the mid-twenties.

13 Jan 2024

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

12 Jan 2024

Defective gene triggers uncontrolled immune attack in young lupus patients

A group of researchers lead by Min Ae Lee-Kirsch from the Department of Pediatrics, Medical Faculty, TUD Dresden University of Technology (Germany), studied four patients from two families who developed symptoms of SLE in the first years of life.

12 Jan 2024

Gum bacteria fuel COPD through immune cell activation

Severe gum disease has been linked to the progression of chronic obstructive pulmonary disease, or COPD, but an understanding of how the connection plays out in the immune system remains unclear.

12 Jan 2024

AI algorithm may better support clinical care and research by identifying patients with adverse social determinants of health

A new study explores the use of large language models (LLMs) to obtain such vital data from EHRs to improve research outcomes and offer better clinical care.

12 Jan 2024