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Macrodomains represent a unique target for pathogens with pandemic potential

In a new study published in the journal Pathogens, researchers have summarized the role of the macrodomain in viral replication and virulence and further reviewed the development of macrodomain inhibitors as antiviral agents.

18 Jan 2022

Machine learning model identifies new risk genes for motor neurone disease

Scientists have developed a new machine learning model for the discovery of genetic risk factors for diseases such as Motor Neurone Disease (MND).

18 Jan 2022

MD Anderson and Eisbach Bio collaborate to develop precision oncology drugs

The University of Texas MD Anderson Cancer Center and Eisbach Bio GmbH today announced a strategic research collaboration to jointly discover and develop precision oncology drugs that target synthetic lethal engines key to tumor genome evolution.

18 Jan 2022

New pathways responsible for hepatocellular carcinoma identified

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. It is one of leading causes of cancer-related deaths globally, with more than 700,000 new cases and 600,000 estimated HCC deaths each year.

18 Jan 2022

Wastewater-based epidemiology to predict emerging new SARS-CoV-2 variants

In a new study, researchers established a strong approach for deducing public health-relevant epidemiological metrics like relative variant abundance and variant-specific reproduction numbers from wastewater (WW)-derived deep sequenced SARS-CoV-2 genomes.

18 Jan 2022

Exploring the viral dynamics of SARS-CoV-2 Omicron variant

In a new study, researchers posted findings in which they investigated the viral dynamics of the SARS-CoV-2 Omicron variant.

18 Jan 2022

Earth BioGenome Project moves from pilot projects to full-scale sequencing

A global effort to map the genomes of all plants, animals, fungi and other microbial life on Earth, is entering a new phase as it moves from pilot projects to full-scale production sequencing.

18 Jan 2022

Gaseous ozone is effective for SARS-CoV-2 disinfection

In their recent study published in the Journal of Hazardous Materials, researchers from the United Kingdom have found that ozone as a disinfectant is effective for the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in liquid cell culture media as well as adhered on surfaces.

18 Jan 2022

South African study confirms SARS-CoV-2 Omicron less severe than Delta even for unvaccinated

Researchers compare the outcomes of the fourth and previous waves of the COVID-19 pandemic in South Africa.

17 Jan 2022

Exploring the systemic infection of SARS-CoV-2 in a wild leopard in India

A new study focused on the pathomorphological and virological characterization of SARS-CoV-2 in naturally infected, wild Indian Leopard.

17 Jan 2022

Quantification of SARS-CoV-2 variants in wastewater samples

In a new study, a team of researchers introduced a novel method to estimate the proportion of different SARS-CoV-2 strains in wastewater samples.

17 Jan 2022

Researchers construct models to predict SARS-CoV-2 mutable and constrained positions

In a study published in PNAS, researchers have attempted to create a model that can successfully predict which positions are likely to mutate in the future.

17 Jan 2022

Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

A new paper discusses the appearance of quasi-species in a single host with prolonged infection, with different rates of infectivity and sensitivity to neutralization by antibodies elicited by the Pfizer vaccine or those present in convalescent plasma.

17 Jan 2022

Study reveals aerosol transmission of SARS-CoV-2 via floor drains

A new study investigated COVID-19 cases in an apartment complex in South Korea and explored the possibility of aerosol transmission without direct contact between infected individuals with the help of molecular phylogenetic analysis and epidemiological surveillance.

17 Jan 2022