Biomarker News and Research

RSS

A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Researchers examine molecular profile of HPV-positive oropharyngeal squamous cell carcinoma

Throat cancer patients exposed to both human papillomavirus (HPV) and tobacco smoke demonstrate a pattern of mutations along several key cancer genes, according to research presented today at the 2016 Multidisciplinary Head and Neck Cancer Symposium.

19 Feb 2016

Post-treatment imaging can help detect recurrences of HPV-positive oropharyngeal cancer

For patients treated with definitive radiation therapy (RT) for oropharyngeal cancer caused by human papillomavirus (HPV), the majority of recurrences can be detected by post-treatment imaging at three months and physical exams during the six months following treatment, according to research presented at the 2016 Multidisciplinary Head and Neck Cancer Symposium.

19 Feb 2016

Uninsured and Medicaid patients have higher overall and cancer-specific mortality rates

Compared to patients with non-Medicaid insurance, uninsured patients and patients with Medicaid are more likely to present with advanced stages of head and neck cancer and have higher overall and cancer-specific mortality rates, according to research presented at the 2016 Multidisciplinary Head and Neck Cancer Symposium.

19 Feb 2016

Chemoradiation improves survival rates among subset of elderly head and neck cancer patients

The addition of chemotherapy (CT) to radiation therapy (RT) improves survival rates among a subset of elderly head and neck cancer patients, specifically those ages 71 to 79 with low comorbidity scores and advanced disease stage, according to research presented at the 2016 Multidisciplinary Head and Neck Cancer Symposium.

19 Feb 2016

DEK gene present in plasma can help predict outcomes for patients with head and neck cancer

Researchers at the University of Cincinnati have discovered that a human cancer-causing gene, called DEK, can be detected in the plasma of head and neck cancer patients. DEK may help doctors understand how a person's immune system could be used to treat cancer or predict outcomes for patients.

18 Feb 2016

Study explores link between CSF biomarkers and cognition in Parkinson's disease

Many patients with Parkinson's Disease (PD) develop mild cognitive impairment (MCI) or dementia. Identifying biomarkers for cognitive impairment could be instrumental in facilitating both early diagnosis of MCI and developing new cognitive-enhancing treatments. New research published in the Journal of Parkinson's Disease indicates that lower concentrations of α-synuclein in cerebrospinal fluid (CSF) is associated with reduced performance on several cognitive tests.

18 Feb 2016

Apogenix awarded €3 million grant to develop immuno-oncology candidate APG101 as personalized therapy

Apogenix, a biopharmaceutical company developing next generation immuno-oncology therapeutics, announced today that it has received funding approval in the amount of €3 million from the German Federal Ministry of Education and Research for the so-called CancerMark project.

16 Feb 2016

Novel test could help get best treatment for advanced bowel cancer patients

A NEW test could help patients with advanced bowel cancer get the best treatment for their disease, according to a Cancer Research UK clinical trial published today (Thursday) in JAMA Oncology.

11 Feb 2016

Cancer patients who miss scheduled radiation therapy appointments have worse outcomes

Cancer patients who miss two or more radiation therapy sessions have a worse outcome than fully compliant patients, investigators at Montefiore Einstein Center for Cancer Care and Albert Einstein College of Medicine's NCI-designated Albert Einstein Cancer Center have found.

10 Feb 2016

UC San Diego School of Medicine launches new NAFLD Research Center

Roughly one-quarter of all Americans - an estimated 100 million adults and children - have nonalcoholic fatty liver disease (NAFLD), a chronic condition that can lead to cirrhosis, liver cancer and liver failure.

9 Feb 2016

New discovery takes medical professionals a leap forward to effectively diagnose Alzheimer's disease

Medical professionals have to conduct a long series of tests to assess a patient's memory impairment and cognitive skills, functional abilities, and behavioral changes to accurately diagnose Alzheimer's disease. They also have to execute costly brain imagining scans and even, sometimes, invasive cerebral spinal fluid tests to rule out other diseases. The process is laborious at best -- and subjective at worst.

9 Feb 2016

New biosensing platform could help determine Haptoglobin in human blood

We are pleased to announce that a new biosensing platform has been fabricated for the determination of Haptoglobin in human blood.

9 Feb 2016

Study reveals association between DNA methylation and type 2 diabetes

Researchers from the Hospital del Mar Medical Research Institute have found an epigenetic mechanism implicated in the regulation of blood sugar. The study, published in the journal Molecular Human Genetics, reveals that the methylation of the TXNIP gene is associated with diabetes mellitus type 2 and, in particular, average blood glucose levels.

8 Feb 2016

University of Oxford, SomaLogic partner to discover protein biomarkers for clinical diseases and conditions

The University of Oxford and SomaLogic announced today that they have agreed to undertake a number of collaborative projects that will employ SomaLogic's proprietary SOMAmer reagents and SOMAscan assay technologies to discover and characterize protein biomarkers for a range of clinical diseases and conditions.

8 Feb 2016

New personalized DNA-based digital assay has potential to dramatically impact CML management

The outcomes of chronic myeloid leukemia (CML) have dramatically improved as the result of tyrosine kinase inhibitor (TKI) treatment. Use of a TKI regimen can lower the blood CML biomarker to levels imperceptible by current detection methods. For patients in "molecular remission," however, uncertainties remain regarding whether they will relapse or if treatment should be discontinued.

8 Feb 2016

Scientists identify potential marker for recurring HPV-positive oropharyngeal cancer

A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at The Johns Hopkins University.

7 Feb 2016

VolitionRx initiates study to assess NuQ blood tests for detection of prostate cancer

VolitionRx Limited today announced that it has initiated a study to assess the feasibility of using the Company’s NuQ blood tests to detect prostate cancer. The study is in collaboration with the Surrey Cancer Research Institute of the University of Surrey in the UK.

5 Feb 2016

Study provides window into the brain changes that link mindfulness meditation with health-related benefits

Over the past decade, mindfulness meditation has been shown to improve a broad range of health and disease outcomes, such as slowing HIV progression and improving healthy aging. Yet, little is known about the brain changes that produce these beneficial health effects.

5 Feb 2016

Duke scientists reveal how gut inflammation increases colon cancer risk

Chronic inflammation in the gut increases the risk of colon cancer by as much as 500 percent, and now Duke University researchers think they know why.

5 Feb 2016

BDNF gene expression signals cognitive reserve against AD progression

Brain-derived neurotrophic factor gene expression contributes to slowing of cognitive decline in older adults and may protect against the effects of Alzheimer’s disease pathology, researchers report in Neurology.

4 Feb 2016

Biomarker News and Research

Further Reading

Researchers examine molecular profile of HPV-positive oropharyngeal squamous cell carcinoma

Post-treatment imaging can help detect recurrences of HPV-positive oropharyngeal cancer

Uninsured and Medicaid patients have higher overall and cancer-specific mortality rates

Chemoradiation improves survival rates among subset of elderly head and neck cancer patients

DEK gene present in plasma can help predict outcomes for patients with head and neck cancer

Study explores link between CSF biomarkers and cognition in Parkinson's disease

Apogenix awarded €3 million grant to develop immuno-oncology candidate APG101 as personalized therapy

Novel test could help get best treatment for advanced bowel cancer patients

Cancer patients who miss scheduled radiation therapy appointments have worse outcomes

UC San Diego School of Medicine launches new NAFLD Research Center

New discovery takes medical professionals a leap forward to effectively diagnose Alzheimer's disease

New biosensing platform could help determine Haptoglobin in human blood

Study reveals association between DNA methylation and type 2 diabetes

University of Oxford, SomaLogic partner to discover protein biomarkers for clinical diseases and conditions

New personalized DNA-based digital assay has potential to dramatically impact CML management

Scientists identify potential marker for recurring HPV-positive oropharyngeal cancer

VolitionRx initiates study to assess NuQ blood tests for detection of prostate cancer

Study provides window into the brain changes that link mindfulness meditation with health-related benefits

Duke scientists reveal how gut inflammation increases colon cancer risk

BDNF gene expression signals cognitive reserve against AD progression

Event guide: 16th Clinical Biomarkers & CDx Summit Europe eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo