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Omicron variant of SARS-CoV-2 leads to less severe disease in mouse models

Georgia State University researchers have found that the Alpha, Beta and Delta variants of SARS-CoV-2 were substantially more fatal in mouse models than the original strain of the virus that causes COVID-19.

27 Jun 2022

Lipid-peptide nanocomplexes offer new mRNA platform

A new paper reports the methodical development of lipid-peptide nanocomplexes as a delivery vehicle for messenger ribonucleic acid molecules to the tumor cell, in vitro and in vivo.

27 Jun 2022

Scientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parameters

Scientists conducted a meta-analysis to study the impacts of COVID-19 on the male reproductive system.

27 Jun 2022

Breakthrough infection with pre-Omicron variant induces cross-neutralizing activity against Omicron

Researchers evaluated the neutralizing ability of sera from COVID-19 patients.

27 Jun 2022

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Researchers constructed a full-length SARS-CoV-2 spike structure in its membrane-bound state to study functionally relevant aspects of its global conformational dynamics.

27 Jun 2022

Study investigates the virological attributes of Omicron in a Syrian hamster model

Researchers investigated the virological attributes of SARS‐CoV‐2 new variant of concern Omicron in a Syrian hamster model.

27 Jun 2022

Antibody profiles of internal viral proteins predict severe COVID-19 outcomes

Most research on immunity to the SARS-CoV-2 virus and COVID-19 vaccine development has focused on antibody responses to the spike protein and other viral surface proteins.

24 Jun 2022

Inhibiting pore formation in cells may facilitate prevention, treatment of NASH-associated liver cancer

Need another reason to think twice before ordering that extra helping of fries? It could lead to a higher risk of developing liver cancer.

24 Jun 2022

Study uncovers cryptic vulnerabilities in RET oncogene that could aid in anti-cancer drug design

RET is a receptor protein with tyrosine kinase activity that can transfer a phosphate group from ATP to other molecules modifying their shape and function in signaling pathways that are essential to organogenesis and tissue maintenance.

24 Jun 2022

Scientists identify new genetic disease that delays children's intellectual development

Scientists have identified a new genetic disease, which causes some children's brains to develop abnormally, resulting in delayed intellectual development.

24 Jun 2022

Scientists develop suitable human cell line for anti-SARS-CoV-2 drug screening

Scientists have described the development of a modified A549 cell line that shows a robust expression of ACE2 and TMPRSS2 and high susceptibility to SARS-CoV-2 infection.

24 Jun 2022

Natural and hybrid immunity dynamics in South African mothers

Researchers evaluated natural and hybrid immunity after four COVID-19 waves in South Africa.

24 Jun 2022

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

In a recent study posted to the medRxiv* pre-print server, researchers in the United States characterized differential host immune responses in acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) to inform future development of novel biomarkers for both diseases.

23 Jun 2022

Mild COVID causes increase in neurotoxic metabolites

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the blood levels of neurotoxic metabolites in patients with mild coronavirus disease 2019 (COVID-19).

23 Jun 2022

Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models

A recent article posted to the bioRxiv* preprint server identified numerous efficacious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from convalescent SARS-CoV-2 patients.

23 Jun 2022

Inherited mutations in the MINAR2 gene lead to sensorineural deafness

Researchers at the John T. Macdonald Department of Human Genetics and John P. Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine have found that inherited mutations in the MINAR2 gene caused deafness in four families.

23 Jun 2022

Kratom: A dangerous or beneficial plant?

A new study summarizes the traditional and modern uses of kratom, as well as its pharmacology, benefits, and adverse health impacts.

23 Jun 2022

Midgestation increase in leptin puts child and mother at risk of cardiovascular disease

Before a baby is ever born, critical supply chain problems with nutrition and oxygen can result in premature birth or even death and increase the child and mother's lifelong risk of cardiovascular disease.

23 Jun 2022

Correlates of anamnestic humoral immunity throughout SARS-CoV-2 variants of concern

A recent work posted to the bioRxiv* preprint server assessed the indicators of anamnestic humoral immunity among the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs).

23 Jun 2022

Analyzing biophysical restrictions of SARS-CoV-2 N-terminal domain

In a recent article posted to the bioRxiv* preprint server, researchers at the University of Illinois at Urbana-Champaign, Scripps Research Institute, and Case Western Reserve University evaluated the biophysical limitations of the spike (S) N-terminal domain (NTD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

23 Jun 2022

Receptor News and Research

Omicron variant of SARS-CoV-2 leads to less severe disease in mouse models

Lipid-peptide nanocomplexes offer new mRNA platform

Scientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parameters

Breakthrough infection with pre-Omicron variant induces cross-neutralizing activity against Omicron

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Study investigates the virological attributes of Omicron in a Syrian hamster model

Antibody profiles of internal viral proteins predict severe COVID-19 outcomes

Inhibiting pore formation in cells may facilitate prevention, treatment of NASH-associated liver cancer

Study uncovers cryptic vulnerabilities in RET oncogene that could aid in anti-cancer drug design

Scientists identify new genetic disease that delays children's intellectual development

Scientists develop suitable human cell line for anti-SARS-CoV-2 drug screening

Natural and hybrid immunity dynamics in South African mothers

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

Mild COVID causes increase in neurotoxic metabolites

Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models

Inherited mutations in the MINAR2 gene lead to sensorineural deafness

Kratom: A dangerous or beneficial plant?

Midgestation increase in leptin puts child and mother at risk of cardiovascular disease

Correlates of anamnestic humoral immunity throughout SARS-CoV-2 variants of concern

Analyzing biophysical restrictions of SARS-CoV-2 N-terminal domain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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