Preclinical News and Research

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Scientists discover how potential new drug targets spinal muscular atrophy

Spinal muscular atrophy (SMA) is a genetic disease that can leave infants with weak muscles and trouble breathing. Many with the disease die before age two. To help these patients, doctors need therapies that target the genetic mutation and stop its progression.

8 May 2018

Alnylam achieves delivery of novel siRNAs conjugates to the central nervous system

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that the Company has achieved delivery of novel small interfering RNA conjugates to the central nervous system and is planning to advance a pipeline of investigational RNAi therapeutics into clinical development.

8 May 2018

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Functional loss of ARID1a, a frequently mutated tumor suppressor gene, causes deficiencies in normal DNA repair and may sensitize tumors to immune checkpoint blockade therapies, according to researchers from The University of Texas MD Anderson Cancer Center.

8 May 2018

Cognitive remediation services can feasibly be implemented in large systems of care

Cognitive remediation, an evidence-based, recovery-oriented behavioral intervention for patients with mental illness, can feasibly be implemented in large systems of care, according to researchers at the New York State Psychiatric Institute and Columbia University Irving Medical Center.

4 May 2018

Noise annoyance associated with increased risk of atrial fibrillation

With an increasing level of noise, the incidence of atrial fibrillation also increases dramatically. Scientists from the Department of Cardiology at the Mainz University Medical Center were able to prove this with data from the Gutenberg Health Study.

3 May 2018

Researchers develop novel theranostic procedure for treating ductal pancreatic adenocarcinoma

German researchers have developed a novel diagnostic and therapeutic (theranostic) procedure for patients with ductal pancreatic adenocarcinoma, a deadly cancer with an extremely poor prognosis (five-year survival rate of less than 5 percent) and limited treatment options. The study is featured in the May issue of The Journal of Nuclear Medicine.

2 May 2018

Scientists discover new target in the treatment of pulmonary hypertension

In a recent study, scientists found that eliminating the FoxM1 gene could improve outcomes for patients with pulmonary hypertension.

1 May 2018

Novel magnetic nanoparticles move from lab to first breast cancer clinical trials

Sandia National Laboratories materials chemist Dale Huber has been working on the challenge of making iron-based nanoparticles the exact same size for 15 years.

30 Apr 2018

Accelerator Life Science Partners launches new company to develop novel therapy for seizure disorders

Accelerator Life Science Partners (Accelerator), a leading life science investment and management firm, today announced that it has launched Proniras Corporation, a company developing tezampanel for the treatment of a variety of seizure disorders.

27 Apr 2018

Scientists discover potential therapeutic target for devastating premature aging disease

Scientists from the University of Cambridge have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS), which is characterized by premature aging.

27 Apr 2018

Italy's prestigious Veneto Institute of Oncology acquires MILabs' latest VECTor5CT system

The Istituto Oncologico Veneto has acquired MILabs’ latest generation VECTor5CT as a key imaging tool to support its translational oncology mission, entrusted by the Italian Ministry of Health and the Organization of the European Cancer Institutes.

25 Apr 2018

New combination therapy could improve survival in children with high-risk neuroblastoma

Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages--a type of immune cell--can negatively affect the response to chemotherapy against neuroblastoma.

25 Apr 2018

New compound could offer pain-relieving properties without risk of addiction

Researchers at the University of Michigan have engineered a new compound that animal tests suggest could offer the pain-relieving properties of opioids such as morphine and oxycodone without the risk of addiction.

24 Apr 2018

NF-κB1 gene known to drive cancer development is critical for preventing stomach cancers

Melbourne researchers have made the surprise discovery that the 'odd one out' in a family of proteins known to drive cancer development is instead critical for preventing stomach cancers.

24 Apr 2018

Clinical trial to examine stem cell therapy for treatment, prevention of complications after traumatic injury

The University of Texas Health Science Center at Houston has received funding through a public/private partnership for the first-ever clinical trial investigating a stem cell therapy for early treatment and prevention of complications after severe traumatic injury.

23 Apr 2018

Newly developed drug compound may help treat Charcot-Marie-Tooth disease

Scientists have developed a new drug compound that shows promise as a future treatment for Charcot-Marie-Tooth disease, an inherited, often painful neurodegenerative condition that affects nerves in the hands, arms, feet and legs.

20 Apr 2018

Experimental compound reduces destructive inflammation to improve stroke outcome

An experimental compound appears to improve stroke outcome by reducing the destructive inflammation that can continue months after a stroke, scientists report.

20 Apr 2018

AYOXXA to develop multiplex immunoassay to support treatment of sepsis patients

AYOXXA Biosystems GmbH, an international biotechnology company, will develop a multiplex assay to support the treatment of sepsis patients as part of the project "SepsisData.Net.NRW - Digitized Pattern Recognition for Personalized Treatment of Sepsis Patients". The development will be based on the Company’s innovative bead-based protein analysis platform LUNARIS™.

20 Apr 2018

Concussion recovery and symptom severity found to vary between men and women

A new study comparing male and female athletes examined whether there are clear sex-related differences in post-concussion symptom severity and length of recovery. In addition to a finding of significant differences between the male and female college varsity athletes, differences among the women depending on hormonal contraceptive use were reported in the study published in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

20 Apr 2018

NovaDigm Therapeutics initiates NDV-3A Phase 2a study for reduction of S. aureus in military trainees

NovaDigm Therapeutics, a company developing innovative immuno-therapeutics and preventative vaccines for fungal and bacterial infections, today announced the initiation of a Phase 2a study evaluating NDV-3A for the reduction of Staphylococcus aureus (S. aureus) colonization in a high-risk population of military trainees.

19 Apr 2018

Preclinical News and Research

Scientists discover how potential new drug targets spinal muscular atrophy

Alnylam achieves delivery of novel siRNAs conjugates to the central nervous system

Preclinical study suggests ARID1a mutations may help predict immunotherapy success

Cognitive remediation services can feasibly be implemented in large systems of care

Noise annoyance associated with increased risk of atrial fibrillation

Researchers develop novel theranostic procedure for treating ductal pancreatic adenocarcinoma

Scientists discover new target in the treatment of pulmonary hypertension

Novel magnetic nanoparticles move from lab to first breast cancer clinical trials

Accelerator Life Science Partners launches new company to develop novel therapy for seizure disorders

Scientists discover potential therapeutic target for devastating premature aging disease

Italy's prestigious Veneto Institute of Oncology acquires MILabs' latest VECTor5CT system

New combination therapy could improve survival in children with high-risk neuroblastoma

New compound could offer pain-relieving properties without risk of addiction

NF-κB1 gene known to drive cancer development is critical for preventing stomach cancers

Clinical trial to examine stem cell therapy for treatment, prevention of complications after traumatic injury

Newly developed drug compound may help treat Charcot-Marie-Tooth disease

Experimental compound reduces destructive inflammation to improve stroke outcome

AYOXXA to develop multiplex immunoassay to support treatment of sepsis patients

Concussion recovery and symptom severity found to vary between men and women

NovaDigm Therapeutics initiates NDV-3A Phase 2a study for reduction of S. aureus in military trainees

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