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Evolutionary snapshot reveals genetic stability of SARS-CoV-2

A multinational study currently available on the bioRxiv preprint server shows that in the early large genome of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) only a handful of amino acids are exchanged, implying a relatively low mutation rate and selection pressure.

7 Jul 2020

New web-based tool could contribute to the development of better cancer treatments

The results are now published in Nature Medicine and at the same time the tool - the Molecular Tumor Board Portal - will be launched on www.mtbp.org. Janne Lehtiö, professor at the Karolinska Institutet Department of Oncology-Pathology led this work, along with researcher David Tamborero.

7 Jul 2020

Study: Group genomics are responsible for aggression in Africanized honey bees

Researchers often study the genomes of individual organisms to try to tease out the relationship between genes and behavior.

7 Jul 2020

SARS-CoV-2 detected in Santiago, Chile wastewater with very little loss of viral RNA

A preliminary report from Chile describes the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in sewage as a sensitive method to assess the circulation of viruses within a community.

7 Jul 2020

NPHS1 is a disease-susceptibility gene for steroid-sensitive nephrotic syndrome, reveals study

An international research collaboration, including Professor IIJIMA Kazumoto et al. (of the Department of Pediatrics, Kobe University Graduate School of Medicine) has revealed that NPHS1 is a disease-susceptibility gene for steroid-sensitive nephrotic syndrome in children.

3 Jul 2020

Structure of the full SARS-CoV-2 RNA genome in infected cells

The current COVID-19 pandemic caused by a single-stranded RNA virus, thought to have jumped across species barriers to infect humans, has spread rapidly across the globe infecting over 10 million individuals. The virus, now known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the causative agent of COVID-19 disease. COVID-19 disease is a respiratory illness where symptoms can range from very mild to severe and include fever, coughing, a sore throat, and shortness of breath.

2 Jul 2020

NIH announces $75 million in funding to improve genomic risk assessments for diverse populations

The National Institutes of Health has announced the provision of $75 million in funding over five years for the Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network, which establish protocols and methodologies for improved genomic risk assessments for diverse populations and to integrate their use in clinical care.

1 Jul 2020

CHOP researchers receive multi-million dollar grant to study disease risk in African Americans

The National Institutes of Health announced today that researchers from Children's Hospital of Philadelphia are among the recipients of a multi-million dollar grant that focuses on the use of genomics to improve risk assessment for diverse populations and integrate the findings into clinical care.

1 Jul 2020

Researchers to receive Real-World Data Impact Award to advance patient-centric research

Three American Cancer Society researchers will receive the Real-World Data Impact Award to advance patient-centric research, the ACS and Flatiron Health announced today.

1 Jul 2020

Researchers develop technique for personalizing stomach cancer therapy

Researchers from the Moscow Institute of Physics and Technology and their colleagues have developed the first technique for personalizing stomach cancer therapy based on RNA sequencing of tumor cells. The study, supported by the Russian Science Foundation, was published in Cold Spring Harbor Molecular Case Studies.

30 Jun 2020

Specific SARS-CoV-2 genetic elements found in different insect species

In a recent bioRxiv paper, researchers from Norway and the US demonstrate the presence of a highly conserved, mobile genetic element (thus far with unknown function) in genomes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a large number of insects – opening the door for hitherto unexplored treatment opportunities.

30 Jun 2020

A data-rich atlas of the developing human brain

For the nascent brain of a human embryo to develop into the complex organ that controls human consciousness, a finely tuned sequence of genetic events has to take place; hundreds of genes are activated and deactivated in a precise symphony.

30 Jun 2020

Genomic sequencing to provide precision medicine for aromatase deficiency

An international team of scientists from Switzerland Spain, has studied the genetic basis of aromatase deficiency, a rare metabolic disorder that prevents the production of estrogens in humans, according to new research in JCEM.

30 Jun 2020

GHGA to address need for access to genomic and phenomic data

In Germany, there is currently a lack of infrastructure to deal with high-volume biological and biomedical data, such as data found in medical records.

30 Jun 2020

Spike protein and human ACE2 binding ability shows SARS-CoV-2 viral adaptation

A new study published on the preprint server bioRxiv in June 2020 reports some important findings that could shed light on this question. As the pandemic marches on, having claimed over 500,000 lives and caused well over 10 million infections to date, the task of defining and predicting factors that predispose to infectivity across species becomes ever more critical.

30 Jun 2020

Engineered immune cells attack solid-tumor cancer cells from humans and mice

A method known as CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia.

30 Jun 2020

SARS-CoV-2 circulating in Italy in December 2019

Researchers at the Istituto Superiore di Sanità (Italian National Institute of Health) have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had already been circulating in Italy many weeks before the first autochthonous (native) case was documented on February 21st this year.

29 Jun 2020

Researchers show how upregulation of a single gene by SARs-CoV-2 can trigger cytokine storm

The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs).

29 Jun 2020

Genomics used to trace origin of SARS-CoV-2 in Canada

A new study published in June 2020 on the preprint server bioRxiv discusses the use of phylogenetic analysis to trace the origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and its spread into and then within Canada. The study findings may help optimize public health policies in the case of future outbreaks.

28 Jun 2020

Study identifies small molecule inhibitors of SARS-CoV-2 which block key cellular kinases

Antiviral drug screen of kinase inhibitors, which was done by researchers from the University of California and Cedars-Sinai Medical Center, identified cellular signaling pathways critical for SARS-CoV-2 replication and revealed an important mechanism of host-pathogen interaction vital for further drug research. Their results are available on the bioRxiv* preprint server.

28 Jun 2020

Genomic News and Research

Evolutionary snapshot reveals genetic stability of SARS-CoV-2

New web-based tool could contribute to the development of better cancer treatments

Study: Group genomics are responsible for aggression in Africanized honey bees

SARS-CoV-2 detected in Santiago, Chile wastewater with very little loss of viral RNA

NPHS1 is a disease-susceptibility gene for steroid-sensitive nephrotic syndrome, reveals study

Structure of the full SARS-CoV-2 RNA genome in infected cells

NIH announces $75 million in funding to improve genomic risk assessments for diverse populations

CHOP researchers receive multi-million dollar grant to study disease risk in African Americans

Researchers to receive Real-World Data Impact Award to advance patient-centric research

Researchers develop technique for personalizing stomach cancer therapy

Specific SARS-CoV-2 genetic elements found in different insect species

A data-rich atlas of the developing human brain

Genomic sequencing to provide precision medicine for aromatase deficiency

GHGA to address need for access to genomic and phenomic data

Spike protein and human ACE2 binding ability shows SARS-CoV-2 viral adaptation

Engineered immune cells attack solid-tumor cancer cells from humans and mice

SARS-CoV-2 circulating in Italy in December 2019

Researchers show how upregulation of a single gene by SARs-CoV-2 can trigger cytokine storm

Genomics used to trace origin of SARS-CoV-2 in Canada

Study identifies small molecule inhibitors of SARS-CoV-2 which block key cellular kinases

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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