Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Blood test detects mild traumatic brain injury for up to a week

Researchers report findings of a blood biomarker that consistently detects mild to moderate traumatic brain injury for up to 7 days and quantifies the degree of damage.

31 Mar 2016

Researchers clarify potential transmissibility of Alzheimer's disease

MedUni Vienna researchers have published the results of a clarifying research study on the potential transmissibility of Alzheimer's disease. Although the protein associated with Alzheimer's disease, amyloid-β, might be transmissible under very unusual circumstances, this does not go along with a transmission of the clinical manifestation of Alzheimer's disease. The affected persons develop no clinical symptoms of the disease.

29 Mar 2016

Simple blood test can help detect evidence of concussions up to 7 days after injury

Researchers at Orlando Health detected evidence of concussions in patients up to 7 days after their injury using a simple blood test, according to a new study published in JAMA Neurology. The discovery could greatly expand the window for diagnosing concussions, especially in patients who experience a delayed onset of symptoms.

29 Mar 2016

BIDMC investigators identify precise 5-gene classifier for discriminating early pancreatic cancer

Pancreatic cancer, the fourth leading cause of cancer death in the United States, is often diagnosed at a late stage, when curative treatment is no longer possible. A team led by investigators at Beth Israel Deaconess Medical Center has now identified and validated an accurate 5-gene classifier for discriminating early pancreatic cancer from non-malignant tissue.

28 Mar 2016

MALDI tissue imaging spots early renal lipid changes in acute kidney injury

University of Alabama at Birmingham researchers have made a microscopic snapshot of the early renal lipid changes in acute kidney injury, using the laser-scanning method called MALDI tissue imaging to localize the changes.

24 Mar 2016

Blood test can predict risk of developing TB disease long before it manifests

A landmark study published this month in the leading medical journal, The Lancet, reports the discovery of a blood test that can predict whether someone is likely to develop tuberculosis (TB) disease, long before the disease manifests.

23 Mar 2016

OHSU researchers link infrequent computer use, brain imaging signs in early-stage Alzheimer's patients

A new study sheds light on a powerful tool that may detect signs of Alzheimer's disease before patients show any symptoms of cognitive decline: the home computer.

23 Mar 2016

Novel approach to cancer risk assessment maximizes public health benefits

Edward Calabrese, the University of Massachusetts Amherst environmental toxicologist who has been an outspoken critic of the current linear no-threshold (LNT) approach to risk assessment for radiation and toxic chemicals, now proposes a new approach integrating LNT with hormetic dose-response models.

23 Mar 2016

Only few U.S. adults maintain healthy lifestyle, research finds

Only 2.7 percent of the U.S. adult population achieves all four of some basic behavioral characteristics that researchers say would constitute a "healthy lifestyle" and help protect against cardiovascular disease, a recent study concluded.

22 Mar 2016

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

A common theme in medicine is that detecting a disease early on can lead to more effective treatments. This relies partly on luck that the patient gets screened at the right time, but more important is that the testing techniques are sensitive enough to register the minuscule hints that diseases leave in the blood stream.

21 Mar 2016

Value of PD-L1 testing in NSCLC debated

Two viewpoint articles published in JAMA Oncology provide opposing opinions on the benefit of testing for programmed death-ligand 1 expression in patients with non-small-cell lung cancer treated with checkpoint inhibitors.

18 Mar 2016

Sodium MRI could provide more detailed picture of tissue health and disease

MRI experts at The University of Nottingham win £1m grant to adapt scanning techniques to pick up sodium in the body. The research could lead to much more detailed MRI scans in the future with significant improvements to the diagnosis and treatment of many diseases.

18 Mar 2016

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Recently discovered biomarkers may provide valuable new approaches to monitoring immunosuppressive drug therapy in organ transplant recipients--with the potential for individualized therapy to reduce organ rejection and minimize side effects, according to a special article in the April issue of Therapeutic Drug Monitoring, official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

17 Mar 2016

Experimental drug improves survival rate of majority of lung cancer patients compared to standard chemotherapy

In global clinical trials, patients with advanced metastatic lung cancer who were treated with a targeted immunotherapy drug lived significantly longer and with fewer side effects than those who received standard second-line chemotherapy, according to a new Kaiser Permanente study published today in the journal The Lancet.

15 Mar 2016

New blood test may potentially facilitate detection of Alzheimer's disease at early stage

Today, Alzheimer's disease is diagnosed too late. In collaboration with a research team at the university and German Center for Neurogenerative Diseases in Göttingen, Researchers at Ruhr-Universität Bochum have developed a blood test that may potentially facilitate detection of Alzheimer's at an early stage. It is based on an immuno-chemical analysis using an infrared sensor.

15 Mar 2016

Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Researchers report photoimmunotherapy to be effective against elusive gastric cancer cells following transduction with the gene that expresses the extracellular domain protein of HER2. The results are published in the journal Small Molecule Therapeutics in February 2016.

15 Mar 2016

New microfluidic biosensor can identify white blood cells quickly for AIDS diagnosis

Researchers from the University of Illinois at Urbana-Champaign have developed a highly sensitive biosensor based on a differential immuno-capture technology that can detect sub-populations of white blood cells. As part of a small, disposable biochip, the microfluidic biosensor can count CD4+/CD8+ T cells quickly and accurately for AIDS diagnosis in the field.

14 Mar 2016

Fertility problems put men at increased risk of metabolic diseases

Men with fertility problems are at risk of metabolic diseases as they age, according to work being presented at the European Association of Urology conference in Munich

14 Mar 2016

NLRX1 protein could be new biomarker for colorectal cancer, find UNC Lineberger researchers

UNC Lineberger Comprehensive Cancer Center researchers have discovered that a deficiency in a key protein that regulates immune system warning signals could be a new biomarker for colorectal cancer, the second largest cancer killer in the United States. They believe the marker could be used to gauge response to a potential new treatment for the disease.

11 Mar 2016

VolitionRx's NuQ blood test accurately detects 86% of subjects with Idiopathic Pulmonary Fibrosis

VolitionRx Limited today announced preliminary data from a pilot study demonstrating that the Company’s NuQ® blood test detected 86% of subjects with a deadly lung disease, called Idiopathic Pulmonary Fibrosis (IPF).

10 Mar 2016

Biomarker News and Research

Further Reading

Blood test detects mild traumatic brain injury for up to a week

Researchers clarify potential transmissibility of Alzheimer's disease

Simple blood test can help detect evidence of concussions up to 7 days after injury

BIDMC investigators identify precise 5-gene classifier for discriminating early pancreatic cancer

MALDI tissue imaging spots early renal lipid changes in acute kidney injury

Blood test can predict risk of developing TB disease long before it manifests

OHSU researchers link infrequent computer use, brain imaging signs in early-stage Alzheimer's patients

Novel approach to cancer risk assessment maximizes public health benefits

Only few U.S. adults maintain healthy lifestyle, research finds

New ultra-sensitive technique shows promise as diagnostic tool for cancers, HIV

Value of PD-L1 testing in NSCLC debated

Sodium MRI could provide more detailed picture of tissue health and disease

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Experimental drug improves survival rate of majority of lung cancer patients compared to standard chemotherapy

New blood test may potentially facilitate detection of Alzheimer's disease at early stage

Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

New microfluidic biosensor can identify white blood cells quickly for AIDS diagnosis

Fertility problems put men at increased risk of metabolic diseases

NLRX1 protein could be new biomarker for colorectal cancer, find UNC Lineberger researchers

VolitionRx's NuQ blood test accurately detects 86% of subjects with Idiopathic Pulmonary Fibrosis

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