Clinical Trial News and Research

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New tool can help researchers interpret the clinical significance of somatic mutations in cancer

Researchers at Children's Hospital of Philadelphia have developed a new tool to help researchers interpret the clinical significance of somatic mutations in cancer.

6 May 2022

Mailed at-home disposal kits increase disposal rates of unused opioids after surgery

Mailed opioid disposal kits led to 60 percent of patients who had leftover opioid pain pills properly disposing of them after surgeries, according to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania.

6 May 2022

Social media break could lead to significant improvements in wellbeing

Asking people to stop using social media for just one week could lead to significant improvements in their wellbeing, depression and anxiety and could, in the future, be recommended as a way to help people manage their mental health say the authors of a new study.

6 May 2022

Study finds promising new treatment for patients with behavioral variant frontotemporal dementia

A Monash University led study has found a promising new treatment for patients with behavioural variant frontotemporal dementia, the second most common form of dementia in the under 60s – resulting in a stabilising of what would normally be escalating behavioural issues, and a slowing of brain shrinkage due to the disease.

6 May 2022

NIH launches clinical study to evaluate an investigational preventative vaccine for Epstein-Barr virus

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched an early-stage clinical trial to evaluate an investigational preventative vaccine for Epstein-Barr virus (EBV).

6 May 2022

Insight into Neurological Diagnosis in Children

In this interview, we speak to Amy Brin, MSN, MA, PCNS-BC, CEO of the Child Neurology Foundation, about the current landscape of neurological diagnosis in children and the importance of helping patients and their families through the diagnosis and treatment process.

6 May 2022

KHN’s ‘What the Health?’: Leaked abortion opinion rocks Washington’s world

People who pay attention to the Supreme Court have been expecting the justices to scale back the right to abortion when they issue their ruling on a Mississippi abortion law by the end of the current session.

5 May 2022

Evaluating the findings of phase 3 clinical trial of plant-based COVID-19 vaccine

A new study has presented the safety and efficacy profiles of a plant-based adjuvanted coronavirus disease 2019 (COVID-19) vaccine in human participants.

5 May 2022

Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

It's not often that a failed clinical trial leads to a scientific breakthrough. When patients in the UK started showing adverse side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back through the data and worked with patient samples to see what went wrong.

5 May 2022

Study assesses the efficacy and safety of lithium treatment in patients infected with severe SARS-CoV-2

Researchers assessed the efficacy and safety of using lithium for coronavirus disease 2019 (COVID-19) treatment.

5 May 2022

Study supports daily steroid doses for children with Duchenne muscular dystrophy

New research published in JAMA recommends daily steroid doses for children with Duchenne muscular dystrophy (DMD), marking a significant change in how the disease is treated.

4 May 2022

Phase 2 clinical trial of COVID-19 convalescent plasma with high antibody titers

Researchers determined the threshold neutralizing antibody titer for effective COVID-19 convalescent plasma therapy.

4 May 2022

Researchers reveal the mechanism of action of century-old BCG vaccine

The century-old Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is one of the world's oldest and most widely used vaccines, used to immunize 100 million newborns every year. Given in countries with endemic TB, it has surprisingly been found to protect newborns and young infants against multiple bacterial and viral infections unrelated to TB. There's even some evidence that it can reduce severity of COVID-19.

4 May 2022

Two specific brain networks can strongly influence weight-loss success

When it comes to weight loss, the old adage it's all in your head may be true.

4 May 2022

Novel magnetic therapy complements chemotherapy to enhance breast cancer treatment outcomes

Breast cancer is the leading cause of cancer-associated death for women worldwide. While chemotherapy is the mainstream treatment for breast cancer, more than 50% of women undergoing chemotherapy will experience at least one chemotherapy-related adverse side effect.

3 May 2022

Trial shows the efficacy of anti-TNF drug for patients with early-stage Dupuytren's disease

Researchers at the Kennedy Institute, University of Oxford, led by Professor Jagdeep Nanchahal have demonstrated the efficacy of the anti-TNF drug adalimumab for patients with early-stage Dupuytren's disease.

30 Apr 2022

Weill Cornell Medicine honors students, staff for exemplary efforts to promote diversity and inclusion

Weill Cornell Medicine honored a dozen faculty, trainees, students and staff April 25 for their outstanding service and leadership in promoting diversity at the academic medical institution.

29 Apr 2022

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

In a recent randomized clinical trial of hospitalized patients with COVID-19 and cardio-metabolic risk factors, the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin did not significantly reduce patients' risk of organ failure, kidney problems, or death compared with placebo, although numerically fewer participants treated with dapagliflozin experienced these outcomes. The findings are published in CJASN.

29 Apr 2022

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

A recent study published in the journal Immunology analyzed whether sex mattered in the immune response to SARS-CoV-2.

29 Apr 2022

Black and Hispanic people get the same benefits from CAR-T therapy as white patients

CAR-T therapy, a form of immunotherapy that revs up T-cells to recognize and destroy cancer cells, has revolutionized the treatment of blood cancers, including certain leukemias, lymphomas, and most recently, multiple myeloma.

28 Apr 2022

Clinical Trial News and Research

New tool can help researchers interpret the clinical significance of somatic mutations in cancer

Mailed at-home disposal kits increase disposal rates of unused opioids after surgery

Social media break could lead to significant improvements in wellbeing

Study finds promising new treatment for patients with behavioral variant frontotemporal dementia

NIH launches clinical study to evaluate an investigational preventative vaccine for Epstein-Barr virus

Insight into Neurological Diagnosis in Children

KHN’s ‘What the Health?’: Leaked abortion opinion rocks Washington’s world

Evaluating the findings of phase 3 clinical trial of plant-based COVID-19 vaccine

Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

Study assesses the efficacy and safety of lithium treatment in patients infected with severe SARS-CoV-2

Study supports daily steroid doses for children with Duchenne muscular dystrophy

Phase 2 clinical trial of COVID-19 convalescent plasma with high antibody titers

Researchers reveal the mechanism of action of century-old BCG vaccine

Two specific brain networks can strongly influence weight-loss success

Novel magnetic therapy complements chemotherapy to enhance breast cancer treatment outcomes

Trial shows the efficacy of anti-TNF drug for patients with early-stage Dupuytren's disease

Weill Cornell Medicine honors students, staff for exemplary efforts to promote diversity and inclusion

Dapagliflozin did not reduce risks in patients hospitalized with COVID-19

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

Black and Hispanic people get the same benefits from CAR-T therapy as white patients

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