Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Active immune cells discovered in brain's cranial bone marrow fighting glioblastomas

A study uncovers the presence and activity of immune cells in glioblastoma, revealing new insights into brain tumor immunology and potential treatment avenues.

4 Aug 2024

Study links fungal heteroresistance to fatal bloodstream infections in bone marrow transplant patients

Emory researcher David Weiss has spent years studying a baffling phenomenon called heteroresistance, in which a tiny fraction of bacteria remain resistant to antibiotics, while the remainder succumb.

2 Aug 2024

St. Jude develops cost-effective genetic panel for pediatric cancer diagnosis

Scientists at St. Jude Children's Research Hospital have created a panel that is able to provide a diagnosis for >90% of pediatric cancer patients by sequencing 0.15% of the human genome.

1 Aug 2024

Discovery of potent immune cells near glioblastomas opens new avenues for treatment

Glioblastomas are highly aggressive, usually incurable brain tumors. If all therapeutic options are exhausted, patients have an average life expectancy of less than two years.

31 Jul 2024

Loss of Gα13 in B-cells linked to increased lymphoma risk due to dietary glutamine

Researchers find that the deletion of Gα13 in B-cells increases lymphoma risk by enhancing proliferation in gut-associated lymph nodes. Dietary glutamine significantly promotes these effects, highlighting a crucial link between diet and cancer.

29 Jul 2024

Exploring alemtuzumab in reduced-toxicity conditioning for Asian patients with inborn errors of immunity

Allogeneic hematopoietic cell transplantation (HCT) is a commonly used curative therapy for individuals with inborn errors of immunity (IEI).

28 Jul 2024

New guidelines expand BRCA testing and screening for men

More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women.

27 Jul 2024

Cord blood banking industry faces scrutiny over unproven claims and high costs

Some private UK biobanks may be misleading expectant parents about the value of storing umbilical cord blood to treat life-threatening diseases that may arise in their child in the future, reveals an investigation by The BMJ, published today.

25 Jul 2024

Breakthrough in acute myeloid leukemia treatment targets stem cells

Acute myeloid leukemia is one of the deadliest cancers. Leukemic stem cells responsible for the disease are highly resistant to treatment.

24 Jul 2024

Simple blood test may predict CAR-T therapy success in multiple myeloma

A simple blood test that measures the number of lymphocytes, a type of white blood cell in the body, may predict whether people who have relapsed multiple myeloma are going to respond well to CAR-T immunotherapy, according to new research from Weill Cornell Medicine, NewYork-Presbyterian, Columbia University and Icahn School of Medicine at Mount Sinai.

24 Jul 2024

Proteomic signatures enhance risk prediction for both common and rare diseases

Researchers have developed sparse prediction models combining plasma proteins and clinical data to predict the 10-year risk of 218 diseases. The study, involving over 41,000 participants, highlights the enhanced predictive power of proteomic signatures.

24 Jul 2024

Oral-gut axis: How mouth bacteria impact your overall health

A recent review in Nature Reviews Microbiology highlights how oral and gut microbiomes interact, impacting overall human health. Oral microorganisms can enter the gut, contributing to dysbiosis and various diseases, necessitating further research on these complex interactions.

24 Jul 2024

Unraveling the role of TAL1 and miR-146b-5p in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that arises from the malignant transformation of T-cell progenitors.

23 Jul 2024

Epigenetic insights into stroke-induced immunological changes

A stroke not only causes acute damage to the brain, but can also have long-term health implications for other organs - such as the heart.

23 Jul 2024

USC scientists transform B cells into cancer and HIV destroyers

USC scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes.

22 Jul 2024

New combined cell therapy for kidney transplants can help reduce donor-specific immune response

A new combined cell therapy for kidney transplants can help to reduce the donor-specific reaction against the transplanted organ without the need for maintenance triple immunosuppression.

22 Jul 2024

Insights into megakaryopoiesis regulation by plasmacytoid dendritic cells

Platelets play an essential role in wound healing. Underproduction can cause devastating bleeding, while overproduction increases the deadly risk of thromboses.

18 Jul 2024

COVID-19 leads to long-term changes in the immune system, study shows

In a study recently published in the renowned journal "Allergy", a MedUni Vienna research team shows that COVID-19 leads to considerable long-term changes in the immune system, even in mild cases.

15 Jul 2024

Common therapies contain different cell types, study finds

Researchers from University of California San Diego have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells. The results challenge the current "one-cell-cures-all" paradigm in orthopedic stem cell therapeutics and highlight the need for more informed and rigorous characterization of injectable stem cell therapies before they are marketed for use in patients.

13 Jul 2024

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced improvement with chemotherapy treatments.

11 Jul 2024

Bone Marrow News and Research

Further Reading

Active immune cells discovered in brain's cranial bone marrow fighting glioblastomas

Study links fungal heteroresistance to fatal bloodstream infections in bone marrow transplant patients

St. Jude develops cost-effective genetic panel for pediatric cancer diagnosis

Discovery of potent immune cells near glioblastomas opens new avenues for treatment

Loss of Gα13 in B-cells linked to increased lymphoma risk due to dietary glutamine

Exploring alemtuzumab in reduced-toxicity conditioning for Asian patients with inborn errors of immunity

New guidelines expand BRCA testing and screening for men

Cord blood banking industry faces scrutiny over unproven claims and high costs

Breakthrough in acute myeloid leukemia treatment targets stem cells

Simple blood test may predict CAR-T therapy success in multiple myeloma

Proteomic signatures enhance risk prediction for both common and rare diseases

Oral-gut axis: How mouth bacteria impact your overall health

Unraveling the role of TAL1 and miR-146b-5p in T-cell acute lymphoblastic leukemia

Epigenetic insights into stroke-induced immunological changes

USC scientists transform B cells into cancer and HIV destroyers

New combined cell therapy for kidney transplants can help reduce donor-specific immune response

Insights into megakaryopoiesis regulation by plasmacytoid dendritic cells

COVID-19 leads to long-term changes in the immune system, study shows

Common therapies contain different cell types, study finds

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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