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New studies in mice support toxic role of aluminum in neurodegenerative conditions

Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer's disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum's neurotoxic effects.

6 Aug 2013

Study observes that long-term use of antihypertensive drugs associated with breast cancer risk

Older women who take certain types of medication to combat high blood pressure may be putting themselves at greater risk for developing breast cancer, according to a new study by a team of Fred Hutchinson Cancer Research Center scientists led by Christopher Li, M.D., Ph.D.

6 Aug 2013

NIH-funded study of aquaporin proteins could hold clues to cataract

Researchers have achieved dynamic, atomic-scale views of a protein needed to maintain the transparency of the lens in the human eye. The work, funded in part by the National Institutes of Health, could lead to new insights and drugs for treating cataract and a variety of other health conditions.

6 Aug 2013

Pupil responses allow communication in locked-in syndrome

Patients who are otherwise completely unable to communicate can answer yes or no questions within seconds with the help of a simple system-consisting of just a laptop and camera-that measures nothing but the size of their pupils.

6 Aug 2013

Researchers identify new type of cell in brain that helps people to keep track of their relative location

Using direct human brain recordings, a research team from Drexel University, the University of Pennsylvania, UCLA and Thomas Jefferson University has identified a new type of cell in the brain that helps people to keep track of their relative location while navigating an unfamiliar environment.

6 Aug 2013

Tumor cell vaccination has potential to enhance anti-tumor responses following allo-HSCT

Chronic lymphocytic leukemia (CLL) is a cancer of the blood and bone marrow that most often affects older adults. CLL responds to bone marrow stem cell transplantation (allo-HSCT); however, the rate of relapse for CLL remains relatively high.

6 Aug 2013

Novel way to dramatically raise potency of drug candidates targeting RNA

Scientists from the Jupiter campus of The Scripps Research Institute (TSRI) have shown a novel way to dramatically raise the potency of drug candidates targeting RNA, resulting in a 2,500-fold improvement in potency and significantly increasing their potential as therapeutic agents.

6 Aug 2013

Study shows how bioactive component in soy foods plays a role against colon cancer

University of Illinois scientists have evidence that lifelong exposure to genistein, a bioactive component in soy foods, protects against colon cancer by repressing a signal that leads to accelerated growth of cells, polyps, and eventually malignant tumors.

6 Aug 2013

Columbia researchers identify 18 new genes that drive glioblastoma multiforme

A team of researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center has identified 18 new genes responsible for driving glioblastoma multiforme, the most common-and most aggressive-form of brain cancer in adults. The study was published August 5, 2013, in Nature Genetics.

6 Aug 2013

Researchers reveal process by which pancreatic inflammation morphs into pancreatic cancer

Researchers at Mayo Clinic in Florida have revealed the process by which chronic inflammation of the pancreas, pancreatitis, morphs into pancreatic cancer. They say their findings point to ways to identify pancreatitis patients at risk of pancreatic cancer and to potential drug therapies that might reverse the process.

6 Aug 2013

NanoViricides, LRRI sign NDA for IND-enabling efficacy studies on FluCide drug candidates

NanoViricides, Inc. said it has signed a non-disclosure agreement with the Lovelace Respiratory Research Institute. The Company intends to enter into a Master Services Agreement with LRRI for the IND-enabling efficacy studies of both its broad-spectrum injectable and oral FluCide drug candidates.

5 Aug 2013

Nano-machine cell killer offers new insight into fight against pathogens

This is a veritable mechanics of aggression on the nanoscale. Certain bacteria, including Staphylococcus aureus, have the ability to deploy tiny darts. This biological weapon kills the host cell by piercing the membrane.

5 Aug 2013

Scientists discover way to target immune system to shrink tumors in mice

St. Jude Children's Research Hospital scientists have discovered a way to target the immune system to shrink or eliminate tumors in mice without causing autoimmune problems. Researchers also found evidence that the same mechanism may operate in humans. The study was published today in the advance online edition of Nature.

5 Aug 2013

Disruption to TOP3B gene increases susceptibility to schizophrenia and a learning disorder

A team of researchers have shown that schizophrenia and a disorder associated with autism and learning difficulties share a common biological pathway. This is one of the first times that researchers have uncovered genetic evidence for the underlying causes of schizophrenia.

5 Aug 2013

Study opens door to possible treatments for variety of mitochondrial diseases

By borrowing a tool from bacteria that infect plants, scientists have developed a new approach to eliminate mutated DNA inside mitochondria-the energy factories within cells. Doctors might someday use the approach to treat a variety of mitochondrial diseases, including the degenerative eye disease Leber hereditary optic neuropathy. The research, published online today in Nature Medicine, was funded by the National Eye Institute, a part of the National Institutes of Health.

5 Aug 2013

Researchers find vital enzyme complex that gets elevated in many cancers

A team of researchers from Philadelphia and Norway has determined the structure of an enzyme complex that modifies one end of most human proteins and is made at elevated levels in numerous forms of cancer. A study in Nature Structural & Molecular Biology, led by researchers at The Wistar Institute, depicts the structure and the means of action of a protein complex called NatA.

5 Aug 2013

Necrostatin-1: A substance which counteracts several of aluminum's neurotoxic effects

New Studies in Mice Support Toxic Role of Aluminum in Neurodegenerative Conditions, According to Report in Restorative Neurology and Neuroscience

3 Aug 2013

New study paves way for novel approaches to protect people from infections

A new study published by University of Utah researchers is paving the way for novel approaches related to how people are immunized to protect them from diseases.

3 Aug 2013

Researchers exploit Japanese supercomputer to achieve largest general neuronal network simulation

By exploiting the full computational power of the Japanese supercomputer, K Computer, researchers from the RIKEN HPCI Program for Computational Life Sciences, the Okinawa Institute of Technology (OIST) in Japan and Forschungszentrum J-lich in Germany have carried out the largest general neuronal network simulation to date.

3 Aug 2013

Plymouth researcher awarded Young Investigator Award by Children's Tumor Foundation

Dr. Lu Zhou, a member of a team of researchers at Plymouth University Peninsula Schools of Medicine and Dentistry whose area of expertise is brain tumours, has been awarded a fellowship by the Children's Tumor Foundation.

3 Aug 2013

B Cell News and Research

New studies in mice support toxic role of aluminum in neurodegenerative conditions

Study observes that long-term use of antihypertensive drugs associated with breast cancer risk

NIH-funded study of aquaporin proteins could hold clues to cataract

Pupil responses allow communication in locked-in syndrome

Researchers identify new type of cell in brain that helps people to keep track of their relative location

Tumor cell vaccination has potential to enhance anti-tumor responses following allo-HSCT

Novel way to dramatically raise potency of drug candidates targeting RNA

Study shows how bioactive component in soy foods plays a role against colon cancer

Columbia researchers identify 18 new genes that drive glioblastoma multiforme

Researchers reveal process by which pancreatic inflammation morphs into pancreatic cancer

NanoViricides, LRRI sign NDA for IND-enabling efficacy studies on FluCide drug candidates

Nano-machine cell killer offers new insight into fight against pathogens

Scientists discover way to target immune system to shrink tumors in mice

Disruption to TOP3B gene increases susceptibility to schizophrenia and a learning disorder

Study opens door to possible treatments for variety of mitochondrial diseases

Researchers find vital enzyme complex that gets elevated in many cancers

Necrostatin-1: A substance which counteracts several of aluminum's neurotoxic effects

New study paves way for novel approaches to protect people from infections

Researchers exploit Japanese supercomputer to achieve largest general neuronal network simulation

Plymouth researcher awarded Young Investigator Award by Children's Tumor Foundation

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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