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Study sheds light on how dengue virus adapts, causes outbreaks as it travels

A researcher from The University of Texas Medical Branch at Galveston is an integral member of a collaborative group that is the first to explain the mechanisms that the Dengue virus has developed to optimize its ability to cause outbreaks as it travels across the globe to new places and revisits old ones.

7 Jul 2015

City of Hope researchers to use patients' own modified T cells to treat advanced brain tumors

Already pioneers in the use of immunotherapy, City of Hope researchers are now testing the bold approach to cancer treatment against one of medicine's biggest challenges: brain cancer. This month, they will launch a clinical trial using patients' own modified T cells to fight advanced brain tumors.

7 Jul 2015

LSD1 enzyme turns off genes needed to maintain cancer stem cell properties in glioblastoma

Cancer's ability to grow unchecked is often attributed to cancer stem cells, a small fraction of cancer cells that have the capacity to grow and multiply indefinitely. How cancer stem cells retain this property while the bulk of a tumor's cells do not remains largely unknown. Using human tumor samples and mouse models, researchers at University of California, San Diego School of Medicine and Moores Cancer Center discovered that cancer stem cell properties are determined by epigenetic changes -- chemical modifications cells use to control which genes are turned on or off.

7 Jul 2015

Dental pulp stem cell transplants can contribute to peripheral nerve regeneration

Peripheral nerve injuries often are caused by trauma or surgical complications and can result in considerable disabilities. Regeneration of peripheral nerves can be accomplished effectively using autologous (self-donated) nerve grafts, but that procedure may sacrifice a functional nerve and cause loss of sensation in another part of the patient's body.

7 Jul 2015

Findings reveal new pathway to develop effective treatments and therapies for asthma, allergy

Investigators have discovered the precise molecular steps that enable immune cells implicated in certain forms of asthma and allergy to develop and survive in the body. The findings from Weill Cornell Medical College reveal a new pathway that scientists could use to develop more effective treatments and therapies for the chronic lung disorder.

7 Jul 2015

Researchers identify link between autoimmune diseases, medications and Long QT syndrome

Mohamed Boutjdir, PhD, professor of medicine, cell biology, and physiology and pharmacology at SUNY Downstate Medical Center, has led a study with international collaborators identifying the mechanism by which patients with various autoimmune and connective tissue disorders may be at risk for life-threatening cardiac events if they take certain anti-histamine or anti-depressant medications.

7 Jul 2015

AOSSM to present awards and grants to encourage cutting-edge research in orthopaedic sports medicine

In order to recognize and encourage cutting-edge research in key areas of orthopaedic sports medicine, the American Orthopaedic Society for Sports Medicine will present ten research awards and seven grants during its Annual Meeting, July 9-12 in Orlando, FL.

7 Jul 2015

New findings can help scientists generate tailor-made proteins optimized for use in optogenetics

Optogenetics techniques, which allow scientists to map and control nerve cells using light stimulation, are being used to study neural circuits in the brain with unprecedented precision. This revolutionary technology relies on light-sensitive proteins such as channelrhodopsins, and researchers at UC Santa Cruz have now determined the molecular mechanism involved in the light-induced activation of one of these proteins.

7 Jul 2015

Study uncovers complicated role of simple protein in spread of osteosarcoma

The investigation of a simple protein has uncovered its uniquely complicated role in the spread of the childhood cancer, osteosarcoma. It turns out the protein, called ezrin, acts like an air traffic controller, coordinating multiple functions within a cancer cell and allowing it to endure stress conditions encountered during metastasis.

7 Jul 2015

Study could provide paradigm shift in treatment of age-related disease, cancer

Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies.

7 Jul 2015

New therapeutic alternative found for children suffering from Ewing's sarcoma

A research consortium made up of the Virgen del Rocio hospital in Seville, Sant Joan de Deu and the Bellvitge Biomedical Research Institute in Barcelona, has found a new therapeutic alternative for children who suffer from a malignant pediatric tumor bone and soft tissue called Ewing's sarcoma.

7 Jul 2015

Blood-borne molecule promotes age-related cognitive decline

A blood-borne molecule that increases in abundance as we age blocks regeneration of brain cells and promotes cognitive decline, suggests a new study by researchers at UC San Francisco and Stanford School of Medicine.

7 Jul 2015

New research suggests that Bcl-Rambo protein can protect against heart failure

A protein dubbed 'Bcl-Rambo' can protect against heart failure, suggests new research from King's College London and funded by the British Heart Foundation.

7 Jul 2015

University of Adelaide research may lead to new treatments for transplant patients

Researchers at the University of Adelaide have discovered a new method for culturing stem cells which sees the highly therapeutic cells grow faster and stronger.

7 Jul 2015

Transitioning Infrared Imaging into Clinical Use

The CLIRSPEC network is a UK Engineering and Physical Sciences Research Council (EPSRC – EP/L012952/1) funded network in clinical infrared and Raman spectroscopy. Infrared and Raman spectroscopy can identify the hallmarks of disease and distinguish between diseased and non-diseased samples based upon inherent chemistry.

From Daylight Solutions Inc 7 Jul 2015

Sialic acid attached to brain cells may affect brain structure, cause neurological problems

New research from The Johns Hopkins University suggests that a molecule commonly found “decorating” brain cells in higher animals, including humans, may affect brain structure.

7 Jul 2015

INTEGRA announces $10,000 contribution to Dana-Farber Cancer Institute

Following the launch of its limited edition PIPETGIRL pink pipette controller in support of breast cancer research earlier this year - INTEGRA is pleased to announce it has made a $10,000 contribution to the Susan F Smith Center for Womens Cancers at the Dana-Farber Cancer Institute in Boston (MA, USA).

From INTEGRA Biosciences 6 Jul 2015

Boehringer Ingelheim LUX-Lung 8 trial reveals afatinib better than erlotinib to treat SCC of the lung

Boehringer Ingelheim today announced The Lancet Oncology has published results from the LUX-Lung 8 trial. LUX-Lung 8 is the largest, prospective Phase III head-to-head trial directly comparing two EGFR-directed treatments.

6 Jul 2015

ImmunoCellular, Novella partner to conduct ICT-107 phase 3 registration trial in patients with glioblastoma

ImmunoCellular Therapeutics, Ltd. today announced the establishment of an agreement with Novella Clinical (Novella), to conduct the phase 3 registration trial of ICT-107 in patients with newly diagnosed glioblastoma. Novella is a full-service, global clinical research organization (CRO) providing clinical trial services to small to mid-sized oncology companies.

6 Jul 2015

Researchers unravel mechanisms that enable accumulation of tumour promoting protease in stressed cancer cells

A mechanism beyond the level of gene regulation, which is often the underlying reason for changes in protein levels, does enable the strong accumulation of a tumour promoting protease in stressed cancer cells. The group of BIOSS researcher Prof. Dr. Thomas Reinheckel teamed up with BIOSS investigator Prof. Dr. Sabine Rospert and their colleagues from the University Medical Center Freiburg, Prof. Dr. Elmar Stickeler and Dr. Peter Bronsert, in order to unravel mechanisms by which stress-resistant production of cancer promoting proteins occurs.

6 Jul 2015

Cell News and Research

Study sheds light on how dengue virus adapts, causes outbreaks as it travels

City of Hope researchers to use patients' own modified T cells to treat advanced brain tumors

LSD1 enzyme turns off genes needed to maintain cancer stem cell properties in glioblastoma

Dental pulp stem cell transplants can contribute to peripheral nerve regeneration

Findings reveal new pathway to develop effective treatments and therapies for asthma, allergy

Researchers identify link between autoimmune diseases, medications and Long QT syndrome

AOSSM to present awards and grants to encourage cutting-edge research in orthopaedic sports medicine

New findings can help scientists generate tailor-made proteins optimized for use in optogenetics

Study uncovers complicated role of simple protein in spread of osteosarcoma

Study could provide paradigm shift in treatment of age-related disease, cancer

New therapeutic alternative found for children suffering from Ewing's sarcoma

Blood-borne molecule promotes age-related cognitive decline

New research suggests that Bcl-Rambo protein can protect against heart failure

University of Adelaide research may lead to new treatments for transplant patients

Transitioning Infrared Imaging into Clinical Use

Sialic acid attached to brain cells may affect brain structure, cause neurological problems

INTEGRA announces $10,000 contribution to Dana-Farber Cancer Institute

Boehringer Ingelheim LUX-Lung 8 trial reveals afatinib better than erlotinib to treat SCC of the lung

ImmunoCellular, Novella partner to conduct ICT-107 phase 3 registration trial in patients with glioblastoma

Researchers unravel mechanisms that enable accumulation of tumour promoting protease in stressed cancer cells

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