Preclinical News and Research

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Multi-gene test found to be better at identifying older adults at risk for Alzheimer's

A new test that combines the effects of more than two dozen genetic variants, most associated by themselves with only a small risk of Alzheimer's disease, does a better job of predicting which cognitively normal older adults will go on to develop Alzheimer's dementia than testing only for the well-known genetic variant APOE E4, a scientific team led by researchers at UC San Francisco and UC San Diego has found.

22 Sep 2017

Triple-action antibody to be tested as HIV vaccine

Scientists from the National Institutes of Health (NIH) in collaboration with the pharmaceutical company Sanofi have engineered a three-pronged antibody that protected monkeys from two strains of Human Immunodeficiency Virus (HIV) better than the equivalent naturally occurring antibodies.

22 Sep 2017

Novel gene therapy can inhibit, reverse multiple sclerosis in mouse models

Multiple sclerosis can be inhibited or reversed using a novel gene therapy technique that stops the disease's immune response in mouse models, University of Florida Health researchers have found.

21 Sep 2017

Neurohistology: how whole slide scanning impacts workflow

MultiBrain technology can accelerate the R&D preclinical and safety assessment processes many fold and perform them less expensively.

From Huron Technologies 21 Sep 2017

PET imaging helps scientists to study progression of Zika virus infection in mice

For the first time, scientists have used Positron Emission Tomography imaging to study brain inflammation following Zika virus infection in mice, according to a study recently published online in the journal Molecular Imaging and Biology.

19 Sep 2017

Study reveals marijuana's potential effects in individuals at high risk for psychotic disorder

Marijuana may bring on temporary paranoia and other psychosis-related effects in individuals at high risk of developing a psychotic disorder, finds a preliminary study from researchers at Columbia University Medical Center.

14 Sep 2017

Study finds rising trend in suicide attempts among U.S. adults

New data confirm that suicide attempts among U.S. adults are on the rise, with a disproportional effect on younger, socioeconomically disadvantaged adults with a history of mental disorders.

14 Sep 2017

Long periods of sitting may increase early death risk

A new study finds that it isn't just the amount of time spent sitting, but also the way in which sitting time is accumulated during the day, that can affect risk of early death.

12 Sep 2017

New drug treatment linked to higher bladder compliance after spinal cord injury

Researchers have shown that compared to placebo, a drug treatment intended to prevent remodeling of the bladder wall and given within 48 hours after spinal cord injury (SCI) in dogs was associated with significantly higher bladder compliance.

7 Sep 2017

Generic drug used to increase blood flow may improve effectiveness of cancer immunotherapy

Cancer immunotherapy drugs only work for a minority of patients, but a generic drug now used to increase blood flow may be able to improve those odds, a study by Columbia University Medical Center researchers suggests.

7 Sep 2017

Researchers define how cancer drug works in cells, mice and man

Science is very good at determining how drugs work in experimental models. New research out of Dartmouth's Norris Cotton Cancer Center led by Alan Eastman, PhD, helps to bridge the gap when it comes to ensuring that drugs work by the same mechanism in human patients.

7 Sep 2017

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Significant headway has been made in controlling malaria. However, two vexing problems remain: currently available treatments are unable to block transmission of the parasite that causes the disease, and the parasite often becomes resistant to drugs.

7 Sep 2017

Yoganatomy helps medical students to connect, recharge and remember

Take a deep breath in. As you breathe out, answer: what did your internal intercostal muscles do when you took that breath? This isn't a common question in most yoga classes, but it is part of Yoganatomy at the Perelman School of Medicine, a yoga class that combines traditional yoga practice with reinforcement of lessons in gross anatomy.

6 Sep 2017

Second prestigious Queen’s Award for Enterprise received by MR Solutions

MR Solutions has received the prestigious Queen’s Award for Enterprise from the Lord-Lieutenant of Surrey at their Guildford headquarters in September in recognition of their outstanding success in growing international sales. It was only a year earlier that MR Solutions had won the Queen’s Award for Enterprise for Innovation.

From MR Solutions 6 Sep 2017

Mayo Clinic experts move closer to realizing clinical potential of senolytic drugs on aging

Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals.

4 Sep 2017

New approach to treating neonatal hypoxic ischemia improves outcomes in preclinical models

Hypothermia alone, the current standard of care, neuroprotects roughly 50 percent of newborns with moderate to severe hypoxic ischemia. Therefore, half of all affected newborns are left with developmental, cognitive and motor delays including cerebral palsy following injury.

1 Sep 2017

New trial examines whether compound given before and after bypass surgery mitigates cognitive deficits

University of Arizona researchers are collaborating on a Phase 2 trial to determine whether a particular peptide administered before and after coronary bypass surgery mitigates or even reverses cognitive deficits thought to be connected to the procedure.

31 Aug 2017

Beta blockers capable of reducing stress signaling may enhance effectiveness of immunotherapy

While the development of therapies designed to block "checkpoints" within the immune system has been one of the most exciting and noteworthy advances in cancer research in recent years, it's also been one of the most puzzling, leaving researchers to ask: Why don't these new therapies work for more patients, and why is their efficacy in controlling cancerous tumors often short-lived? A research team from Roswell Park Cancer Institute has shown that at least one answer - and an excellent opportunity for unleashing the full potential of these promising immunotherapies - may lie in the body's "fight or flight" reaction to stressors and in drugs already widely used to control and temporarily disable this stress response.

31 Aug 2017

Researchers synthesizing new, first-in-class drug to stop growth of ER-positive breast cancer

Researchers at UT Health San Antonio and two partner institutions are developing a new, first-in-class agent that has stopped the growth of estrogen receptor-positive (ER-positive) breast cancer in its tracks.

30 Aug 2017

New biomedical tool using nanoparticles could improve therapies for many diseases

A new biomedical tool using nanoparticles that deliver transient gene changes to targeted cells could make therapies for a variety of diseases - including cancer, diabetes and HIV - faster and cheaper to develop, and more customizable.

30 Aug 2017

Preclinical News and Research

Multi-gene test found to be better at identifying older adults at risk for Alzheimer's

Triple-action antibody to be tested as HIV vaccine

Novel gene therapy can inhibit, reverse multiple sclerosis in mouse models

Neurohistology: how whole slide scanning impacts workflow

PET imaging helps scientists to study progression of Zika virus infection in mice

Study reveals marijuana's potential effects in individuals at high risk for psychotic disorder

Study finds rising trend in suicide attempts among U.S. adults

Long periods of sitting may increase early death risk

New drug treatment linked to higher bladder compliance after spinal cord injury

Generic drug used to increase blood flow may improve effectiveness of cancer immunotherapy

Researchers define how cancer drug works in cells, mice and man

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Yoganatomy helps medical students to connect, recharge and remember

Second prestigious Queen’s Award for Enterprise received by MR Solutions

Mayo Clinic experts move closer to realizing clinical potential of senolytic drugs on aging

New approach to treating neonatal hypoxic ischemia improves outcomes in preclinical models

New trial examines whether compound given before and after bypass surgery mitigates cognitive deficits

Beta blockers capable of reducing stress signaling may enhance effectiveness of immunotherapy

Researchers synthesizing new, first-in-class drug to stop growth of ER-positive breast cancer

New biomedical tool using nanoparticles could improve therapies for many diseases

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