Oncogene News and Research

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An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Surgery and radiation remove, kill, or damage cancer cells in a certain area. But chemotherapy -- which uses medicines or drugs to treat cancer -- can work throughout the whole body, killing cancer cells that have spread far from the original tumor.

2 May 2017

Researchers discover new mechanism that causes chronic intestinal inflammation

Researchers at the University Medical Center of Johannes Gutenberg University Mainz and the German Research Center for Environmental Health, Helmholtz Zentrum München have discovered that too much of the oncogene Bcl-3 leads to chronic intestinal diseases.

28 Apr 2017

Researchers identify novel molecular mechanism involved in progression, metastasis of TNBC

University of Tsukuba-led researchers identified a novel molecular mechanism involved in progression and metastasis in the most aggressive form of breast cancer.

21 Apr 2017

New study illuminates dark side of p53 gene in cancer

The gene p53 is the most commonly mutated gene in cancer - it is p53's job to monitor cells for DNA damage and to mark damaged cells for destruction and so cancer cells with mutated DNA must disable p53 before it disables them.

3 Apr 2017

Researchers discover how epigenetic lesion can lead to T-cell acute lymphoblastic leukemia

Researchers from the Epigenetics and Cancer Biology Program led by Dr. Manel Esteller at the Bellvitge Biomedical Research Institute have discovered how an epigenetic lesion can lead to T-cell acute lymphoblastic leukemia.

30 Mar 2017

Researchers pinpoint Jumonji protein as key to Ewing's Sarcoma spread

By the time Ewing's Sarcoma is diagnosed, primarily in teens and young adults, it has often spread from its primary site to other parts of the body, making it difficult to treat.

24 Mar 2017

Study sheds light on cellular mechanisms that enable prostate cancer cells to form secondary tumours

New King's College London research sheds light on the cellular mechanisms which enable cancer cells to escape the prostate and spread to other parts of the body.

20 Mar 2017

SETD8 enzyme protects against cellular senescence, research reveals

An enzyme that blocks cellular senescence and its mechanisms has been discovered by a research team from Kumamoto University, Japan. They found that a reduction of the enzyme SETD8, which regulates cell proliferation and gene function, results in the promotion of cell aging features.

8 Mar 2017

Rheumatoid arthritis drug blocks metabolic pathway, reduces breast cancer tumors in mice

Mount Sinai researchers have discovered that a rheumatoid arthritis drug can block a metabolic pathway that occurs in tumors with a common cancer-causing gene mutation, offering a new possible therapy for aggressive cancers with few therapeutic options, according to a study to be published in Cancer Discovery.

3 Mar 2017

Blocking protein found on surface of ovarian cancer cells could prevent metastasis, research suggests

Blocking a protein found on the surface of ovarian cancer cells could prevent or reduce the spread of the disease to other organs, according to new research at the University of Illinois at Chicago.

3 Mar 2017

KRAS ‘imbalances’ that emerge over time may influence cancer treatment response

Choosing among cancer treatments increasingly involves determining whether tumor cells harbor specific, mutated "oncogenes" that drive abnormal growth and that may also be especially vulnerable or resistant to particular drugs.

28 Feb 2017

Huddersfield researchers discover cancer curing molecule that opens door for highly-effective treatment

SCIENTISTS at the University of Huddersfield are the first to arrive at a deep understanding of a molecule that destroys cancerous tumours without harming healthy cell tissue.

27 Feb 2017

Researchers identify novel gene critical to development of lung and pancreatic cancer

Researchers at the Center for Applied Medical Research of the University of Navarra have identified a critical gene, FOSL1, in the development of lung and pancreatic cancer.

22 Feb 2017

Gene expression patterns could help predict treatment for breast cancer, research shows

A Michigan State University breast cancer researcher has shown that effective treatment options can be predicted based on the way certain breast cancer genes act or express themselves.

21 Feb 2017

Researchers show how metabolism drives proliferation of tumor cells

The metabolic state of tumor cells contributes to signals that control the proliferation of tumor cells. Already the German biochemist and Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism.

20 Feb 2017

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted.

9 Feb 2017

Mayo Clinic to test vaccine for providing lifelong immunity against precancerous breast lesions

Only about 35 percent of precancerous breast lesions morph into cancer if untreated, but physicians cannot identify which lesions are potentially dangerous.

2 Feb 2017

Caspase-2 enzyme deficiency linked to higher cancer risk

Researchers from the Centre for Cancer Biology at the University of South Australia have found that a deficiency of caspase-2 enzymes place people at a higher risk of developing tumours.

25 Jan 2017

Study provides scientific insight into metastatic patterns of EGFR mutated NSCLCs

The discovery of several different subtypes of Non Small Cell Lung Cancer (NSCLC), the most frequent form of lung cancer, has been a major breakthrough in the fight against the leading cause of cancer-related death worldwide.

20 Jan 2017

Roswell Park researchers identify gene signatures that may help predict fatal prostate cancers

Standard therapy for prostate cancer, the third-leading cause of cancer-related deaths in American men, is based on blocking androgens, the male sex hormones.

11 Jan 2017