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New insight into meningioma - possibility of targeted therapy

A new study published in the journal Oncotarget shows that certain mutations in the brain tumor called meningioma may help identify patients who have a better chance of recovery. This could help physicians make better clinical decisions based on more accurate diagnoses. It has also unveiled some of the genes that go wrong in meningiomas, as well as showing how targeted therapy could one day help fight this tumor.

7 Oct 2019

Carnegie Mellon and Yale win NIH grant to advance gene editing technique

A research team from Carnegie Mellon University and Yale University will advance their innovative, synthetic nucleic acid-based gene editing technique under a new grant from the National Institutes of Health's Somatic Cell Genome Editing Program.

7 Oct 2019

Research provides new insights into tumorigenesis of meningioma

The identification of oncogenic mutations has provided further insights into the tumorigenesis of meningioma and the possibility of targeted therapy.

5 Oct 2019

The atomic-level structure of DNA polymerase delta – the enzyme behind DNA replication

A new study has revealed how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that can be transmitted through the generations.

4 Oct 2019

How mothers transfer the DNA inside their mitochondria to their babies

A recent study has revealed how DNA inside the cell's powerhouse comes from the mother's side.

4 Oct 2019

Scientists uncover the cause of a rare fatal nerve disease

A new study has revealed the cause of Pelizaeus-Merzbacher syndrome and how simply adding a chemical that binds to iron, so it can be removed from the cell, enables the sick cells to grow back.

4 Oct 2019

Study may help in personalizing treatment for lung cancer, develop new drugs

Researchers at the University of Copenhagen have used highly sophisticated molecular analyses to identify key proteins in the signaling pathways that cancers use to spread in the body.

4 Oct 2019

Researchers identify gene mutation that causes musculoskeletal problems in children

Researchers have identified a gene mutation that causes developmental delay, intellectual disability, behavioral abnormalities and musculoskeletal problems in children. The newly diagnosed condition, called NKAP-related syndrome, arises from mutations in the NKAP gene, which plays a key role in human development.

3 Oct 2019

Multi-gene testing at point of diagnosis can save all women with breast cancer

A lifetime model evaluating the financial, health and social impact of multi-gene testing (BRCA1/2/PALB2) at diagnosis for all breast cancer patients was found to be extremely cost effective for both UK and US health systems.

3 Oct 2019

Innovative drug treatment developed for familial adenomatous polyposis

Researchers from Tel Aviv University and Tel Aviv Sourasky Medical Center (Ichilov Hospital) have developed an innovative drug treatment for familial adenomatous polyposis (FAP), a rare, inherited condition that affects adolescents and young adults and often leads to colorectal cancer.

3 Oct 2019

Researchers discover metabolic vulnerability in cancer cells with mutated spliceosomes

A research team from the Johns Hopkins Kimmel Cancer Center reports it has discovered a metabolic vulnerability in multiple types of cancer cells that bear a common genetic mutation affecting cellular machines called spliceosomes.

From Johns Hopkins Medicine 3 Oct 2019

Novel viral vector improves gene therapy for sickle cell disease

Researchers at the National Institutes of Health (NIH) have developed a unique, improved lentiviral vector for use in gene therapy for sickle cell disease.

3 Oct 2019

Two cell mutations contribute to the development of acute myeloid leukemia

Sometimes the whole is greater than the sum of its parts. Researchers at Cold Spring Harbor Laboratory have discovered that two cell mutations, already harmful alone, enhance one another's effects, contributing to the development of the deadly blood cancer acute myeloid leukemia (AML).

3 Oct 2019

Researchers make breakthrough in gene therapy for sickle cell disease

Researchers at the National Institutes of Health have developed a new and improved viral vector--a virus-based vehicle that delivers therapeutic genes--for use in gene therapy for sickle cell disease.

2 Oct 2019

Maternal exposure to pollutants can lead to multigenerational weakening of the immune system

New research shows that maternal exposure to a common and ubiquitous form of industrial pollution can harm the immune system of offspring and that this injury is passed along to subsequent generations, weakening the body's defenses against infections such as the influenza virus.

2 Oct 2019

Using AI to transform drug discovery in a big way

According to the National Cancer Institute, approximately 38 percent of men and women will be diagnosed with cancer at some point in their lives.

1 Oct 2019

Findings could open up new research avenues into how heme tolerance occurs in humans

Most people have some idea of how important iron is to their health, but Iqbal Hamza, professor in Animal and Avian Sciences, has made his seventeen-year career at the University of Maryland all about the study of iron and heme trafficking and regulation in the body.

1 Oct 2019

Brazilian researchers identify new species of parasite in fatal case of visceral leishmaniasis

Brazilian researchers believe they have identified in patients treated at the University Hospital (HU) in Aracaju, state of Sergipe, a new species of parasite that can cause a disease similar to visceral leishmaniasis but is resistant to the treatments currently available.

1 Oct 2019

New method for studying individual cells could lead to earlier detection of diseases

Researchers in Sweden and the U.S. have devised a new method for studying individual cells in human tissue, which could lead to even earlier detection of diseases such as cancer and ALS. The method offers a 1,400-fold increase in spatial resolution.

1 Oct 2019

New insight into cause of Charcot-Marie-Tooth disease

The nervous system is the body’s control center, which is extremely fast in decoding messages from the different nerves in the body. This network should be intact and healthy. When something is wrong with the network, it affects the brain’s main functions.

1 Oct 2019