Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

Trial shows no meaningful gains with mavacamten in nonobstructive hypertrophic cardiomyopathy

Mavacamten treatment at 48 weeks was not associated with significant improvements in patient-reported health status or peak oxygen consumption compared with placebo in patients with symptomatic nonobstructive hypertrophic cardiomyopathy, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

Vericiguat reduces mortality and hospitalizations in a broad range of patients with HFrEF

Vericiguat reduced the risk of cardiovascular mortality, heart failure (HF) hospitalizations and all-cause mortality across a broad range of patients with HF and reduced ejection fraction (HFrEF), according to a pooled analysis presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

New trial shows benefit of digitoxin in patients with severe heart failure symptoms

Digitoxin reduced the risk of a composite of all-cause death and hospitalization for worsening heart failure (HF) among patients with advanced HF and a reduced ejection fraction (HFrEF), according to a late-breaking trial presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

$Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction$

Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction

Beta-blocker therapy significantly reduced a composite endpoint of all-cause mortality, new myocardial infarction (MI) and heart failure (HF) compared with no beta-blocker therapy in the subgroup of patients with MI and mildly reduced left ventricular ejection fraction (LVEF), according to an individual patient data meta-analysis presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

ESC releases new guidance on lipid management to reduce cardiovascular risk

New ESC/EAS Focused Update to Guidelines, about how best to manage lipid levels in patients to reduce cardiovascular risk, recommends the use of new cardiovascular risk predication algorithms. The update was published today at ESC Congress 2025.

30 Aug 2025

New ESC guidelines prioritize women's autonomy in high-risk pregnancies

Updated ESC Guidelines, published today at ESC Congress 2025, put a focus on a woman's autonomy in making her own reproductive choices by promoting a transparent dialogue and shared decision-making for pregnancies that are high-risk for an adverse maternal and/or fetal event.

30 Aug 2025

REBOOT trial finds no benefit of beta blockers after uncomplicated heart attacks

Beta blockers-drugs commonly prescribed for a range of cardiac conditions, including heart attacks-provide no clinical benefit for patients who have had an uncomplicated myocardial infarction with preserved heart function.

30 Aug 2025

Daily use of low-dose colchicine may slow growth of blood mutations linked to disease

Taking low-dose colchicine daily may slow the progression of a common acquired gene mutation found in the blood of older adults that can lead to certain blood cancers and increased risk of cardiovascular disease, according to a subanalysis of the LoDoCo2 trial published in JACC, the flagship journal of the American College of Cardiology, and simultaneously presented at ESC Congress 2025.

29 Aug 2025

What are the benefits of chewing gum beyond oral health?

Chewing gum offers health benefits beyond oral care, enhancing performance and recovery, but research gaps for children and seniors need addressing.

29 Aug 2025

PREVENT equations provide more accurate risk estimates and support personalized hypertension care

Using the Predicting Risk of cardiovascular disease EVENTs (PREVENT™) equations provides more accurate risk estimates and supports personalized treatment for adults with high blood pressure or hypertension, according to a new scientific statement published today in the American Heart Association's peer-reviewed journals Circulation and Hypertension, and in JACC, the flagship journal of the American College of Cardiology.

28 Aug 2025

GLP-1 receptor agonists improve heart failure outcomes and reduce environmental impact

New research has found that the use of GLP-1 receptor agonists, a class of medications commonly prescribed for patients with obesity and diabetes, reduces the environmental footprint of healthcare and clinical outcomes when used to treat heart failure.

27 Aug 2025

Virtual care program provides continuous cardiometabolic support for heart failure patients at home

With chronic disease rates rising across the U.S., healthcare systems face ongoing challenges in reducing hospital stays and readmissions.

26 Aug 2025

New guidelines highlight importance of vaccination for heart patients

The American College of Cardiology has issued Concise Clinical Guidance (CCG) recommending vaccines to protect adults with heart disease against respiratory illness, including influenza, COVID-19 and RSV, and other diseases where vaccination is shown to offer cardiovascular protective benefits.

26 Aug 2025

Fat location, not BMI, drives heart ageing risk in men and women

Researchers using UK Biobank imaging data found that where fat is stored in the body, not just how much, determines cardiovascular ageing. Visceral, liver, and muscle fat accelerate ageing, while gynoid fat protects women before menopause.

25 Aug 2025

Regular sleep schedule linked to better outcomes after heart failure

People recovering from heart failure should consider improving the regularity of their sleep, a study led by Oregon Health & Science University suggests.

21 Aug 2025

Breakthroughs in diagnosis and therapy for transthyretin amyloidosis

Transthyretin amyloidosis (ATTR) is caused by the misfolding and aggregation of the transthyretin (TTR) protein, leading to multi-organ damage.

21 Aug 2025

Cardiovascular health declines in older adults with heart conditions

U.S. adults, ages 65 and older, with high blood pressure, heart failure or stroke had significant declines in cardiovascular health, according to new research published today in the Journal of the American Heart Association, an open-access, peer-reviewed journal of the American Heart Association.

20 Aug 2025

Young adults with bipolar disorder show signs of early heart dysfunction

Cardiovascular disease is the leading cause of premature deaths in patients with bipolar disorder worldwide.

19 Aug 2025

American College of Cardiology establishes a digital hypertrophic cardiomyopathy registry

The American College of Cardiology has established a digital hypertrophic cardiomyopathy (HCM) registry to learn more about one of the most common genetic cardiovascular diseases and provide more equitable access to treatment and care.

19 Aug 2025

Aggressive blood pressure management offers greater health benefits

Research led by investigators at Mass General Brigham suggests that the health benefits of more aggressive blood pressure control outweigh concerns about overtreating people with high blood pressure readings. Results of the simulation study are published in Annals of Internal Medicine.

19 Aug 2025

Heart Failure News and Research

Further Reading

Trial shows no meaningful gains with mavacamten in nonobstructive hypertrophic cardiomyopathy

Vericiguat reduces mortality and hospitalizations in a broad range of patients with HFrEF

New trial shows benefit of digitoxin in patients with severe heart failure symptoms

Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction

ESC releases new guidance on lipid management to reduce cardiovascular risk

New ESC guidelines prioritize women's autonomy in high-risk pregnancies

REBOOT trial finds no benefit of beta blockers after uncomplicated heart attacks

Daily use of low-dose colchicine may slow growth of blood mutations linked to disease

What are the benefits of chewing gum beyond oral health?

PREVENT equations provide more accurate risk estimates and support personalized hypertension care

GLP-1 receptor agonists improve heart failure outcomes and reduce environmental impact

Virtual care program provides continuous cardiometabolic support for heart failure patients at home

New guidelines highlight importance of vaccination for heart patients

Fat location, not BMI, drives heart ageing risk in men and women

Regular sleep schedule linked to better outcomes after heart failure

Breakthroughs in diagnosis and therapy for transthyretin amyloidosis

Cardiovascular health declines in older adults with heart conditions

Young adults with bipolar disorder show signs of early heart dysfunction

American College of Cardiology establishes a digital hypertrophic cardiomyopathy registry

Aggressive blood pressure management offers greater health benefits

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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