Efficacy News and Research

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Researchers receive PCORI funding to study the effectiveness of individualized model of hemodialysis

The Patient-Centered Outcomes Research Institute (PCORI) recently awarded researchers at Wake Forest University School of Medicine $10.2 million to study the effectiveness of an individualized model of hemodialysis, a procedure in which the blood is cleaned by a dialysis machine.

9 Mar 2023

Healthy gut bacteria can travel to other parts of the body and boost antitumor immunity

Researchers at UT Southwestern Medical Center have discovered how healthy bacteria can escape the intestine, travel to lymph nodes and cancerous tumors elsewhere in the body, and boost the effectiveness of certain immunotherapy drugs.

9 Mar 2023

New class of oral drugs can inhibit a diverse range of pathogenic SARS-CoV-2 strains

The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections.

9 Mar 2023

Are self-sanitizing disinfectants containing quaternary ammonium compounds truly effective against respiratory viruses?

Researchers evaluated the antimicrobial efficiency of two commercially available disinfectants containing quaternary ammonium compounds against influenza A virus (hemagglutinin 1 neuraminidase 1 (H1N1)), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and human coronavirus 229E.

9 Mar 2023

Early outpatient treatment of COVID-19 with metformin could reduce the risk of developing long COVID

In a recent study posted to Preprints with The Lancet*, a team of researchers from the United States investigated whether early outpatient treatment of coronavirus disease 2019 (COVID-19) patients with fluvoxamine, ivermectin, or metformin could prevent long coronavirus disease (long COVID).

9 Mar 2023

Evaluating SARS-CoV-2 bivalent booster vaccine against severe COVID-19 outcomes

In a recent study posted to the medRxiv* preprint server, researchers assessed the effectiveness of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) bivalent booster vaccine against severe SARS-CoV-2 infection outcomes.

9 Mar 2023

Early safety and efficacy results on a contraceptive vaginal film that inactivates sperm

The current study aimed to explore the contraceptive potential of the human contraceptive antibody-containing vaginal film called ZB-06.

7 Mar 2023

100% vaccination rate could have prevented half of COVID-19 deaths in the U.S.

Scientists in the United States have conducted a simulation study to estimate the number of coronavirus disease 2019 (COVID-19) deaths that could have been prevented by increasing vaccination coverage in the country.

7 Mar 2023

First-in-woman study of a non-hormonal vaginal film showed safety, potential contraceptive efficacy, and supports future development

Researchers developed a novel contraceptive 'ZB-06' a vaginal film containing a human contraceptive antibody called HC4-N that agglutinates sperm.

7 Mar 2023

CDC recommendations and clinical considerations for the treatment of severe Mpox

In a recent article published in the United States (U.S.) Centers for Disease Control and Prevention's (CDC) Morbidity and Mortality Weekly Report, a team of researchers discussed the medical countermeasures and clinical considerations for treating severe manifestations of Mpox.

6 Mar 2023

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

Researchers evaluate the response of pre-existing immunity to booster doses of mRNA COVID-19 vaccines.

6 Mar 2023

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation.

6 Mar 2023

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

It may come as a surprise, but bacteria love to grow inside tumors. It's the environment - tumors are typically acidic, have low amounts of oxygen, and are filled with dead cells, which all facilitate bacterial growth.

6 Mar 2023

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

MK-0616, an experimental oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, met its primary endpoint and substantially reduced levels of low-density lipoprotein (LDL) cholesterol in people with high cholesterol and/or heart disease related to clogged arteries, in a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension (PAH), a severe, progressive condition that affects the heart and lungs, who were treated with the novel first-in-class medication sotatercept on top of existing therapy experienced significant improvements in walking distance via a six-minute walking test—the study's primary endpoint and a validated surrogate for functional improvement and reduced symptom burden.

6 Mar 2023

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system.

6 Mar 2023

New ablation technology successful at eliminating episodes of abnormal heart rhythms

A new ablation technology known as pulsed-field ablation was successful at eliminating episodes of abnormal heart rhythms for 12 months in up to two-thirds of patients, according to a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Efficacy News and Research

Researchers receive PCORI funding to study the effectiveness of individualized model of hemodialysis

Healthy gut bacteria can travel to other parts of the body and boost antitumor immunity

New class of oral drugs can inhibit a diverse range of pathogenic SARS-CoV-2 strains

Are self-sanitizing disinfectants containing quaternary ammonium compounds truly effective against respiratory viruses?

Early outpatient treatment of COVID-19 with metformin could reduce the risk of developing long COVID

Evaluating SARS-CoV-2 bivalent booster vaccine against severe COVID-19 outcomes

Early safety and efficacy results on a contraceptive vaginal film that inactivates sperm

100% vaccination rate could have prevented half of COVID-19 deaths in the U.S.

First-in-woman study of a non-hormonal vaginal film showed safety, potential contraceptive efficacy, and supports future development

CDC recommendations and clinical considerations for the treatment of severe Mpox

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

LDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

New ablation technology successful at eliminating episodes of abnormal heart rhythms

What is the impact of oral cannabidiol on simulated driving?

Trial emulation shows the effectiveness of the COVID-19 vaccine in improving long COVID symptoms

Meta-analysis on COVID-19 vaccine effectiveness in association with antibody titers

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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