Preclinical News and Research

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Study: Combination targeted therapy has high response rates in AML patients

Initial findings from a multi-national open-label phase Ib study of inhibitory drug therapy for relapsed or refractory acute myeloid leukemia (AML) have demonstrated a complete response in up to 50 percent patients say researchers at The University of Texas MD Anderson Cancer Center.

11 Dec 2017

Soy foods, cruciferous vegetables may reduce breast cancer treatment’s side effects

Consuming soy foods (such as soy milk, tofu and edamame) and cruciferous vegetables (such as cabbages, kale, collard greens, bok choy, Brussels sprouts, and broccoli) may be associated with a reduction in common side effects of breast cancer treatment in breast cancer survivors, say a team of scientists led by Georgetown Lombardi Comprehensive Cancer Center.

11 Dec 2017

Study estimates number of Americans with preclinical Alzheimer's or mild cognitive impairment

About 15 million Americans will have either Alzheimer's dementia or mild cognitive impairment by 2060, up from approximately 6.08 million this year, according to a new study by researchers at the UCLA Fielding School of Public Health.

8 Dec 2017

Researchers develop molecular beacon to find hypoxic spots in real time

Areas of hypoxia, or low oxygen in tissue, are hallmarks of fast-growing cancers and of blockages or narrowing in blood vessels, such as stroke or peripheral artery disease. University of Illinois researchers have developed a way to find hypoxic spots noninvasively in real time.

8 Dec 2017

IUPUI researchers receive $1.8 million grant to develop potential treatments for hydrocephalus

No drug treatment exists for hydrocephalus, the buildup of fluid known as "water on the brain" that can occur at any age.

8 Dec 2017

Immune-boosting drug combination may hold promise for treating ovarian cancer

Johns Hopkins Kimmel Cancer Center researchers demonstrated that mice with ovarian cancer that received drugs to reactivate dormant genes along with other drugs that activate the immune system had a greater reduction of tumor burden and significantly longer survival than those that received any of the drugs alone.

5 Dec 2017

DNA sequencing could identify genetic cause of kidney disease

DNA sequencing could soon become part of the routine diagnostic workup for patients with chronic kidney disease, suggests a new study from Columbia University Medical Center.

5 Dec 2017

New treatment aims to target abnormally shaped protein in deadly childhood brain cancer

Children with an extremely deadly form of brain cancer might benefit from a new treatment that aims to direct an immune response against an abnormally shaped protein found exclusively on cancer cells, according to a new study led by UC San Francisco researchers.

4 Dec 2017

New targeted treatment could benefit patients with certain pancreatic tumors

Researchers at the University of Cincinnati College of Medicine have shown that a new targeted treatment could benefit patients with certain pancreatic tumors by preventing spread of the cancer and protecting their heart from damage--a direct result of the tumor.

1 Dec 2017

UT Southwestern researchers develop improved gene-editing technique to correct DMD mutations

Regenerative medicine researchers at UT Southwestern Medical Center developed an improved and simplified gene-editing technique using CRISPR/Cas9 tools to correct a common mutation that causes Duchenne muscular dystrophy.

30 Nov 2017

Researchers tackling deadly TB discuss the way forward in treatment and prevention

Researchers from across the world who are tacking the deadly bacterial disease tuberculosis (TB) attended a symposium at St George's, University of London to discuss the way forward in treatment and prevention.

29 Nov 2017

Study reveals patients at high risk for opioid overdose deaths

Just over 60 percent of individuals who died from an opioid overdose had been diagnosed with a chronic pain condition, and many had been diagnosed with a psychiatric disorder, a study of more than 13,000 overdose deaths has found.

28 Nov 2017

New cancer drug begins clinical trial in human patients with rare brain tumor

A drug that spurs cancer cells to self-destruct has been cleared for use in a clinical trial of patients with anaplastic astrocytoma, a rare malignant brain tumor, and glioblastoma multiforme, an aggressive late-stage cancer of the brain.

28 Nov 2017

Researchers convert natural bacterial immune system into microscopic data recorder

Through a few clever molecular hacks, researchers at Columbia University Medical Center have converted a natural bacterial immune system into a microscopic data recorder, laying the groundwork for a new class of technologies that use bacterial cells for everything from disease diagnosis to environmental monitoring.

23 Nov 2017

Study uncovers key mechanism by which tumors develop resistance to radiation therapy

A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under development.

23 Nov 2017

New mechanism in cancer cells to disarm attacking immune cells, study reveals

A new study, published in the Journal of Clinical Investigation, identified a substance Gdf-15, which is secreted by pancreatic cancer cells and shields cancerous cells from attack by immune cells known as macrophages.

21 Nov 2017

Study identifies substance released by pancreatic cancer cells to disarm attacking macrophages

A new study by researchers at The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute identifies a substance released by pancreatic cancer cells that protect them from attack by immune cells called macrophages.

21 Nov 2017

Preclinical study shows clear path toward effective treatment for rare bone disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute have led a preclinical study demonstrating that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple hereditary exostoses (MHE).

20 Nov 2017

Researchers identify new way to reduce risk of complications after joint surgery

Researchers identified a new way to lower the risk of complications after joint surgery, using a simple blood test. Patients with diabetes are more likely to need joint replacement surgery but also have a greater risk of serious complications after surgery, including heart attack, stroke, and wound infections, because of their underlying diabetes.

16 Nov 2017

MGH researchers develop potential alternative to gadolinium-based MRI contrast agents

A team of Massachusetts General Hospital researchers has developed a potential alternative to gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging.

15 Nov 2017

Preclinical News and Research

Study: Combination targeted therapy has high response rates in AML patients

Soy foods, cruciferous vegetables may reduce breast cancer treatment’s side effects

Study estimates number of Americans with preclinical Alzheimer's or mild cognitive impairment

Researchers develop molecular beacon to find hypoxic spots in real time

IUPUI researchers receive $1.8 million grant to develop potential treatments for hydrocephalus

Immune-boosting drug combination may hold promise for treating ovarian cancer

DNA sequencing could identify genetic cause of kidney disease

New treatment aims to target abnormally shaped protein in deadly childhood brain cancer

New targeted treatment could benefit patients with certain pancreatic tumors

UT Southwestern researchers develop improved gene-editing technique to correct DMD mutations

Researchers tackling deadly TB discuss the way forward in treatment and prevention

Study reveals patients at high risk for opioid overdose deaths

New cancer drug begins clinical trial in human patients with rare brain tumor

Researchers convert natural bacterial immune system into microscopic data recorder

Study uncovers key mechanism by which tumors develop resistance to radiation therapy

New mechanism in cancer cells to disarm attacking immune cells, study reveals

Study identifies substance released by pancreatic cancer cells to disarm attacking macrophages

Preclinical study shows clear path toward effective treatment for rare bone disease

Researchers identify new way to reduce risk of complications after joint surgery

MGH researchers develop potential alternative to gadolinium-based MRI contrast agents

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