Mutation News and Research

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Intensive new combination therapy for ovarian cancer shows promising results

Researchers have found that more intensive chemotherapy maintenance for ovarian cancer could be beneficial for patients. The results of the study were presented at the ESMO Congress 2019 in Barcelona, Spain last weekend on the 28th of September.

30 Sep 2019

Lung cancer may soon be picked up by a blood test

A study presented at the ESMO Congress 2019 has revealed that a blood test may soon be able to pick up circulating tumor DNA to help avoid invasive tissue biopsies in lung cancer patients.

30 Sep 2019

Triplet therapy could benefit patients with BRAF-mutant metastatic colorectal cancer

Results presented today at the ESMO Congress 2019, Barcelona 27 September - 01 October, during the second Proffered Paper Session on Gastrointestinal tumors (colorectal) by VHIO's Director, Josep Tabernero, show that the triplet combination of the BRAF inhibitor, encorafenib, MEK inhibitor, binimetinib, and EGFR inhibitor, cetuximab, not only significantly improves overall survival but also increases objective response rates compared with standard of care in patients with BRAF V600E-mutant metastatic colorectal cancer.

30 Sep 2019

New trial shows improved survival for patients with advanced colorectal BRAF-mutant cancer

A clinical trial has shown that using a combination of three drugs that target a BRAF gene mutation in patients with mCRC effectively boosts overall survival.

30 Sep 2019

Stem cells derived from patients could lead to new treatments for congenital muscular dystrophies

Researchers at Queen Mary University of London and University College London have shown that using stem cells derived from patients could help find new treatments for a group of congenital muscular dystrophies.

30 Sep 2019

Study: Three-drug combination improves overall survival in patients with mCRC

The three-drug combination of encorafenib, binimetinib and cetuximab significantly improved overall survival (OS) in patients with BRAF-mutated metastatic colorectal cancer (mCRC), according to results of the BEACON CRC Phase III clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

30 Sep 2019

Study reveals molecular mechanism of cancer malignancy and development of leukemia

A Waseda University-led research uncovered the molecular mechanism of how a particular cancer-causing oncogene could trigger an onset of acute myeloid leukemia (AML).

30 Sep 2019

PARP inhibitor combined with chemotherapy increases survival for newly diagnosed ovarian cancer patients

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that initial treatment with the PARP inhibitor veliparib in combination with chemotherapy significantly increased progression-free survival for patients with newly diagnosed, metastatic high-grade serous ovarian cancer, according to the results of the VELIA trial.

28 Sep 2019

High-speed imaging technology reveals previously unseen details of living creatures

The Columbia team behind the revolutionary 3D SCAPE microscope announces today a new version of this high-speed imaging technology.

27 Sep 2019

DNA sequencing helps confirm breast cancer link between Leicester sisters

Two Leicester sisters who had their entire genomes sequenced in the hope of finding answers to their family history of breast cancer have learnt they both carry a genetic variant that significantly increases their risk of developing the disease.

27 Sep 2019

'A new era of drug discovery’: Company develops drug using AI

For the first time, a company has discovered a drug target and corresponding candidate using artificial intelligence (AI).

26 Sep 2019

Personal Genome Diagnostics applies CE mark to PGDx elio tissue complete assay

Personal Genome Diagnostics Inc. (PGDx), a leader in cancer genomics, today announced that it has applied the CE mark to the PGDx elio™ tissue complete assay.

26 Sep 2019

Experimental treatment shows early promise to help nearly half of DMD patients

A new therapeutic being tested by University of Alberta researchers is showing early promise as a more effective treatment that could help nearly half of patients with Duchenne muscular dystrophy.

25 Sep 2019

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

25 Sep 2019

7-year-old treated with FDA-approved gene therapy for Leber congenital amaurosis

When Zion Grant was 3 months old his mother Daisy Dodd noticed he wasn't tracking her with his eyes. Zion would fixate on a light in the room, but not on her face.

24 Sep 2019

Discovery provides potential therapeutic target for prostate cancers with PTEN mutation

PTEN, a tumor suppressor gene mutated in approximately 20% of primary prostate cancers, and in as many as 50% of androgen deprivation-resistant prostate cancers, relies on another gene, ARID4B, to function.

24 Sep 2019

Newly synthesized anticancer compound can block cancer signaling mechanism

Of the various different functions that proteins perform in a cell, a crucial one is the recognition and transmission of certain "signals," collectively referred to as signal transduction.

24 Sep 2019

New study shows how fungal biofilm morphology impacts lung disease

Findings from an innovative new study led by researchers at Dartmouth's Geisel School of Medicine and published this week in Nature Microbiology reveal that the way in which human fungal pathogens form colonies can significantly impact their ability to cause disease.

23 Sep 2019

U-M and Karmanos receive NCI grant to find new solutions for prostate cancer

Michigan's two elite cancer programs are joining forces to find new solutions for prostate cancer. The University of Michigan Rogel Cancer and the Barbara Ann Karmanos Cancer Institute have received a prestigious $9.2 million grant from the National Cancer Institute.

23 Sep 2019

New uses for CBD in genetic brain disorder

A new study has revealed that cannabidiol can help people with a rare brain condition called Angelman syndrome to improve their behavioral traits and to control seizures.

19 Sep 2019

Mutation News and Research

Intensive new combination therapy for ovarian cancer shows promising results

Lung cancer may soon be picked up by a blood test

Triplet therapy could benefit patients with BRAF-mutant metastatic colorectal cancer

New trial shows improved survival for patients with advanced colorectal BRAF-mutant cancer

Stem cells derived from patients could lead to new treatments for congenital muscular dystrophies

Study: Three-drug combination improves overall survival in patients with mCRC

Study reveals molecular mechanism of cancer malignancy and development of leukemia

PARP inhibitor combined with chemotherapy increases survival for newly diagnosed ovarian cancer patients

High-speed imaging technology reveals previously unseen details of living creatures

DNA sequencing helps confirm breast cancer link between Leicester sisters

'A new era of drug discovery’: Company develops drug using AI

Personal Genome Diagnostics applies CE mark to PGDx elio tissue complete assay

Experimental treatment shows early promise to help nearly half of DMD patients

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

7-year-old treated with FDA-approved gene therapy for Leber congenital amaurosis

Discovery provides potential therapeutic target for prostate cancers with PTEN mutation

Newly synthesized anticancer compound can block cancer signaling mechanism

New study shows how fungal biofilm morphology impacts lung disease

U-M and Karmanos receive NCI grant to find new solutions for prostate cancer

New uses for CBD in genetic brain disorder

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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