Antibody News and Research

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An antibody is a blood protein that is produced in response to and counteracts an antigen. Antibodies are produced in response to disease and help the body fight against the particular disease. In this way, antibodies help the body develop an immunity to disease.

MS patients receiving aCD20 treatment mount robust T-cell responses to COVID-19 vaccines

New research shows that Multiple Sclerosis (MS) patients undergoing anti-CD20 (aCD20) treatment – which depletes the B cells that contribute to the MS attacks – are able to mount robust T-cell responses to the mRNA COVID-19 vaccines, despite having a muted antibody response to the vaccines.

14 Sep 2021

Low dose of Moderna COVID-19 vaccine generates durable immune response

A new study from La Jolla Institute for Immunology (LJI) scientists helps answer the question: how long does immunity against COVID-19 last in vaccinated people?

14 Sep 2021

Study explains confounding effects of different dosages and dosing protocols on COVID-19 vaccine efficacies

A recent study investigates the paradoxical effects of dosage and dosing interval on COVID-19 vaccine efficacy.

14 Sep 2021

Severe COVID-19 linked to increase in autoantibodies

Hospitalized COVID-19 patients are substantially more likely to harbor autoantibodies - antibodies directed at their own tissues or at substances their immune cells secrete into the blood - than people without COVID-19, according to a new study.

14 Sep 2021

mRNA BNT162b2 vaccine safe in immunocompromised patients

The clinical trial showed that about 72.2% of immunocompromised patients had detectable antibodies against SARS-CoV-2.

14 Sep 2021

Convalescent plasma shows no benefit in hospitalized COVID-19 patients

A new paper describes the results of a randomized controlled trial of CP in adult COVID-19 patients on oxygen when used within 12 days of the onset of respiratory symptoms.

14 Sep 2021

Impact of prior SARS-CoV-2 infection and vaccine on antibody levels: Texas survey

A collaborative team, led by principal investigator Dr. Eric Boerwinkle, at The University of Texas Health Science Center at Houston, School of Public Health is conducting a survey designed to assess the frequency of antibody-positive individuals across Texas. The TEXAS Coronavirus Antibody REsponse Survey (CARES) aims to look for antibodies in the blood made in response to natural SARS-CoV-2 infection or vaccination.

14 Sep 2021

A review of mesenchymal stem cell therapy for severe COVID-19

Researchers find that MSC treatment is highly tolerated and effective in reducing lung damage in COVID-19 patients and improving their chances of recovery.

13 Sep 2021

Artemisia plant extract prevents SARS-CoV-2 replication in vitro

A new study describes the beneficial effect of an extract of Artemisia annua when used to treat cells in culture exposed to SARS-CoV-2.

13 Sep 2021

Study identifies broadly neutralizing antibody panel against SARS-like viruses

A recent study describes 40 broadly neutralizing antibodies from two individuals with a history of COVID-19 who were recently immunized against the virus.

13 Sep 2021

Efficient non-neutralizing antibody to SARS-CoV-2 spike NTD that operates via Fc receptor-mediated pathway

This study revealed that the CV3-13 antibody can mediate Fc effector functions against S protein-expressing cells.

13 Sep 2021

Research supports COVID booster vaccines for those aged 60 and over

Israeli researchers conducted an important study to determine if the Pfizer-BioNTech BNT162b2 vaccine had become less effective in preventing infection.

13 Sep 2021

Newly developed antibody may be used to treat muscular dystrophy

Northwestern Medicine scientists have developed an antibody that they believe can be used to treat muscular dystrophy, findings that were published in Science Translational Medicine.

13 Sep 2021

The comparative effectiveness of neutralizing monoclonal antibodies against SARS-CoV-2

A study investigated the comparative efficacy of neutralizing monoclonal antibodies against SARS-CoV-2.

13 Sep 2021

An oral COVID-19 vaccine induces mucosal and protective immunity

Researchers have collaborated to resolve the aforementioned problems associated with injection vaccines to create a thermostable vaccine that can be taken orally.

13 Sep 2021

Discovery of diverse sarbecovirus broadly neutralizing antibodies from SARS-CoV-2 “infected-vaccinated” humans

Scientists were inspired by the robust serum nAb responses in people who recovered from natural SARS-CoV-2 infection and were later vaccinated using mRNA vaccine. They isolated and characterized bnAbs from two COVID-19 convalescent donors who were recently vaccinated. These isolated bnAbs were found to be highly potent against sarbecoviruses. This research is available on the bioRxiv* preprint server.

13 Sep 2021

Scientists develop a novel and potent SARS-CoV-2 RBD-homodimer vaccine

A recent report published in the journal Cell Discovery has described the immunogenicity and protective efficacy of a novel coronavirus disease 2019 (COVID-19) subunit vaccine candidate. The vaccine induces robust immune responses in rodents and non-human primates and protects the animals against severe disease.

12 Sep 2021

The strengths and weaknesses of the spike protein in SARS-CoV-2 variants

The S protein has the ability to appropriate various conformations that are dependent on the formation of the receptor-binding domain (RBD) of its protomers.

12 Sep 2021

Brown researchers receive $4.9 million to study COVID-19 vaccine effectiveness in older adults

To address the pressing issue of diminishing immunity among older adults to COVID-19 as well to vaccines designed to protect against the virus, a $4.9 million award from the U.S. Centers for Disease Control and Prevention will fund a two-year project led by Brown University researchers and conducted by a team spanning multiple institutions.

10 Sep 2021

Convalescent plasma does not reduce risk of intubation or death for COVID-19 hospitalized patients

A major study has found that convalescent plasma does not reduce the risk of intubation or death for COVID-19 patients.

10 Sep 2021

Antibody News and Research

Further Reading

MS patients receiving aCD20 treatment mount robust T-cell responses to COVID-19 vaccines

Low dose of Moderna COVID-19 vaccine generates durable immune response

Study explains confounding effects of different dosages and dosing protocols on COVID-19 vaccine efficacies

Severe COVID-19 linked to increase in autoantibodies

mRNA BNT162b2 vaccine safe in immunocompromised patients

Convalescent plasma shows no benefit in hospitalized COVID-19 patients

Impact of prior SARS-CoV-2 infection and vaccine on antibody levels: Texas survey

A review of mesenchymal stem cell therapy for severe COVID-19

Artemisia plant extract prevents SARS-CoV-2 replication in vitro

Study identifies broadly neutralizing antibody panel against SARS-like viruses

Efficient non-neutralizing antibody to SARS-CoV-2 spike NTD that operates via Fc receptor-mediated pathway

Research supports COVID booster vaccines for those aged 60 and over

Newly developed antibody may be used to treat muscular dystrophy

The comparative effectiveness of neutralizing monoclonal antibodies against SARS-CoV-2

An oral COVID-19 vaccine induces mucosal and protective immunity

Discovery of diverse sarbecovirus broadly neutralizing antibodies from SARS-CoV-2 “infected-vaccinated” humans

Scientists develop a novel and potent SARS-CoV-2 RBD-homodimer vaccine

The strengths and weaknesses of the spike protein in SARS-CoV-2 variants

Brown researchers receive $4.9 million to study COVID-19 vaccine effectiveness in older adults

Convalescent plasma does not reduce risk of intubation or death for COVID-19 hospitalized patients

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