Genetic Engineering News and Research

RSS

Researchers have identified the cellular receptor for the JC virus

Researchers funded in part by the National Institute of Neurological Disorders and Stroke (NINDS) have identified the cellular receptor for the JC virus, which causes the fatal neurological disease progressive multifocal leukoencephalopathy (PML).

17 Jan 2005

Low carbohydrate diet may prevent Alzheimer's disease

Researchers found that a low carbohydrate diet that reduced total caloric intake by 30% prevented the development of a fundamental feature of Alzheimer's disease (AD) in mice genetically engineered to develop the disease. The diet eliminated amyloid plaque development, which is the underlying pathology in AD.

12 Jan 2005

Novel vaccine that uses immune cells as factories to produce Her2/neu protein may offer a way to treat some breast cancers

Based on successful animal studies, a novel vaccine that uses immune cells as factories to produce Her2/neu protein may offer a way to treat some human breast cancers, say researchers at The University of Texas M. D. Anderson Cancer Center.

10 Jan 2005

Scientists identify genes that promote the growth and recurrence of skin cancer

Andrzej Dlugosz, M.D., a professor of dermatology in the U-M Medical School, and colleagues at the University of Michigan and the National Cancer Institute examined the functions of the Hedgehog (Hh) signaling pathway in basal cell carcinoma – the most common form of cancer – and uncovered a subset of tumor cells that were resistant to inhibition of the Hedgehog pathway.

10 Jan 2005

Gene sequencing explains why natural bioremediation 'bug' has big appetite for chlorinated pollutants

"The born-to-dechlorinate bug" is what Cornell University researchers called Dehalococcoides ethenogenes Strain 195 when they found the bacterium obligingly detoxifying the pollutant PCE, or perchloroethylene (a chlorinated solvent used for dry cleaning), in sludge from an Ithaca, N.Y., sewage treatment plant.

6 Jan 2005

Antibiotics protect nerves in mice by turning on genes

A family of antibiotics that includes penicillin may help prevent nerve damage and death in a wide variety of neurological diseases, including Lou Gehrig's disease, dementia, stroke, and epilepsy, Johns Hopkins researchers have found.

6 Jan 2005

Scientists have identified genes that promote the growth and recurrence of skin cancer

Dr. Andrzej Dlugosz and colleagues at the University of Michigan and the National Cancer Institute have examined the functions of the Hedgehog (Hh) signaling pathway in basal cell carcinoma, the most common form of cancer, and have uncovered a subset of tumor cells that are resistant to inhibition of the Hh pathway.

28 Dec 2004

Turning off cell suicide switch fails to stop prion damage

Researchers knew that prions, the misfolded proteins that cause mad cow disease and other brain disorders, were killing off a class of important brain cells in a transgenic mouse model. But when they found a way to rescue those cells, they were astonished to discover the mice still became sick.

21 Dec 2004

Blocking a key molecule protects breast implants, permanent catheters, pacemakers and artificial joints from rejection and damage by the body

Blocking a key molecule protects breast implants, permanent catheters, pacemakers, artificial joints, glucose sensors for diabetics, and other biomaterials from rejection and damage by the body, according to a study published this month in The American Journal of Pathology.

20 Dec 2004

Permanent resistance to antibiotics cannot be prevented

Dutch research has shown that the development of permanent resistance by bacteria and fungi against antibiotics cannot be prevented in the longer-term. The only solution is to reduce the dependence on antibiotics by using these less.

20 Dec 2004

Scientist develops way to deliver promising genetic tool into living cells

By exploiting an HIV protein that readily traverses cell membranes, Carnegie Mellon University scientists have developed a new way to introduce a gene-like molecule called a peptide nucleic acid (PNA) directly into live mammalian cells, including human embryonic stem (ES) cells.

6 Dec 2004

First live imaging of specialized immune system cells reveals new clues about body’s security system

To keep the body safe, the immune system enlists more than one form of protection. A circulating task force of immune system cells monitors the body’s periphery, and sends information back to field command centers — the lymph nodes — located at pivotal traffic points.

6 Dec 2004

Heart researchers have used gene therapy to bring failing rat hearts back to normal

Scientists led by Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine in Jefferson Medical College of Thomas Jefferson University in Philadelphia, used a virus to insert the gene for a protein called S100A1 into failing rat hearts.

4 Dec 2004

Potential vaccine for the deadly toxin ricin

A potential vaccine for the deadly toxin ricin, a "Category B" biological agent, will enter the first phase of clinical testing in coming weeks at UT Southwestern Medical Center at Dallas.

30 Nov 2004

Scientists have given blind nerve cells the ability to detect light

Scientists at the University of California, Berkeley, have given "blind" nerve cells the ability to detect light, paving the way for an innovative therapy that could restore sight to those who have lost it through disease.

24 Nov 2004

Researchers have discovered that by blocking a specific enzyme, it is possible to check the spread of cancer

A team of Danish researchers have discovered that by blocking a specific enzyme, it is possible to check the spread of cancer in the body. This finding may be the first step towards preventing deaths due to cancer spreading to other parts of the body.

23 Nov 2004

New research may lead to new treatments for spinal cord injury and multiple sclerosis

For the first time, researchers have used human embryonic stem cells to create new insulating tissue for nerve fibers in a live animal model – a finding that has potentially important implications for treatment of spinal cord injury and multiple sclerosis.

23 Nov 2004

Cells linked to asthma and eczema also help cure deadly illness in mice

Mast cells are immune cells known mostly for their unwanted effects: they cause the wheezing of asthma, the itching of eczema, the sneezing and runny nose of hay fever and, in extreme cases, the life-threatening shock of anaphylaxis.

20 Nov 2004

Research shows that even bacteria don't put their eggs in one basket

Diversification helps reduce overall risk by putting your eggs in more than one basket and is a strategy that strengthens groups of all kinds -- from forests challenged with environmental stress to stock market portfolios in uncertain times. Findings from University of Iowa researchers show that even bacteria have learned this important lesson.

16 Nov 2004

Mast cells can provide protection from a potentially deadly condition known as sepsis

14 Nov 2004