Enzyme News and Research

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Increased severity of COVID-19 in pregnancy

A new preprint on the medRxiv* server provides more evidence that COVID-19 likely causes a more serious phenotype to arise in pregnant women.

23 Jun 2021

Heidelberg researchers replicate rare genetic defect in fish model

A rare genetic defect that affects the so-called ALG2 gene can cause serious metabolic diseases in humans. It does so through the defective formation of proteins and sugar molecules.

23 Jun 2021

SARS-CoV-2 infection and transmission in the North American deer mouse

A recent study conducted in Canada reports that the North American deer mouse can be infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans.

23 Jun 2021

Repeated vaccination could control infection with SARS-CoV-2 variants among infection-naïve individuals

Researchers have suggested that repeated vaccination against SARS-CoV-2 may enable previously uninfected individuals to cope with viral variants.

23 Jun 2021

Indian SARS-CoV-2 variant has unique infection and immune escape strategy say researchers

Researchers have conducted a study suggesting that the B.1.617 lineage of SARS-CoV-2 that emerged in India has evolved a unique strategy.

23 Jun 2021

Researchers review the origins of SARS-CoV-2 and present treatment methods

A million more questions arise for every answer we have against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Where did it come from? And will it ever go away? A recent article published in Frontiers in Cellular and Infection Microbiology reviews what scientists currently know about the origin, SARS-CoV-2 structure, and potential treatments against this new virus.

23 Jun 2021

Modulating the rap1 mechanism can help control blood sugar levels

Managing type 2 diabetes typically involves losing weight, exercise and medication, but new research by Dr. Makoto Fukuda and colleagues at Baylor College of Medicine and other institutions suggests that there may be other ways to control the condition through the brain.

23 Jun 2021

Enzyme in fat tissue helps control the production of new bone and fat cells, study shows

An enzyme found in fat tissue in the center of our bones helps control the production of new bone and fat cells, shows a study in mice published today in eLife.

22 Jun 2021

Do the Moderna and Pfizer COVID-19 vaccines elicit different antibody responses?

A recent study led by scientists from the United States has compared the anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody response among clinicians who have been immunized with Pfizer/BioNTech or Moderna coronavirus disease 2019 (COVID-19) vaccine.

22 Jun 2021

Researchers screen Chinese herbal medicines and plant compounds for anti-SARS-CoV-2 activity

A review published in Phytotherapy Research discussed the natural anti-SARS-CoV-2 products identified based on in silico prediction. The review’s authors also illustrate the impact of many phytochemicals either alone or in combination with traditional treatments and their potential molecular mechanisms involved in SARS-CoV-2 prevention and treatment.

22 Jun 2021

Does SARS-CoV-2 alter the expression of molecules involved in the homeostasis of blood pressure?

A recent study finds that COVID-19 alters the expression of several molecules involved in the homeostasis of blood pressure.

22 Jun 2021

Study shows a robust immune response to COVID-19 vaccine in breastfeeding health workers

A recent study by researchers from Poland, published in the journal Vaccines, shows how levels of IgA and IgG antibodies specific to the spike glycoprotein of SARS-CoV-2 increase in both breast milk and serum samples of mothers following vaccination against COVID-19 – with important implications for further vaccine planning endeavors.

21 Jun 2021

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

An interesting new study describes the activities of a family of viral enzymes called two-histidine-phosphoesterases (2H-PEs), found in coronaviruses (CoVs) and rotaviruses, as well as a mammalian A-kinase anchoring protein enzyme, AKAP7, that shares the same function. Together called 2’,5’-PEs, these enzymes all break down 2’,5’-oligoadenylate compounds that activate the antiviral enzyme ribonuclease L (RNase L).

21 Jun 2021

Can a prior rhinovirus infection protect against COVID-19?

Researchers at the Yale School of Medicine found that rhinovirus accelerates interferon-stimulated genes.

21 Jun 2021

Zinc inhibits SARS-CoV-2’s main protease in vitro

Zinc has antiviral properties. However, the detailed kinetics and the mechanism of zinc in the inhibition of viruses, particularly SARS-CoV-2 – the causative virus of COVID-19 – is unclear. To probe the role of zinc as an anti-SARS-CoV-2 agent at the structural and molecular level, researchers in India studied the binding kinetics and the inhibition mechanism of zinc with SARS-CoV-2’s viral proteins.

21 Jun 2021

Study shows that COVID-19 was present in five U.S. states in December 2019, even before the first reported case in China

In a recent study, a group of researchers aimed to identify exactly how early SARS-CoV-2 was circulating throughout the United States.

21 Jun 2021

New test is cheaper, easier, and can reliably diagnose SARS-CoV-2 infection

New lateral flow test Vigilant is cheaper, easier to use and as reliable as the current gold standard PCR test for diagnosing SARS-CoV-2 infection.

21 Jun 2021

Gasdermin D plays a key role in the maturation and release of IL-1α

Interluekin-1α (IL-1α) is an important part of the immune response, but until now it has been unclear how this molecule is processed from its precursor, pro-IL-1α, and exits the cell during inflammasome activation.

21 Jun 2021

Yeast cell machinery seamlessly 'reads' the unnatural ingredients in the genetic recipe

If the genome is the recipe of life, base pairs are the individual ingredients listed. These chemical structures form DNA, and every living organism on Earth has just four. The specific arrangements of these four base pairs -- A, T, C, G -- make us who and what we are.

18 Jun 2021

Could a fungus-derived compound reduce hyperinflammation in severe COVID-19?

New research from scientists at the University of Pennsylvania, USA, demonstrates that cyclosporine A (CSA), a calcineurin inhibitor that modulates cytokine production, may have potential antiviral properties against coronaviruses.

18 Jun 2021

Enzyme News and Research

Increased severity of COVID-19 in pregnancy

Heidelberg researchers replicate rare genetic defect in fish model

SARS-CoV-2 infection and transmission in the North American deer mouse

Repeated vaccination could control infection with SARS-CoV-2 variants among infection-naïve individuals

Indian SARS-CoV-2 variant has unique infection and immune escape strategy say researchers

Researchers review the origins of SARS-CoV-2 and present treatment methods

Modulating the rap1 mechanism can help control blood sugar levels

Enzyme in fat tissue helps control the production of new bone and fat cells, study shows

Do the Moderna and Pfizer COVID-19 vaccines elicit different antibody responses?

Researchers screen Chinese herbal medicines and plant compounds for anti-SARS-CoV-2 activity

Does SARS-CoV-2 alter the expression of molecules involved in the homeostasis of blood pressure?

Study shows a robust immune response to COVID-19 vaccine in breastfeeding health workers

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

Can a prior rhinovirus infection protect against COVID-19?

Zinc inhibits SARS-CoV-2’s main protease in vitro

Study shows that COVID-19 was present in five U.S. states in December 2019, even before the first reported case in China

New test is cheaper, easier, and can reliably diagnose SARS-CoV-2 infection

Gasdermin D plays a key role in the maturation and release of IL-1α

Yeast cell machinery seamlessly 'reads' the unnatural ingredients in the genetic recipe

Could a fungus-derived compound reduce hyperinflammation in severe COVID-19?

Understanding the DNA Damage Response in Innate Immunity eBook

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