Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Scientists discover link between mutations in INPP5E gene and ciliopathies

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have discovered a connection between mutations in the INPP5E gene and ciliopathies. Their findings, which may lead to new therapies for these diseases, will appear in the online edition of Nature Genetics on August 9.

9 Aug 2009

Research details role of galectin-3 in heart failure

BG Medicine today announced the publication of a peer-reviewed article on the role of galectin-3 in heart failure development and progression.

6 Aug 2009

Aradigm receives orphan drug designation for inhaled liposomal ciprofloxacin to treat cystic fibrosis in Europe

Aradigm Corporation (OTCBB:ARDM) has announced that the European Medicines Agency (EMEA) granted Orphan Drug Designation to the Company’s inhaled liposomal ciprofloxacin drug product candidate for the treatment of lung infections associated with cystic fibrosis (“CF”).

6 Aug 2009

Discovery of potential treatment for spinal muscular atrophy

Spinal Muscular Atrophy is the second-leading cause of infant mortality in the world. Ravindra Singh, associate professor in biomedical sciences at Iowa State University's College of Veterinary Medicine, would like to see Spinal Muscular Atrophy lose its high ranking and even slide off the list altogether.

28 Jul 2009

Miglustat shows promise for cystic fibrosis

Miglustat is a drug currently under phase 2 clinical trials on patients suffering from cystic fibrosis (1). Its potential for treating the disease was discovered in 2006 thanks to the work of Frédéric Becq's team at the Institute of Cell Physiology and Biology (CNRS/Université de Poitiers), funded by the associations Vaincre la Mucoviscidose, MucoVie66, La Pierre Le Bigaut and ABCF2.

21 Jul 2009

Cystic fibrosis medicines that help to break down mucus in the lungs may carry an unexpected long-term benefit

Cystic fibrosis medicines that help to break down mucus in the lungs may carry an unexpected long-term benefit, a study suggests.

16 Jul 2009

Xerostomia linked to use of multiple medications

Approximately ninety-one percent of dentists say patients complaining about dry mouth are taking multiple medications, according to a nationwide member survey conducted by the Academy of General Dentistry (AGD).

9 Jul 2009

Researchers profile genes in acutely ill idiopathic pulmonary fibrosis patients

The first findings from a one-of-a-kind, patient-driven effort to provide lung tissue for research might help doctors predict when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to interventions that could sustain them until life-saving transplants can be performed.

7 Jul 2009

New test detects genetic and chromosomal abnormalities in embryos - ready for clinical trials

One-step screening for both genetic and chromosomal abnormalities has come a stage closer as scientists announced that an embryo test they have been developing has successfully screened cells taken from spare embryos that were known to have cystic fibrosis.

30 Jun 2009

Women with cystic fibrosis can have safe and successful fertility treatment

Women with cystic fibrosis can have fertility treatment to help them have babies without any long-term adverse effects on either themselves or their children, according to new research presented at the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam today (Tuesday).

30 Jun 2009

Research shows it is possible to freeze embryos and reduce multiple pregnancies in PGD cycles without adversely affecting pregnancy rates

Transferring just one embryo at a time to a woman's womb after embryos have undergone preimplantation genetic diagnosis (PGD) and freezing at the blastocyst stage has become a real option after researchers achieved pregnancy rates that were as good as those for blastocysts that had not had a cell removed for PGD before freezing. Their results mean that it will be possible to reduce the number of multiple pregnancies after PGD and the consequent complications associated with these pregnancies.

30 Jun 2009

Discovery of novel mechanism that could be targeted to prevent cancer spread

Researchers have discovered a key to the function of a specific protein that helps control the levels of other critical proteins within cells, including a protein that suppresses the spread of cancer. The new information about the mechanism of action of the protein, called gp78, may enable researchers to explore new types of therapies to prevent the spread of cancer. The study, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, was published in the June 26, 2009, issue of Molecular Cell.

28 Jun 2009

Trial of new ‘combo’ treatment for hepatitis C

In a multi-center trial led by a Saint Louis University researcher, investigators found that a new combination therapy of daily consensus interferon and ribavirin helps some hepatitis C patients who have not responded to previous treatment.

17 Jun 2009

Study redefines alcohol and smoking’s role in pancreatitis

Although alcohol consumption is known to be associated with chronic pancreatitis, new evidence indicates that a threshold of five or more drinks per day is required to significantly raise risk; however, most patients with chronic pancreatitis do not drink this amount, according to a report in the June 8 issue of Archives of Internal Medicine. In addition, smoking is an independent, dose-dependent risk factor.

9 Jun 2009

Discovery of protein that helps determine progression of idiopathic pulmonary fibrosis

Researchers say the protein - Serum surfactant protein A - is superior to other IPF predictors and could lead to better decisions about treatment and timing of lung transplantation.

4 Jun 2009

Blood pressure drug reverses liver damage

British scientists have discovered that blood-pressure drugs can reverse the effects of early-stage liver failure in some patients.

1 Jun 2009

Blood-pressure medicine shown to reverse the effects of early-stage liver failure

Newcastle University researchers analysed a small clinical trial of losartan, a drug normally prescribed for hypertension, on 14 patients in Spain, who had Hepatitis C.

31 May 2009

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

University at Buffalo researchers have demonstrated for the first time that injecting adult bone marrow stem cells into skeletal muscle can repair cardiac tissue, reversing heart failure.

28 May 2009

Aerosol delivery of antibiotics via nanoparticles

Aerosol delivery of antibiotics via nanoparticles may provide a means to improve drug delivery and increase patient compliance, thus reducing the severity of individual illnesses, the spread of epidemics, and possibly even retarding antibiotic resistance.

19 May 2009

Sodium channel-blocking agent shows promise as a potential treatment for cystic fibrosis

Cystic fibrosis patients may benefit from a new therapy that increases airway hydration, preventing the buildup of mucous, which is a key factor in the disease, according to researchers at Parion Sciences in Durham, N.C.

17 May 2009

Fibrosis News and Research

Further Reading

Scientists discover link between mutations in INPP5E gene and ciliopathies

Research details role of galectin-3 in heart failure

Aradigm receives orphan drug designation for inhaled liposomal ciprofloxacin to treat cystic fibrosis in Europe

Discovery of potential treatment for spinal muscular atrophy

Miglustat shows promise for cystic fibrosis

Cystic fibrosis medicines that help to break down mucus in the lungs may carry an unexpected long-term benefit

Xerostomia linked to use of multiple medications

Researchers profile genes in acutely ill idiopathic pulmonary fibrosis patients

New test detects genetic and chromosomal abnormalities in embryos - ready for clinical trials

Women with cystic fibrosis can have safe and successful fertility treatment

Research shows it is possible to freeze embryos and reduce multiple pregnancies in PGD cycles without adversely affecting pregnancy rates

Discovery of novel mechanism that could be targeted to prevent cancer spread

Trial of new ‘combo’ treatment for hepatitis C

Study redefines alcohol and smoking’s role in pancreatitis

Discovery of protein that helps determine progression of idiopathic pulmonary fibrosis

Blood pressure drug reverses liver damage

Blood-pressure medicine shown to reverse the effects of early-stage liver failure

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

Aerosol delivery of antibiotics via nanoparticles

Sodium channel-blocking agent shows promise as a potential treatment for cystic fibrosis

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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