Myeloid Leukemia News and Research

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Myeloid Leukemia is an aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myelogenous leukemia, acute nonlymphocytic leukemia, AML, and ANLL.

Discovery of combination protein leads to first-in-human clinical trial for leukemia

The discovery of tri-specific natural killer engagers (TriKE™), a combination protein that bridges an immune cell and a tumor cell to drive tumor cell killing power exponentially, has led to a new Phase I, first-in-human study to treat leukemia.

20 Sep 2019

5 million gift will help create Edward P. Evans Center for MDS at Dana-Farber

A $5 million gift from the Edward P. Evans Foundation will create the Edward P. Evans Center for Myelodysplastic Syndromes at Dana-Farber Cancer Institute.

17 Sep 2019

Leukemia is not just one disease

An estimated 61,780 new cases of leukemia will be diagnosed in the United States this year, with some 2,000 cases in New Jersey, according to the American Cancer Society.

30 Aug 2019

Researchers find a weak spot in cancer cells

Cancer cells form tumors. This statement, simple as it seems, hides a complex failure of normal immune responses that should eliminate tumor cells from the body before they ever form viable cancer masses.

28 Aug 2019

Scientists reveal cancer cells' immune weak spot

Scientists have found a vulnerability in cancer cells that could make them more susceptible to being destroyed by the immune system, according to a new report in eLife.

27 Aug 2019

Removing tumor's protective wall could help boost the effects of cancer treatments

Scientists may have found a way to pull down the protective wall that surrounds tumors, potentially re-exposing them to the killing power of the immune system and immunotherapy treatments, according to a study part funded by Cancer Research UK and published in EBioMedicine today (Monday).

26 Aug 2019

Cancer stem cells elude the body's immune cells by deactivating danger detector

Acute myeloid leukemia stem cells elude the body's immune cells by deactivating a danger detector. The underlying mechanisms and the potential new therapeutic approaches that this gives rise to have been detailed in the journal Nature by researchers from the University of Basel and University Hospital Basel in collaboration with colleagues in Germany.

18 Jul 2019

Researchers identify gene mutations linked to leukemia in children with Down's syndrome

Researchers at the University of Oxford, in collaboration with colleagues from Hannover Medical School and Martin-Luther-University Halle-Wittenberg, have discovered the specific gene mutations that are required for the development of leukemia in children with Down's syndrome.

11 Jul 2019

Disparities in race, ethnicity, and status affect progress in cancer survival rates in youth

A new study in JNCI Cancer Spectrum finds that dramatic increases in cancer survival in adolescents and young adults are undermined by continuing disparities by race, ethnicity, and socioeconomic status.

12 Jun 2019

Study shows how SIRT1 plays key role in maintaining the regenerative potential of leukemic stem cells

Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure.

11 Jun 2019

IU researchers, collaborators receive grant to develop immunotherapy treatments for cancer

A team of researchers from Indiana University and Memorial Sloan Kettering Cancer Center have been awarded a $4.1 million National Cancer Institute "Cancer Moonshot" grant to develop immunotherapy treatments for cancer in children and adolescents, especially those with leukemia.

31 May 2019

Researchers map bone-marrow microenvironment to shed new light on leukemia

Stem cells are surrounded and protected by the stem-cell niche - the microenvironment - of the tissue in which they are found.

24 May 2019

Researchers identify why lymphoma patients may become resistant to specific drug

With more targeted therapies being approved each year for cancer, the development of drug resistance to these agents is a growing concern.

16 May 2019

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma.

9 May 2019

New findings about aggressive blood cancer may help develop drugs with less harmful side effects

New findings about a fatal form of blood cancer could aid the development of new drugs with significantly less harmful side effects than existing chemotherapy.

26 Apr 2019

Overlooked part of cell’s internal machinery may hold key to treating acute myeloid leukemia

Many individuals forced to fight an exceptionally aggressive form of the blood cancer acute myeloid leukemia (AML) don't survive more than five years.

22 Apr 2019

CRISPR-scanning could lead to more effective treatments for cancer

11,000 people are predicted to die from acute myeloid leukemia in 2019, according to the American Cancer Society. The cancer starts in the bone marrow. There, mutated genes fail to prevent blood cells from replicating again and again and again, growing tumors.

16 Apr 2019

Research reveals genomic basis of acute erythroid leukemia

Acute erythroid leukemia is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children's Research Hospital that appears today in the journal Nature Genetics.

30 Mar 2019

Chemistry researchers patent new method for making anti-leukemia compounds

Chemistry researchers at Oregon State University have patented a method for making anti-leukemia compounds that until now have only been available via an Asian tree that produces them.

21 Mar 2019

New Australian drug trial achieves remarkable results in patients with acute myeloid leukemia

The prognosis for older patients with acute myeloid leukemia is poor: very few achieve remission and for those that don't the option is largely palliative.