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FDA-approved drug could revolutionize organ transplantation

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University report that they were able to successfully put tadpoles of Xenopus laevis frogs into a hibernation-like torpor state using donepezil (DNP), a drug approved by the FDA to treat Alzheimer's. The team had previously used another drug, SNC80, to achieve similar results in tadpoles and enhance the survival of whole mammalian hearts for transplants, but SNC80 is not approved for clinical use in humans because it can cause seizures. By contrast, DNP is already being used in the clinic, meaning it potentially could be rapidly repurposed for use in emergency situations to prevent irreversible organ injury while a person is being transported to a hospital.

23 Aug 2024

T cells influence memory of innate immune cells, research shows

Research from Radboud University Medical Center reveals that T cells from the adaptive immune system can manipulate the memory of innate immune cells.

22 Aug 2024

Anti-obesity medication may help to prevent heart attacks and other major cardiac events

The anti-obesity medication semaglutide may help to prevent heart attacks and other major adverse cardiac events among overweight people who have cardiovascular disease, whether or not they also have heart failure, according to a new study led by UCL's Professor John Deanfield.

22 Aug 2024

New 3D imaging tool offers accurate assessment of metabolic health

Mayo Clinic researchers are using artificial intelligence (AI) with an advanced 3D body-volume scanner – originally developed for the clothing industry – to help doctors predict metabolic syndrome risk and severity.

22 Aug 2024

Study reveals long COVID's wide impact on children's health

The kids were correct all along. In the most comprehensive national study since the onset of the COVID-19 pandemic, a team of researchers that includes a Rutgers-organized consortium of pediatric sites has concluded that long COVID symptoms in children are tangible, pervasive, wide ranging and clinically distinct within specific age groups.

22 Aug 2024

New $20 million initiative focuses on community-driven health research

A new $20 million research initiative will engage the people most impacted by health disparities in developing solutions that may help improve their overall health and well-being.

22 Aug 2024

A teen’s murder, mold in the walls: Unfulfilled promises haunt public housing

Blocks from where tourists stroll along the cobblestoned riverfront in this racially divided city, Detraya Gilliard made her way down the dark, ruptured sidewalks of Yamacraw Village, looking for her missing 15-year-old daughter.

22 Aug 2024

Python's remarkable physiology could lead to new medical breakthroughs

Researchers fed pythons who had fasted for 28 days a meal of 25% of their body weight and compared them to snakes who had not been fed.

22 Aug 2024

mRNA therapy shows promise for maple syrup urine disease

Researchers from the University of Pennsylvania, Perelman School of Medicine, Gene Therapy Program, and Moderna, have shown that repeated administration of lipid nanoparticle-encapsulated mRNA therapy significantly extended survival and reduced serum leucine levels in a mouse model of maple syrup urine disease (MSUD).

22 Aug 2024

Study reveals distinct long COVID patterns in children and adolescents

Scientists investigating long COVID in youth found similar but distinguishable patterns between school-age children (ages 6-11 years) and adolescents (ages 12-17 years) and identified their most common symptoms.

21 Aug 2024

Protein encoded by the ASPN gene plays a protective role in pulmonary arterial hypertension

A new study from researchers with UCLA Health and collaborating organizations has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH).

21 Aug 2024

New index identifies school-age children likely to have long COVID

A research team led by the National Institutes of Health's RECOVER Initiative and supported by its Clinical Science Core (CSC) at NYU Langone Health, has designed a new way to identify which school-age children and adolescents most likely have Long COVID.

21 Aug 2024

Study confirms safety of high and low oxygen levels for cardiac surgery patients

Two out of 10 people who receive cardiac surgery are affected by acute kidney injury, prolonging their hospital stay and increasing their risk for chronic kidney disease, cognitive decline and heart failure.

21 Aug 2024

The role of the Mediterranean diet in cardiovascular disease prevention

Researchers perform an updated review of recent studies to evaluate the effectiveness of the Mediterranean Diet in preventing cardiovascular disease.

21 Aug 2024

New risk prediction scale reveals elevated heart failure risk among American Indians

The incidence rate of heart failure was 2- to 3-fold higher among American Indian populations than rates observed in studies focused on other population groups, such as African American, Hispanic or white adults, in a new study published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

21 Aug 2024

Study reveals potential benefits of naloxone in opioid-associated cardiac arrest

Patients who overdose on opioids and have a pulse are often given naloxone (Narcan) by first responders, a common life-saving measure.

21 Aug 2024

Engineered heart tissues uncover new mechanisms in lupus-related heart damage

Cardiovascular disease is the leading cause of death in patients suffering from lupus, an autoimmune disease in which our immune system attacks our own tissues and organs, the heart, blood, lung, joints, brain, and skin.

20 Aug 2024

Gut microbiome discovery paves the way for new heart failure treatments

Cleveland Clinic researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease.

20 Aug 2024

Heart-in-a-box technology enhances success of heart transplants

The risk of early heart failure after heart transplantation is lower if the donor heart is stored in a so-called heart-in-a-box instead of in the usual cooler with ice.

20 Aug 2024

Processed and red meat intake associated with higher diabetes risk

Meat consumption, particularly consumption of processed meat and unprocessed red meat, is associated with a higher type 2 diabetes risk, an analysis of data from 1.97 million participants, published today in The Lancet Diabetes and Endocrinology, has found.

20 Aug 2024