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Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials

The importance of computational modeling in the prediction of the course of the ongoing COVID-19 pandemic, as well as evaluating multiple potential drug leads, has never been more clear. Now, a new study describes a set of designer vaccine antigens that may improve vaccine stability as well as enhance the neutralizing antibody response.

13 May 2021

Pfizer-BioNTech COVID-19 vaccine effective in patients with myeloproliferative neoplasms

Researchers in the UK have provided evidence that Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine induces effective immune responses in patients with myeloproliferative neoplasms.

13 May 2021

New drug-like compound could effectively block a critical step in malaria parasite life cycle

Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

12 May 2021

New noninvasive imaging device could be used in biomedical research, translational medicine

A biochemical reaction between an enzyme called luciferase and oxygen causes fireflies to glow and is considered one of the most well-known examples of bioluminescence in nature.

12 May 2021

Investigational gene therapy can restore immune function in children with inherited immunodeficiency disorder

An investigational gene therapy can safely restore the immune systems of infants and children who have a rare, life-threatening inherited immunodeficiency disorder, according to research supported in part by the National Institutes of Health.

12 May 2021

An intranasal COVID-19 vaccine elicits long-lasting immunity against SARS-CoV-2 variants in vivo

A team of scientists from the Washington University School of Medicine and the University of Texas Medical Branch, USA, has recently evaluated the durability and robustness of an adenovirus-vectored, spike-based intranasal COVID-19 vaccine in mice.

11 May 2021

Cerebral organoids provide new insight into role of key enzyme in natural brain development

Like many around the world, the lab of Professor Mriganka Sur in The Picower Institute for Learning and Memory at MIT has embraced the young technology of cerebral organoids, or "minibrains," for studying human brain development in health and disease.

11 May 2021

Researchers design compounds that prevent SARS-CoV-2 entry in human lung cells

Researchers have designed a new class of TMPRSS2 inhibitors that have shown broad antiviral activity against coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

11 May 2021

Experimental gene therapy successfully treats children born without an immune system

An experimental form of gene therapy developed by a team of researchers from UCLA and Great Ormond Street Hospital in London has successfully treated 48 of 50 children born with a rare and deadly inherited disorder that leaves them without an immune system.

11 May 2021

The "key" to vaccine development depends on virus’ binding to human cells

New variants of the SARS-CoV-2 virus most likely will necessitate the development of more vaccine options in the years ahead, and a biomedical scientist at Iowa State University believes the "key" to that development lies in the way the virus binds to human cells.

11 May 2021

Severe COVID-19 linked to genetic clotting predisposition

Thus, the need to stratify the risk of severe or critical disease in patients presenting with SARS-CoV-2 infection remains a crying necessity. A new preprint research paper posted to the medRxiv server discusses the relationship between severe disease and pre-existing susceptibility to clots and other diseases of the cardiovascular system.

11 May 2021

The travel-related origin and spread of SARS-CoV-2 B.1.620 strain

A new preprint research paper posted to the medRxiv* server describes a new variant B.1.620, which appeared in Lithuania, and is now prevalent in several countries in Europe, as well as in central Africa.

11 May 2021

3D printing technique extends the possibilities of lateral flow tests

Researchers at KU Leuven (Belgium) have developed a 3D printing technique that extends the possibilities of lateral flow testing.

10 May 2021

Blocking fat-busting enzyme with a drug compromises cardiac repair during acute heart failure

Blocking the fat-busting enzyme lipoxygenase with a synthetic inhibitor throws the immune system's innate inflammatory response out of whack, compromising cardiac repair during acute heart failure, USF Health researchers found.

10 May 2021

Esophageal cancers turn on ancient viral DNA hidden in our genome

Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago.

10 May 2021

New nanoimmunoassay can detect anti–SARS-CoV-2 antibodies in ultralow-volume blood samples

In a recent study, researchers developed and validated a nanoimmunoassay (NIA) that analyzes 1,024 samples in parallel on a single microfluidic device the size of a USB stick. They detected anti-SARS-CoV-2 IgG antibodies, achieving a sensitivity of 98% and specificity of 100% based on an analysis of 134 pre-pandemic sera (collected in 2013/2014 and 2018) and 155 sera from reverse transcription-polymerase chain reaction (RT-PCR) positive individuals.

10 May 2021

Prevalence of SARS-CoV-2 antibodies in Germany

Seroprevalence studies have proved their worth in estimating the size and directionality of an outbreak of infectious disease, especially the current pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19). A new study posted to the medRxiv* preprint server describes the prevalence of SARS-CoV-2 antibodies in five representative regions of Germany.

10 May 2021

SARS-CoV-2 main protease conformations are temperature-dependent

New research led by Daniel A Keedy of City University of New York, USA, shows the structure of the main protease (Mpro) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative pathogen of coronavirus disease 2019 (COVID-19) – reacts to being heated and cooled. The temperature-dependent conformations could act as potential therapeutic targets to neutralize the virus.

9 May 2021

Researchers identify anti-inflammatory prodrug Minnelide with potential against SARS-CoV-2

Using a transgenic mouse model of COVID-19, they have observed that treatment with Minnelide reduces viral load and inflammation in the lungs and improves survival. The study is currently available on the bioRxiv* preprint server.

9 May 2021

CFTR modulator can be safe, well-tolerated for younger children with common form of cystic fibrosis

Children ages two to five who have the most common form of cystic fibrosis (CF), caused by two copies of the F508 gene mutation, have not had any modulator treatments available to them until recently.

7 May 2021

Enzyme News and Research

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials

Pfizer-BioNTech COVID-19 vaccine effective in patients with myeloproliferative neoplasms

New drug-like compound could effectively block a critical step in malaria parasite life cycle

New noninvasive imaging device could be used in biomedical research, translational medicine

Investigational gene therapy can restore immune function in children with inherited immunodeficiency disorder

An intranasal COVID-19 vaccine elicits long-lasting immunity against SARS-CoV-2 variants in vivo

Cerebral organoids provide new insight into role of key enzyme in natural brain development

Researchers design compounds that prevent SARS-CoV-2 entry in human lung cells

Experimental gene therapy successfully treats children born without an immune system

The "key" to vaccine development depends on virus’ binding to human cells

Severe COVID-19 linked to genetic clotting predisposition

The travel-related origin and spread of SARS-CoV-2 B.1.620 strain

3D printing technique extends the possibilities of lateral flow tests

Blocking fat-busting enzyme with a drug compromises cardiac repair during acute heart failure

Esophageal cancers turn on ancient viral DNA hidden in our genome

New nanoimmunoassay can detect anti–SARS-CoV-2 antibodies in ultralow-volume blood samples

Prevalence of SARS-CoV-2 antibodies in Germany

SARS-CoV-2 main protease conformations are temperature-dependent

Researchers identify anti-inflammatory prodrug Minnelide with potential against SARS-CoV-2

CFTR modulator can be safe, well-tolerated for younger children with common form of cystic fibrosis

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