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The impact of KRAS mutations on pancreatic cancer progression and survival

A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead to less invasiveness and weaker biological activity, according to a multicenter study conducted at Weill Cornell Medicine, NewYork-Presbyterian, Memorial Sloan Kettering Cancer Center, and other institutions.

3 Oct 2024

Scientists overcome major challenge in gene therapy and drug delivery

Imagine trying to poke a hole in the yolk of a raw egg without breaking the egg white. It sounds impossible, but researchers at the University of California San Diego have developed a technology that performs a similarly delicate task in living cells. They created an array of nanopillars that can breach the nucleus of a cell - the compartment that houses our DNA - without damaging the cell's outer membrane.

3 Oct 2024

Study highlights the role of genetic factors in COVID-19 thrombosis and inflammation

Despite global vaccination efforts, COVID-19 continues to pose significant risks, leading to severe complications and fatalities. These risks are driven by disrupted coagulation, impaired fibrinolysis, which is the process of breaking blood clots, and heightened inflammatory responses.

3 Oct 2024

Plant polyphenols: The secret to living longer and healthy aging?

Plant polyphenols show promise in combating aging, supporting mitochondrial health and reducing inflammation, potentially improving quality of life for seniors.

2 Oct 2024

Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies

Researchers used stem-cell derived organoids from Crohn's disease patients to identify two molecular subtypes, paving the way for personalized treatments targeting specific disease characteristics.

2 Oct 2024

CheekAge can accurately predict the risk of mortality, study shows

We don't all age at the same rate. But while some supercentenarians may age exceptionally slowly due to winning the genetics jackpot, a plethora of behavioral and lifestyle factors are known to speed up aging, including stress, poor sleep, poor nutrition, smoking, and alcohol.

1 Oct 2024

Research heralds in a new era for genetic sequencing and testing

Research led by scientists at Queen Mary University of London is heralding in a new era for genetic sequencing and testing.

1 Oct 2024

Study reveals genetic elements driving Klebsiella pneumoniae hypervirulence

More than a decade ago, physicians around the world began reporting cases due to a new hypervirulent strain of Klebsiella pneumoniae, which could infect and severely sicken otherwise healthy people.

1 Oct 2024

Genetic study uncovers key drivers of metabolic syndrome with brain tissue links

Researchers uncovered 1,307 genetic loci linked to metabolic syndrome, revealing brain tissue enrichment and key genetic factors in its development. The study also shows polygenic risk scores predict metabolic syndrome across populations.

1 Oct 2024

Epigenetic hallmarks of cancer unveiled in new research

Cancer mortality has just surpassed cardiovascular disease for the first time ever and one in two men, and one in three women, will be diagnosed with some form of the disease in the US, according to the NIH.

1 Oct 2024

New insights improve genetic classification for hereditary colorectal cancer

The genetic confirmation of a suspected diagnosis of "hereditary colorectal cancer" is of great importance for the medical care of affected families.

1 Oct 2024

New humanized mouse models created to study COVID-19

Scientists at La Jolla Institute for Immunology (LJI) have developed six lines of humanized mice that can serve as valuable models for studying human cases of COVID-19.

1 Oct 2024

Air pollution linked to brain changes in children

Outdoor air pollution from power plants, fires and cars continues to degrade human, animal and environmental health around the globe.

1 Oct 2024

Inflammatory proteins linked to higher risk of endometrial cancer

Study identifies key inflammatory and immune response proteins linked to endometrial cancer risk through both observational and Mendelian Randomization analyses, revealing the roles of IL-6 and HSD11B1.

1 Oct 2024

Future directions and challenges in harnessing NK cells against Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) remains one of the most challenging hematological malignancies to treat, with relapse and refractory cases continuing to pose significant hurdles

1 Oct 2024

Combining apple peel and mistletoe extracts to boost muscle health and endurance

Research shows that mistletoe and apple peel extracts improve muscle health and endurance, suggesting a natural approach to combat age-related muscle decline.

1 Oct 2024

ERS Genomics and Université de Montréal sign CRISPR/Cas9 license agreement

Université de Montréal gains access to ERS Genomics' CRISPR/Cas9 patents, launching platforms for genome-wide screening and fostering research collaborations.

From ERS Genomics 1 Oct 2024

Scientists uncover role of Wnt in kidney formation

A group of essential signaling molecules known as the Wnt pathway emerged early in the evolution of multicellular life. Scientists have been studying Wnt actions for four decades to comprehend its complex roles in development and disease.

1 Oct 2024

Vitamin B12 boosts testosterone levels in men with infertility

Research finds that higher serum vitamin B12 levels are associated with improved testosterone concentrations in men with infertility, but no impact on other reproductive hormones.

30 Sep 2024

NIH grant supports research on cognitive decline in individuals with Lewy body diseases

Penn Medicine researchers will advance their understanding of the underlying causes of cognitive decline in individuals with Lewy body diseases, like Parkinson's, and identify biomarkers that predict which individuals are more likely to develop dementia with a $18 million grant from the National Institutes of Health/National Institute on Aging.

30 Sep 2024