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Using NMR to study protein motion: an interview with Fabien Ferrage, École Normale Supérieure, Paris

Can you give us a brief overview of the work you presented at ENC 2014 (Experimental Nuclear Magnetic Resonance Conference)?

From Bruker BioSpin Division 19 Aug 2014

Finding suggests that aspirin could play role in reducing breast cancer mortality

Researchers have discovered that women who had been prescribed aspirin regularly before being diagnosed with breast cancer are less likely to have cancer that spread to the lymph-nodes than women who were not on prescription aspirin. These women are also less likely to die from their breast cancer.

15 Aug 2014

Researchers find crucial signaling pathway that helps HSCs to generate

Hematopoietic stem cells (HSCs) give rise to all other blood cell types, but their development and how their fate is determined has long remained a mystery.

14 Aug 2014

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

How much is currently known about what happens in the developing brain that puts people at risk of schizophrenia?

11 Aug 2014

In vivo dopaminergic imaging strongly correlates with brain pathology

Striatal dopamine transporter binding, assessed using single-photon emission computed tomography, is strongly correlated with substantia nigra cell counts assessed at postmortem, say the authors of a study.

11 Aug 2014

Antimalarial agent chloroquine normalizes abnormal tumor blood vessels

A recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. This blood vessel normalization results in an increased barrier function on the one hand -- thereby blocking cancer cell dissemination and metastasis -- and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

11 Aug 2014

Inovio Pharmaceuticals reports increased revenue in second quarter 2014

Inovio Pharmaceuticals, Inc. today reported financial results for the quarter ended June 30, 2014. Total revenue was $3.8 million and $6.2 million for the three and six months ended June 30, 2014, compared to $786,000 and $2.2 million for the same periods in 2013.

11 Aug 2014

Hand-held photoacoustic microscopy may change the way doctors treat, diagnose melanoma

A new hand-held device that uses lasers and sound waves may change the way doctors treat and diagnose melanoma, according to a team of researchers from Washington University in St. Louis.

7 Aug 2014

Altering the circadian rhythm: an interview with Dr. Doug Kojetin, The Scripps Research Institute

The circadian rhythm is affected by many different stimuli—such as sleep and light, which are the most broadly appreciated ways—but also eating— all of which can modulate, or change, important processes in our bodies such as temperature, production of hormones or other signalling small molecules, cellular regeneration, and others.

6 Aug 2014

7.0T NMR spectroscopy detects lesions in hippocampal neurons of Alzheimer's disease

Magnetic resonance spectroscopy can quantitatively analyze in vivo abnormalities of biochemical metabolism within brain tissue in a noninvasive and non-radioactive manner.

6 Aug 2014

Study reveals intricate mechanisms involved in enzyme that governs DNA duplication

In a study published today in Genes & Development, Dr Christian Speck from the MRC Clinical Sciences Centre's DNA Replication group, in collaboration with Brookhaven National Laboratory (BNL), New York, reveal the intricate mechanisms involved in the enzyme that governs DNA duplication during cell division.

4 Aug 2014

Identification of new molecular mechanism indicates new ways to block uncontrolled cell division

1 Aug 2014

Researchers identify RNA that modulates action of important gene in process of programmed cell death

Researchers from the University of S-o Paulo (USP) have identified an RNA known as INXS that, although containing no instructions for the production of a protein, modulates the action of an important gene in the process of apoptosis, or programmed cell death.

31 Jul 2014

Nicotine, cotinine can potentially inhibit DNA damage caused by NNK in tobacco smoke

A new in vitro study has revealed that nicotine and cotinine, a metabolite of nicotine, can potentially inhibit DNA damage caused by a certain carcinogen in smoke.

28 Jul 2014

Scientists discover new pathway to manipulate, maintain human ESCs in a "na-ve"

For years, researchers and patients have hoped that embryonic stem cells (ESCs)-capable of forming nearly any cell type in the body-could provide insight into numerous diseases perhaps even be used to treat them. Yet progress has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are "primed" and slightly less plastic than the mouse cells.

26 Jul 2014

Epigenetic switch can cause cancer, shows study

Cancer has long been thought to be primarily a genetic disease, but in recent decades scientists have come to believe that epigenetic changes - which don't change the DNA sequence but how it is 'read' - also play a role in cancer.

26 Jul 2014

Kinex receives FDA approval to begin Phase I study of KX2-391 Ointment for actinic keratosis

Kinex Pharmaceuticals announced the receipt of an allowance by the US FDA for the Company's KX2-391 Ointment for the commencement of a Phase I clinical study in actinic keratosis. This is the Company's third IND to be allowed by the US FDA in the past 12 months.

25 Jul 2014

FDA approves Targiniq ER to treat severe pain

Today, the U.S. Food and Drug Administration approved Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended-release tablets), an extended-release/long-acting (ER/LA) opioid analgesic to treat pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.

24 Jul 2014

Co-targeting strategies suggested for EGFR-TKI resistance in NSCLC

Researchers have identified additional resistance mechanisms that could be targeted to improve the efficacy of irreversible epidermal growth factor receptor-tyrosine kinase inhibitors in patients with non-small-cell lung cancer harbouring both EGFR and T790M mutations.

23 Jul 2014

Marker identified for population of renal cancer cells with stem-cell-like features

Researchers have identified a population of clear cell renal cell carcinoma cells positive for the CTR2 marker that possess some stem-cell-like features and are able to induce an angiogenic response in vivo.

22 Jul 2014

in vivo News and Research

Using NMR to study protein motion: an interview with Fabien Ferrage, École Normale Supérieure, Paris

Finding suggests that aspirin could play role in reducing breast cancer mortality

Researchers find crucial signaling pathway that helps HSCs to generate

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

In vivo dopaminergic imaging strongly correlates with brain pathology

Antimalarial agent chloroquine normalizes abnormal tumor blood vessels

Inovio Pharmaceuticals reports increased revenue in second quarter 2014

Hand-held photoacoustic microscopy may change the way doctors treat, diagnose melanoma

Altering the circadian rhythm: an interview with Dr. Doug Kojetin, The Scripps Research Institute

7.0T NMR spectroscopy detects lesions in hippocampal neurons of Alzheimer's disease

Study reveals intricate mechanisms involved in enzyme that governs DNA duplication

Identification of new molecular mechanism indicates new ways to block uncontrolled cell division

Researchers identify RNA that modulates action of important gene in process of programmed cell death

Nicotine, cotinine can potentially inhibit DNA damage caused by NNK in tobacco smoke

Scientists discover new pathway to manipulate, maintain human ESCs in a "na-ve"

Epigenetic switch can cause cancer, shows study

Kinex receives FDA approval to begin Phase I study of KX2-391 Ointment for actinic keratosis

FDA approves Targiniq ER to treat severe pain

Co-targeting strategies suggested for EGFR-TKI resistance in NSCLC

Marker identified for population of renal cancer cells with stem-cell-like features

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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