Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Link between chronic kidney disease and hypoxia

Researchers at the University of Pennsylvania School of Medicine have discovered how low-oxygen conditions can worsen chronic kidney disease (CKD).

20 Dec 2007

New understanding on alcohol's role in developing alcoholic chronic pancreatitis

Chronic, excessive alcohol consumption is a major risk factor for developing chronic pancreatitis (pancreatic inflammation).

18 Dec 2007

New mechanical insights into wound healing and scar tissue formation

New research published today in the Journal of Cell Biology illuminates the mechanical factors that play a critical role in the differentiation and function of fibroblasts, connective tissue cells that play a role in wound healing and scar tissue formation.

18 Dec 2007

Corgenix Medical enters development agreement wth NIH

Corgenix Medical Corporation has announced it has entered into a corporative research and development agreement (CRADA) with the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH).

18 Dec 2007

Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease

A new study by researchers at Hasbro Children's Hospital, the pediatric division of Rhode Island Hospital, and Mount Sinai Hospital, New York, offers new insight into the role that the cystic fibrosis gene plays in the development of gastrointestinal disease.

14 Dec 2007

Discovery of key mechanism underlying idiopathic pulmonary fibrosis

A study led by Massachusetts General Hospital (MGH) researchers may have found a key mechanism underlying idiopathic pulmonary fibrosis (IPF), a usually fatal lung disease for which transplantation is the only successful treatment.

13 Dec 2007

Cell trafficking finding may aid drug development

With findings highlighted on a recent cover of Developmental Cell , researchers at Weill Cornell Medical College in New York City have shed important new light on key trafficking mechanisms within epithelial cells. Epithelial cells line the outside of nearly all organs.

12 Dec 2007

Protein-dependent "switch" regulates intracellular trafficking in epithelial cells

12 Dec 2007

Researchers photograph cystic fibrosis protein interaction

New microscopic pictures show the first-ever physical evidence of interaction between two proteins involved in Cystic Fibrosis (CF) disease.

10 Dec 2007

Molecular technology used to identify unexpected bacteria in cystic fibrosis patients

Molecular technology developed by a University of Colorado at Boulder professor to probe extreme life forms in undersea hydrothermal vents has been used to identify unexpected bacteria strains in the lung fluid of Denver children suffering from cystic fibrosis, findings that may lead to more effective therapies.

4 Dec 2007

Researchers capture key step in process that allows materials to move in and out of cells

A group of Purdue University researchers has captured a key step in the metabolic process that allows materials, such as nutrients and drug treatments, to move in and out of cells.

3 Dec 2007

Benefits of ibuprofen shown to outweigh risks of gastrointestinal bleeding in children with cystic fibrosis

Treatment with ibuprofen is associated with a significantly slower rate of decline in lung function in children and adolescents with cystic fibrosis, according to a new study.

3 Dec 2007

Study of the post-transplant effects of alcohol use among lung donors

A recent study using an animal model of lung transplants shows that chronic alcohol consumption by the donor promotes scarring and airway injury after transplantation.

2 Dec 2007

Bacteria cheat on their mates for own good

Pursuing our own short term interests by cheating on the rest of the population is not the preserve of the human race.

29 Nov 2007

Could stem cells be used to cure Crohn's Disease?

Scientists are investigating whether stem cells could be used to 're-boot' the immune system and provide a cure for Crohn's Disease.

29 Nov 2007

Alcohol may promote scarring and airway injury after transplantation

A recent study using an animal model of lung transplants shows that chronic alcohol consumption by the donor promotes scarring and airway injury after transplantation.

27 Nov 2007

Lung transplants for cystic fibrosis may not be such a good option

Researchers in the United States say lung transplants do little to improve the outcomes for children with severe cystic fibrosis (CF) and often increases their risk of dying.

22 Nov 2007

Pediatric pediatric pulmonary expert comments on study of lung transplants for cystic fibrosis

Commenting on a study of lung transplantation for children with cystic fibrosis, a leading pediatric pulmonologist calls the study “startling” in an editorial in this week's New England Journal of Medicine that accompanies the study.

21 Nov 2007

Lung transplants do more harm than good to children with cystic fibrosis

Lung transplantation, the therapy almost every cystic fibrosis patient (CF) considers at some point to prolong survival, rarely helps children with the disease live longer and, in fact, often increases their risk of dying, University of Utah researchers conclude in the most extensive study of the issue to date.

21 Nov 2007

Carbon monoxide counteracts one side-effect of an anti-cancer drug

Doxorubicin (DOX) is a red-colored anticancer drug that carries serious side effects for the heart, including cardiac muscle deterioration (cardiomyopathy) and scar tissue accumulation in the heart (fibrosis).

21 Nov 2007