Proliferation News and Research

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Long-term stenting of aortic coarctation yields 77% success rate

Researchers from the Congenital Cardiovascular Interventional Study Consortium (CCISC) who evaluated the intermediate and long-term results of stent implantation for aortic coarctation found that cumulative intermediate success was 86%, and cumulative long-term success was 77%. Results of this study appear in the October issue of Catheterization and Cardiovascular Interventions, a journal published by Wiley-Blackwell on behalf of The Society for Cardiovascular Angiography and Interventions.

14 Sep 2010

OSUCCC-James researchers identify experimental agent that targets chronic lymphocytic leukemia

Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) have identified an experimental agent that targets chronic lymphocytic leukemia and perhaps other proliferative disorders of lymphocytes.

14 Sep 2010

Researchers reveal new way of restraining beta-catenin to suppress tumor metastasis

Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis, the protein can be ejected from cells in small vesicles called exosomes. The study appears online on September 13 in the Journal of Cell Biology.

14 Sep 2010

Study finds new therapeutic target for polycystic kidney disease

In work suggesting a new approach to treating polycystic kidney disease (PKD), a leading cause of kidney failure, researchers at Children's Hospital Boston were able to block the formation of fluid-filled cysts, the hallmark of the disease, in a mouse model. Their findings, using a compound that inhibits a receptor known as c-Met, will be published in the September 13th online edition of the Journal of Clinical Investigation.

14 Sep 2010

Sec. of State Clinton discusses Obama administration's foreign policy strategy

In a speech on Wednesday at the Council on Foreign Relations, Secretary of State Hillary Rodham Clinton outlined the Obama administration's approach to foreign policy and said that U.S. "global leadership is essential, even if we must often lead in new ways," the Washington Post reports.

10 Sep 2010

Champions Biotechnology signs agreement to test Cephalon's CEP-32496 in Biomerk Tumorgraft platform

Champions Biotechnology, Inc., an oncology drug development company with a predictive preclinical platform aimed at accelerating the development and enhancing the value of oncology drugs, announced the establishment of an agreement with Cephalon, Inc., a global biopharmaceutical company, for the testing of the Cephalon novel B-Raf inhibitor CEP-32496 in Champions' Biomerk Tumorgraft™ platform.

8 Sep 2010

Synthetic derivative of Retinoic acid can induce cell death

Retinoic acid (RA), a natural derivative of vitamin A, is the basis of a number of treatments against cancer. Nevertheless, it has certain disadvantages, such as the possibility of the appearance of retinoic acid syndrome, present in 25 % of cases and which can lead to death. The development of 4-HPR, a synthetic derivative of RA, has meant a considerable advance due to its greater efficacy compared to its predecessor.

8 Sep 2010

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they slow tumor growth. Now, researchers in the Developmental Therapeutics Program at Fox Chase Cancer Center have identified an activation signal for AurA. They report in the September 7 issue of Nature Communications that a quick increase in the calcium concentration in a cell rapidly triggers AurA kinase activity.

8 Sep 2010

RA synthetic derivative 4-HPR's ability to induce tumour cell death

7 Sep 2010

Research on immune system can develop new therapy for inflammation, tumors

In two closely related studies, two teams of Scripps Research Institute scientists have discovered the underlying mechanisms that activate a type of immune cell in the skin and other organs. The findings may lead to the development of new therapies to treat inflammation, wounds, asthma, and malignant tumors.

3 Sep 2010

Advanced Life Sciences scientific publication demonstrates triterpenoids' potential as anticancer agents

Advanced Life Sciences Holdings, Inc.,a biopharmaceutical company engaged in the discovery, development and commercialization of novel drugs in the therapeutic areas of infection, oncology and respiratory diseases, today announced the publication of a research paper in the journal Bioorganic and Medicinal Chemistry Letters that reports data using the Company's core triterpenoid platform technology in the discovery and development of new cancer therapeutic agents.

31 Aug 2010

RXR-alpha protein helps to protect pigment cells from invasive melanoma: Research

New research on how skin cancer begins has identified adjacent cancer cells that scientists are calling "co-conspirators" in the genesis of melanoma, in findings that could someday hold the key to predicting, preventing and stopping this hard-to-treat cancer before it spreads.

31 Aug 2010

Researchers find infectious disease proliferation in complex networks

A team of researchers led by Dr. Hern-n Makse, professor of physics at The City College of New York (CCNY), has shed new light on the way that information and infectious diseases proliferate across complex networks.

30 Aug 2010

Scientists develop new combined treatment method for skin cancer prevention

Scientists at The University of Texas Health Science Center San Antonio are on to something that should bring joy to sunbathers everywhere. Studies show that certain plant substances, administered in combinations, have the ability to suppress skin cancer development in susceptible mice.

30 Aug 2010

Second-hand smoke triggers complex inflammatory response

Second-hand smoke is associated with a number of diseases and conditions, including cancer, heart disease, and emphysema. It is an irritant to lung tissue and blood vessels, but the processes through which the body reacts to second-hand smoke comprise a mystery scientists are only beginning to unravel. Researchers at the University of Colorado-Denver are currently studying how second-hand smoke affects the lungs of rats, and so far it appears that second-hand smoke triggers a complex inflammatory response.

27 Aug 2010

MCNA announces $2 million to launch HEAL program for childhood asthma management

The mold that spread like a rash across post-Katrina New Orleans did more than destroy homes - it made children with asthma sick. On the fifth anniversary of Hurricane Katrina, experts point to increased sensitivities to environmental asthma triggers as a risk for more severe asthma symptoms and attacks in hundreds of New Orleans children.

27 Aug 2010

American features series on HIV/AIDS: Prevention Strategies, MSM, Idus

A Scientific American series examines how recent scientific advances will guide future efforts to thwart HIV/AIDS and also looks at the epidemic among men who have sex with men (MSM) and injecting drug users (IDUs).

27 Aug 2010

FDA grants LFB's recombinant anti-CD20 monoclonal antibody orphan drug status for CLL

The recombinant anti-CD20 monoclonal antibody produced by LFB Biotechnologies received orphan drug status for the treatment of Chronic Lymphocytic Leukemia (CLL). This approval from the FDA Office of Orphan Products Development was granted on August 6th, 2010.

26 Aug 2010

Research on OGF-OGFr complex helps to understand pathobiology of diseases

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the Opioid Growth Factor (OGF, [Met5]-enkephalin) and its receptor, OGFr, a clinically important system with potent antitumor properties, has controlled entry from the cytoplasm to the nucleus. The nucleocytoplasmic passage of OGF-OGFr is critical to cell proliferation and suggests that there are hierarchical levels of nuclear import.

24 Aug 2010

Research on fruit fly provides inroads into understanding cancer development

Changes to proteins in a cell underlay many cancers. Rui Martinho at the Instituto Gulbenkian de Ci-ncia (IGC), in Portugal, in collaboration with researchers in Ghent (Belgium) and Bergen (Norway) will use the fruit fly to understand exactly how changes to proteins, identified in the test-tube, impact on the way cells divide in a living organism

24 Aug 2010

Proliferation News and Research

Long-term stenting of aortic coarctation yields 77% success rate

OSUCCC-James researchers identify experimental agent that targets chronic lymphocytic leukemia

Researchers reveal new way of restraining beta-catenin to suppress tumor metastasis

Study finds new therapeutic target for polycystic kidney disease

Sec. of State Clinton discusses Obama administration's foreign policy strategy

Champions Biotechnology signs agreement to test Cephalon's CEP-32496 in Biomerk Tumorgraft platform

Synthetic derivative of Retinoic acid can induce cell death

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

RA synthetic derivative 4-HPR's ability to induce tumour cell death

Research on immune system can develop new therapy for inflammation, tumors

Advanced Life Sciences scientific publication demonstrates triterpenoids' potential as anticancer agents

RXR-alpha protein helps to protect pigment cells from invasive melanoma: Research

Researchers find infectious disease proliferation in complex networks

Scientists develop new combined treatment method for skin cancer prevention

Second-hand smoke triggers complex inflammatory response

MCNA announces $2 million to launch HEAL program for childhood asthma management

American features series on HIV/AIDS: Prevention Strategies, MSM, Idus

FDA grants LFB's recombinant anti-CD20 monoclonal antibody orphan drug status for CLL

Research on OGF-OGFr complex helps to understand pathobiology of diseases

Research on fruit fly provides inroads into understanding cancer development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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