Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Small, sensitive biosensors could help personalize treatment for Alzheimer's disease

A portable biosensor that could show how disease is progressing in patients with Alzheimer's could greatly improve people's quality of life in the future, according to a new review published in Biosensors and Bioelectronics.

10 Mar 2016

PAH role proposed for left heart failure biomarker

Levels of galectin-3 are elevated in patients with pulmonary arterial hypertension and correlate with disease severity, research shows.

10 Mar 2016

Complex biomarker tests for molecularly targeted therapies lack evidentiary standards

Potentially useful biomarker tests for molecularly targeted therapies are not being adopted appropriately into clinical practice because of a lack of common evidentiary standards necessary for regulatory, reimbursement, and treatment decisions.

7 Mar 2016

Preliminary results of blood test to diagnose CTE during life published in Journal of Alzheimer's Disease

Exosome Sciences, Inc., in collaboration with majority shareholder Aethlon Medical, Inc. and investigators at Boston University and the University of Washington, announced today the published preliminary results of possibly the first blood test to detect the neurodegenerative disease, Chronic Traumatic Encephalopathy (CTE) during life.

7 Mar 2016

Expression of BIRC3 protein associated with poor survival, recurrent disease in GBM patients

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with low survival rates, with newly diagnosed patients surviving a median of 14 months and recurrent patients surviving a median of only 3 to 9 months. New therapeutic targets and biomarkers for prognosis are urgently needed.

7 Mar 2016

Study identifies biomarker that plays role in early stages of Alzheimer's disease

A multicenter study led by Christian Haass and Michael Ewers of Ludwig-Maximilians-Universitaet in Munich has identified a biomarker associated with the activation of an innate immune response to neural damage during early stages of Alzheimer's disease.

4 Mar 2016

FDA clearance expands clinical claims of Thermo Scientific B•R•A•H•M•S PCT biomarker for sepsis risk assessment

Thermo Fisher Scientific Inc., the world leader in serving science, today announced it has received clearance from the U.S. Food and Drug Administration that expands the clinical claims of the Thermo Scientific B·R·A·H·M·S PCT biomarker assay for sepsis risk assessment.

From Thermo Fisher Scientific Inc. 2 Mar 2016

Depression may be a systemic disease, say researchers

An international team of researchers lead by the University of Granada has scientifically proven, for the first time, that depression is associated with important alterations of the oxidative stress, so it should be considered a systemic disease.

2 Mar 2016

Omalizumab drug can be better targeted to treat people with severe asthma

Around five million people in the UK are currently being treated for asthma. Of these, a quarter of a million are unable to get good control of their condition, resulting in frequent, severe, or even life-threatening attacks. A new study brings hope to these patients by investigating whether the drug Omalizumab can be better targeted.

2 Mar 2016

Stemina developing new screening method to diagnose autism

A University of Wisconsin-Madison spinoff is screening blood samples in an effort to develop a biologically based method to diagnose autism.

2 Mar 2016

Researchers discover new biomarker that puts patients at higher risk for metastasis of uveal melanoma

A study by J. William Harbour, M.D., associate director for Basic Research and leader of the Eye Cancer Site Disease Group at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and colleagues published today in Clinical Cancer Research details the discovery of a biomarker that puts patients at a higher risk for metastasis of uveal melanoma.

2 Mar 2016

New study finds link between vitamin D deficiency and aggressive prostate cancer

A new study provides a major link between low levels of vitamin D and aggressive prostate cancer. Northwestern Medicine research showed deficient vitamin D blood levels in men can predict aggressive prostate cancer identified at the time of surgery.

2 Mar 2016

University of Louisville cardiologist on the verge of breakthrough in predicting heart disease in women

Heart disease is the leading cause of mortality in women worldwide, including in the United States. Although deaths from cardiovascular disease (CVD) in men have declined since the 1970s, the rates of death for women have not followed.

1 Mar 2016

P. gingivalis could be a novel risk factor for esophageal cancer

University of Louisville School of Dentistry researchers have found a bacterial species responsible for gum disease, Porphyromonas gingivalis, is present in 61 percent of patients with esophageal squamous cell carcinoma (ESCC).

27 Feb 2016

Elevated levels of particular proteins in cancer cells fuel growth and spread of different cancers

Researchers at University of California, San Diego School of Medicine and Moores Cancer Center, with colleagues in Spain and Germany, have unraveled how elevated levels of particular proteins in cancer cells trigger hyperactivity in other proteins, fueling the growth and spread of a variety of cancers.

27 Feb 2016

Omega-3 fatty acids can lower risk of breast cancer in postmenopausal obese women

Omega-3 fatty acids may lower the risk of breast cancer in postmenopausal obese women, according to researchers.

24 Feb 2016

EPFL researchers develop portable microfluidic diagnostic device to detect different diseases

When remote regions with limited health facilities experience an epidemic, they need portable diagnostic equipment that functions outside the hospital. As demand for such equipment grows, EPFL researchers have developed a low-cost and portable microfluidic diagnostic device. It has been tested on Ebola and can be used to detect many other diseases.

22 Feb 2016

Scientists resolve tumor heterogeneity using innovative DEPArray technology

Using the innovative DEPArray technology, scientists at Silicon Biosystems, a Bologna (Italy) and San Diego (CA, USA) based biotech company, were able to solve one of the biggest limitation in the study of cancer genetic: tumor samples heterogeneity.

22 Feb 2016

Novartis receives FDA Breakthrough Therapy designation for PKC412 (midostaurin)

Novartis announced today that the United States Food and Drug Administration has granted Breakthrough Therapy designation to PKC412 (midostaurin). PKC412 (midostaurin) is an investigational treatment for adults with newly-diagnosed AML who are FLT3 mutation-positive, as detected by an FDA-approved test, and who are eligible to receive standard induction and consolidation chemotherapy.

19 Feb 2016

Majority of LAHNC patients rely on lifestyle-altering cost-coping strategies to manage treatment

The majority of patients with locally advanced head and neck cancers (LAHNC) rely on cost-coping strategies that alter their lifestyle in order to manage the financial burden of their care, according to research presented at the 2016 Multidisciplinary Head and Neck Cancer Symposium.

19 Feb 2016

Biomarker News and Research

Further Reading

Small, sensitive biosensors could help personalize treatment for Alzheimer's disease

PAH role proposed for left heart failure biomarker

Complex biomarker tests for molecularly targeted therapies lack evidentiary standards

Preliminary results of blood test to diagnose CTE during life published in Journal of Alzheimer's Disease

Expression of BIRC3 protein associated with poor survival, recurrent disease in GBM patients

Study identifies biomarker that plays role in early stages of Alzheimer's disease

FDA clearance expands clinical claims of Thermo Scientific B•R•A•H•M•S PCT biomarker for sepsis risk assessment

Depression may be a systemic disease, say researchers

Omalizumab drug can be better targeted to treat people with severe asthma

Stemina developing new screening method to diagnose autism

Researchers discover new biomarker that puts patients at higher risk for metastasis of uveal melanoma

New study finds link between vitamin D deficiency and aggressive prostate cancer

University of Louisville cardiologist on the verge of breakthrough in predicting heart disease in women

P. gingivalis could be a novel risk factor for esophageal cancer

Elevated levels of particular proteins in cancer cells fuel growth and spread of different cancers

Omega-3 fatty acids can lower risk of breast cancer in postmenopausal obese women

EPFL researchers develop portable microfluidic diagnostic device to detect different diseases

Scientists resolve tumor heterogeneity using innovative DEPArray technology

Novartis receives FDA Breakthrough Therapy designation for PKC412 (midostaurin)

Majority of LAHNC patients rely on lifestyle-altering cost-coping strategies to manage treatment

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

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