Clinical Trial News and Research

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Researchers examine the incidence of second primary lung cancers using National Lung Screening Trial data

Using data from the National Lung Screening Trial, researchers found that the incidence of second primary lung cancer was approximately 4% among the entire cohort of lung cancer patients and was as high as 8% among patients undergoing surgery for stage IA disease.

8 Aug 2022

The safety and preliminary efficacy of OP-101 in patients with severe COVID-19

Researchers assessed the impact of dendrimer nanotherapy in treating severe COVID-19.

8 Aug 2022

Human intestine-on-a-chip for modeling intestinal injury associated with a pediatric inflammatory disorder

News-Medical speaks to Dr. Cicely Fadel and Amir Bein about their latest research which involved the development of an Environmental Enteric Dysfunction (EED) Chip that reveals the effects of nutrition and genetics on disease in children

8 Aug 2022

BCG vaccine produces a "trained immunity response" which lasts more than a year

The immune boosting benefits of a tuberculosis vaccine can be seen in infants more than one year after vaccination, according to a new study.

8 Aug 2022

Varenicline and cytisine not more efficacious than nicotine to treat risky drinking and smoking, study says

A clinical trial to test whether three proven smoking cessation treatments could also reduce alcohol intake found no differences between the medications, but the rates of behavior change for alcohol consumption and smoking were high in all treatment groups. Results suggest these medications could play an important role to reduce alcohol use and smoking at the same time. Unexpectedly, nicotine replacement therapy performed as well as the prescription drugs varenicline and cytisine.

8 Aug 2022

New recommendations on how to determine eligibility criteria for lung cancer clinical trials

A clinical trial is only as powerful as its participants. For years, researchers have struggled to fill clinical trials and enroll sufficiently diverse groups of patients for results to reflect the broader population, in part because of stringent guidelines on who can participate.

5 Aug 2022

What does the future look like for TB care?

In this interview, we speak to Charles Wells from Gates MRI about their current research into tuberculosis (TB) as well as the recent updated guidelines for TB care.

5 Aug 2022

Monoclonal antibody protects U.S. adults from malaria, Phase 1 clinical trial shows

One injection of a candidate monoclonal antibody (mAb) known as L9LS was found to be safe and highly protective in U.S. adults exposed to the malaria parasite, according to results from a National Institutes of Health Phase 1 clinical trial published in The New England Journal of Medicine.

4 Aug 2022

Medical cannabis use may be common in women experiencing menopause-related symptoms

The legalization of medical cannabis has led to its use in treating a growing number of health problems. A new study suggests that it is becoming more common for women to use medical cannabis for menopause-related symptoms.

3 Aug 2022

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

Investigators from Cedars-Sinai Cancer have identified genetic signatures that could predict whether tumors in patients with bladder and other cancers will respond to immunotherapy.

3 Aug 2022

Integrated behavioral intervention effective at reducing depression and anxiety in obese adults

Results from a pilot clinical trial show that among a racially and ethnically diverse cohort of adults who were obese and depressed, an integrated behavioral intervention was more effective than usual care at reducing depression and associated anxiety symptoms than it was at promoting weight loss.

2 Aug 2022

New treatment gives hope for people challenged with chronic back pain

People challenged with chronic back pain have been given hope with a new treatment that focuses on retraining how the back and the brain communicate, a randomized controlled trial run by researchers at UNSW Sydney and Neuroscience Research Australia and several other Australian and European universities has shown.

2 Aug 2022

Hormonal treatment provides long-term benefit for premenopausal women with breast cancer

To investigate the long-term benefit of hormone-lowering treatment, researchers at Karolinska Institutet in Sweden have done a 20-year follow-up of premenopausal women with breast cancer.

2 Aug 2022

17 recommendations for better communication with study participants affected by early stopping of clinical trials

Participants in clinical trials can feel abandoned and adrift when their studies end early and they are the last to be informed, or they hear about it first from news or social media.

2 Aug 2022

TransCode and MD Anderson scientists collaborate to validate therapeutic and diagnostic candidates

The University of Texas MD Anderson Cancer Center and TransCode Therapeutics, Inc. today announced a strategic alliance to advance TransCode's pipeline of RNA-targeted oncology therapeutic and diagnostic candidates.

2 Aug 2022

UIC researchers receive $3.3 million to study telehealth behavioral interventions

Researchers at the University of Illinois Chicago have been awarded approximately $3.3 million from the National Institute on Aging to study telehealth behavioral interventions among adults 50 and older with excess weight and cardiometabolic risk factors.

1 Aug 2022

Alliance MCED Biobank Study may provide greater understanding of how to detect multiple cancers

The Alliance for Clinical Trials in Oncology, in partnership with the National Cancer Institute, part of the National Institutes of Health, today announced the opening of a new study for participant enrollment that aims to obtain a reference set of blood samples from newly diagnosed patients with cancer and healthy individuals without cancer to include in a future study to assess the utility of early cancer detection blood tests.

1 Aug 2022

Decoy ACE2 receptors broadly neutralize SARS-CoV-2 variants

Researchers review current developments in preclinical studies associated with recombinant ACE2 decoy receptors against coronaviruses.

31 Jul 2022

Is cannabidiol effective against COVID-19?

A new study discusses the utility of CBD in treating the inflammatory symptoms of COVID-19

31 Jul 2022

Higher insulin dose is positively linked with cancer incidence, study finds

Dr. Yuanjie Mao has led a study published in the Journal of the American Medical Association (JAMA) Oncology looking at the correlation between daily insulin dose and cancer incidence (the number of new cases) among patients with type 1 diabetes, finding that higher insulin dose is positively associated with cancer incidence and that the association is stronger among those with insulin resistance.

29 Jul 2022

Clinical Trial News and Research

Researchers examine the incidence of second primary lung cancers using National Lung Screening Trial data

The safety and preliminary efficacy of OP-101 in patients with severe COVID-19

Human intestine-on-a-chip for modeling intestinal injury associated with a pediatric inflammatory disorder

BCG vaccine produces a "trained immunity response" which lasts more than a year

Varenicline and cytisine not more efficacious than nicotine to treat risky drinking and smoking, study says

New recommendations on how to determine eligibility criteria for lung cancer clinical trials

What does the future look like for TB care?

Monoclonal antibody protects U.S. adults from malaria, Phase 1 clinical trial shows

Medical cannabis use may be common in women experiencing menopause-related symptoms

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

Integrated behavioral intervention effective at reducing depression and anxiety in obese adults

New treatment gives hope for people challenged with chronic back pain

Hormonal treatment provides long-term benefit for premenopausal women with breast cancer

17 recommendations for better communication with study participants affected by early stopping of clinical trials

TransCode and MD Anderson scientists collaborate to validate therapeutic and diagnostic candidates

UIC researchers receive $3.3 million to study telehealth behavioral interventions

Alliance MCED Biobank Study may provide greater understanding of how to detect multiple cancers

Decoy ACE2 receptors broadly neutralize SARS-CoV-2 variants

Is cannabidiol effective against COVID-19?

Higher insulin dose is positively linked with cancer incidence, study finds

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