Preclinical News and Research

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Feeling sleepy during the day could predict Alzheimer's disease finds study

In a new study, researchers have shown that excessive sleepiness during the day time among elderly who had normal mental acuity and cognitive powers is associated with the buildup of amyloid plaques in the brain that is typical of Alzheimer’s disease.

13 Mar 2018

Pain begins differently for men and women at the cellular level, research says

New research from The University of Texas at Dallas supports the growing consensus that pain begins differently for men and women at the cellular level.

6 Mar 2018

Helmet use linked to lower likelihood of cervical spine injury during motorcycle crash

Despite claims that helmets do not protect the cervical spine during a motorcycle crash and may even increase the risk of injury, researchers from the University of Wisconsin Hospitals and Clinics in Madison found that, during an accident, helmet use lowers the likelihood of cervical spine injury, particularly fractures of the cervical vertebrae.

6 Mar 2018

One-month antibiotic regimen to prevent TB as safe, effective as nine-month therapy for HIV patients

A one-month antibiotic regimen to prevent active tuberculosis (TB) disease was at least as safe and effective as the standard nine-month therapy for people living with HIV, according to the results of a large international clinical trial.

6 Mar 2018

NETRF awards six new research grants to improve treatments for neuroendocrine tumors

The Neuroendocrine Tumor Research Foundation today awarded six new research grants totaling $1.85 million to leading academic institutions around the world.

5 Mar 2018

New compounds targeting epigenetics show promise in lymphoma patients

New compounds targeting epigenetics have shown remarkable early activity in patients with lymphoma, according to data presented at the TAT (Targeted Anticancer Therapies) International Congress 2018 in Paris, France.

5 Mar 2018

Unique progenitor cells in the pancreas have potential to develop glucose-responsive beta cells

Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine have confirmed the existence of progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells.

28 Feb 2018

UC receives $1.75 million grant for epilepsy research

Research scientist Jianxiong Jiang, PhD, doesn't just want to treat acquired epilepsy...he hopes to prevent it.

27 Feb 2018

Children from low-income areas have poor outcomes after heart surgery, study finds

Children from low-income neighborhoods had a higher mortality rate and higher hospital costs after heart surgery compared with those from higher-income neighborhoods, found a national study of more than 86,000 kids with congenital heart disease.

24 Feb 2018

Cell therapy for heart disease caused by muscular dystrophy also improves limb strength, study shows

Injections of cardiac progenitor cells help reverse the fatal heart disease caused by Duchenne muscular dystrophy and also lead to improved limb strength and movement ability, a new study shows.

23 Feb 2018

Clinical trial shows safety of promising TSRI stroke drug

A preliminary Phase 2 clinical trial has demonstrated that patients with acute ischemic stroke, the most common type of stroke, can safely tolerate high doses of 3K3A-APC, a promising anti-stroke drug invented at The Scripps Research Institute.

20 Feb 2018

AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies

AbbVie, a global biopharmaceutical company, and Voyager Therapeutics, Inc., a clinical-stage gene therapy company, today announced that they have entered into an exclusive strategic collaboration and option agreement to develop and commercialize vectorized antibodies directed against tau for the treatment of Alzheimer's disease and other neurodegenerative diseases.

20 Feb 2018

Oncolytic virus alerts the immune system to attack tumors

A new UC San Francisco study has shown that a cancer-killing virus currently in clinical trials may function as a cancer vaccine - in addition to killing some cancer cells directly, the virus alerts the immune system to the presence of a tumor, triggering a powerful, widespread immune response that kills cancer cells far outside the virus-infected region.

14 Feb 2018

Study reports longer survival for obese men with metastatic melanoma

Obese patients with metastatic melanoma who are treated with targeted or immune therapies live significantly longer than those with a normal body mass index, investigators report in a study published in Lancet Oncology of 1,918 patients in six independent clinical cohorts.

13 Feb 2018

UNC gene therapy scientists uncover viral barcode to penetrate blood-brain barrier

Gene therapies promise to revolutionize the treatment of many diseases, including neurological diseases such as ALS. But the small viruses that deliver therapeutic genes can have adverse side effects at high doses.

11 Feb 2018

Far-UVC light may offer solution to eradicating airborne flu viruses

Continuous low doses of far ultraviolet C light can kill airborne flu viruses without harming human tissues, according to a new study at the Center for Radiological Research at Columbia University Irving Medical Center.

9 Feb 2018

Researchers develop novel antibody-based therapy to treat organ fibrosis

Fibrosis can be triggered by many events- surgery, injury, disease- but regardless of the cause, it's characterized by accumulating masses of collagen-packed scar tissue that can permanently damage compromised organs.

6 Feb 2018

Asynt’s DrySyn MAXI heating system used for reproducible scale-up of medicinal chemistry reactions

Asynt reports that medicinal chemistry specialists Charnwood Molecular (Loughborough UK) have been using the DrySyn MAXI heating system to successfully and reproducibly scale up syntheses within their contract research laboratories.

6 Feb 2018

Researchers find new way to accelerate wound healing

Researchers at Uppsala University and SLU have found a new way of accelerating wound healing. The technology and the mode of action method published in the highly ranked journal PNAS involves using lactic acid bacteria as vectors to produce and deliver a human chemokine on site in the wounds.

5 Feb 2018

Researchers devise strategies to target glioma stem cells that could improve patient survival

Glioblastoma multiforme is the most common and aggressive primary brain tumor and has one of the worst survival rates of all cancers.

5 Feb 2018

Preclinical News and Research

Feeling sleepy during the day could predict Alzheimer's disease finds study

Pain begins differently for men and women at the cellular level, research says

Helmet use linked to lower likelihood of cervical spine injury during motorcycle crash

One-month antibiotic regimen to prevent TB as safe, effective as nine-month therapy for HIV patients

NETRF awards six new research grants to improve treatments for neuroendocrine tumors

New compounds targeting epigenetics show promise in lymphoma patients

Unique progenitor cells in the pancreas have potential to develop glucose-responsive beta cells

UC receives $1.75 million grant for epilepsy research

Children from low-income areas have poor outcomes after heart surgery, study finds

Cell therapy for heart disease caused by muscular dystrophy also improves limb strength, study shows

Clinical trial shows safety of promising TSRI stroke drug

AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies

Oncolytic virus alerts the immune system to attack tumors

Study reports longer survival for obese men with metastatic melanoma

UNC gene therapy scientists uncover viral barcode to penetrate blood-brain barrier

Far-UVC light may offer solution to eradicating airborne flu viruses

Researchers develop novel antibody-based therapy to treat organ fibrosis

Asynt’s DrySyn MAXI heating system used for reproducible scale-up of medicinal chemistry reactions

Researchers find new way to accelerate wound healing

Researchers devise strategies to target glioma stem cells that could improve patient survival

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