Cell Metabolism News and Research

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YCC scientists uncover key to help treat many forms of cancer

Yale Cancer Center (YCC) scientists have uncovered the workings of a metabolic pathway or "gauge" that lets cancer cells detect when they have enough nutrients around them to grow.

11 Sep 2019

Fatty food changes the brain to affect homeostasis and metabolism

While we all know that eating fatty food pushes up our body weight, a new study now shows it also affects the way the brain keeps track of and corrects all metabolic irregularities in the body. Soon after tucking into a high-fat, high-carb meal – as soon as three days later – the hypothalamus shows inflammation.

10 Sep 2019

High-fat diets contribute to irregularities in hypothalamus region of the brain

Much research has pointed to how an unhealthy diet correlates to obesity, but has not explored how diet can bring about neurological changes in the brain.

9 Sep 2019

Researchers find a weak spot in cancer cells

Cancer cells form tumors. This statement, simple as it seems, hides a complex failure of normal immune responses that should eliminate tumor cells from the body before they ever form viable cancer masses.

28 Aug 2019

Ludwig study uncovers novel vulnerability in MYC-driven cancers

A Ludwig Cancer Research study has uncovered a novel vulnerability in tumors that are driven by a common cancer gene known as MYC. Such cancers, it found, are highly dependent on the cell's machinery for making fats and other lipids.

22 Aug 2019

Changes to mitochondria drive inflammation in type 2 diabetes, not glucose

To date, the underlying causes of inflammation in obesity and type 2 diabetes mellitus have been poorly understood, which has hampered efforts to develop treatments to prevent complications from a disease that is the third leading cause of death in the United States.

21 Aug 2019

Pitt researchers first to grow genetically modified miniature human livers in the lab

Researchers at the University of Pittsburgh School of Medicine are the first to grow genetically modified miniature human livers in the laboratory, to emulate human liver disease progression and test therapeutics.

7 Aug 2019

Researchers show how microorganisms protect themselves against free radicals

There are numerous different scenarios in which microorganisms are exposed to highly reactive molecules known as free radicals.

5 Aug 2019

Johns Hopkins researchers use nanotechnology to repair faulty brain circuits

Working with mouse and human tissue, Johns Hopkins Medicine researchers report new evidence that a protein pumped out of some — but not all — populations of “helper” cells in the brain, called astrocytes, plays a specific role in directing the formation of connections among neurons needed for learning and forming new memories.

31 Jul 2019

Novel therapeutic strategy for treating Lafora Disease shows promise in preclinical study

A team of scientists have designed and tested in mice a novel and promising therapeutic strategy for treating Lafora Disease, a fatal form of childhood epilepsy.

25 Jul 2019

Experts discuss 5G health risks as network switches on in the UK

As the 5G mobile network launches in some UK cities, experts discuss whether there is any reliable evidence to suggest people should be worried.

15 Jul 2019

Researchers identify potential drug target for multiple cancer types

A research team headed by scientists at University of California San Diego School of Medicine and the Ludwig Institute for Cancer Research at UC San Diego has identified an enzyme involved in remodeling the plasma membrane of multiple cancer cell types that is critical to both survival of tumors and their uncontrolled growth.

11 Jul 2019

RNA-binding protein SRSF3 appears to be key factor for proper heart contraction, survival

A team of scientists led by Dr Enrique Lara Pezzi at the Centro Nacional de Investigaciones Cardiovasculares has identified the RNA-binding protein SRSF3 as an essential factor for proper heart contraction and survival.

9 Jul 2019

Combining aerobic exercise and resistance training helps obese older adults preserve muscle mass

As obesity increases in aging Western populations, frailty—which is exacerbated by obesity—is becoming a greater health concern and a major healthcare cost.

4 Jul 2019

A metabolic intermediate in the uronic acid pathway impairs lung cancer metastasis

In a study published online in Nature on June 26, research teams led by Dr. YANG Weiwei at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences and Dr. LI Guohui from the Dalian Institute of Chemical Physics of CAS reported a new function of uridine diphosphate glucose (UDP-glucose), a metabolic intermediate in the uronic acid pathway: It impairs lung cancer metastasis by accelerating SNAI1 mRNA decay.

27 Jun 2019