Clinical Trial News and Research

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Flexible model of care can be effective in treating opioid use disorder

Did you know that more than 26,500 Canadians died from opioid intoxication between January 2016 and September 2021? Or that more than 350,000 people who used drugs containing opioids to relieve their pain did so problematically?

15 Jun 2022

Androgen receptor signaling affects response to targeted therapy in people with melanoma

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers from The University of Texas MD Anderson Cancer Center showed in a study published today in Nature.

15 Jun 2022

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

A team of researchers led by Dr. Sandra Castillo and Dr. Mariona Graupera, from the Josep Carreras Leukaemia Research Institute and member of the CIBERONC, have found the AKT inhibitor miransertib could be a new molecular treatment effective against low-flow vascular malformations, a long-awaited milestone.

14 Jun 2022

Varenicline improves quit rates among African American daily smokers

African Americans have been underrepresented in tobacco treatment research, including the clinical trials that led to the 2006 FDA approval of varenicline, the leading pharmacological treatment for smoking cessation commonly known by the brand name Chantix.

14 Jun 2022

Center-based childcare may improve health and developmental outcomes in children

A new study conducted in Canada found that children who attended center-based childcare between 1 and 4 years of age had a lower body mass index (BMI) and were less likely to be overweight or obese in later childhood than children who had non-parental childcare that was home-based or provided by relatives or nannies.

14 Jun 2022

New potato processing technique slows starch digestion to avoid blood sugar spikes

Researchers announced early tests of a new potato processing technique designed to make our bodies digest potato starch more slowly.

14 Jun 2022

Study: Uterine transplantation is an effective, safe method to remedy infertility

Transplanting a uterus is an effective, safe method to remedy infertility when a functioning uterus is lacking.

14 Jun 2022

New research provides credible estimates for prevalence of Alzheimer’s-like brain disorder

New National Institutes of Health-funded research shows that the prevalence of brain changes from Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) may be roughly 40% in older adults and as high as 50% in people with Alzheimer's disease.

13 Jun 2022

Study provides the most definitive assessment of new non-Alzheimer’s dementia

Researchers from the University of Kentucky's Sanders-Brown Center on Aging say a paper recently published in Acta Neuropathologica is the most definitive assessment yet of the prevalence of a form of dementia classified in 2019 and now known as LATE.

13 Jun 2022

Treatment with immunity-boosting protein enhances the function of CAR-T cells in fighting blood cancers

Advances in cellular immunotherapy that spur genetically modified T cells to attack cancer cells have revolutionized the treatment of certain blood cancers.

13 Jun 2022

The potential role of Ginkgo biloba L. folium extract in the management of COVID-19

Researchers explored the effectiveness of Ginkgo biloba L. folium extract (EGb) in the management of COVID-19 severity.

13 Jun 2022

AI tool allows clinicians to make optimal, personalized chemotherapy doses for patients

A team of researchers from National University of Singapore, in collaboration with clinicians from the National University Cancer Institute, Singapore which is part of the National University Health System (NUHS), has reported promising results in using CURATE.AI, an artificial intelligence (AI) tool that identifies and better allows clinicians to make optimal and personalized doses of chemotherapy for patients.

13 Jun 2022

Inhaled vaccines provide better protection and stronger immunity than nasal sprays, study confirms

McMaster University scientists who compared respiratory vaccine-delivery systems have confirmed that inhaled aerosol vaccines provide far better protection and stronger immunity than nasal sprays.

10 Jun 2022

Creating CAR T cells without an immune brake

T cells are usually very good at eliminating diseased cells. But they seem to fail when it comes to tumor cells.

10 Jun 2022

The physiological relevance and effects of probable in vivo transformation of CBD to delta9-THC in humans

Researchers reviewed studies on the probable conversion of orally administered cannabidiol (CBD) to delta9-tetrahydrocannabinol (delta9-THC or THC) in humans.

10 Jun 2022

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

A drug used to target IDH1 mutations in select cancers also appears to inhibit the wild-type form of the enzyme, under certain conditions.

9 Jun 2022

Inhaled recombinant IL-15 tested in pet dogs with metastatic lung disease from osteosarcoma or melanoma

A protein that the body naturally produces could become an important new immunotherapy drug in the cache of cancer-fighting tools available to oncologists.

9 Jun 2022

Aspirin changes the way colorectal cancer cells evolve over time, study reveals

Cancer starts when cells start dividing uncontrollably. Scientists have known that taking aspirin can help protect against the development of colorectal cancer – cancer afflicting the colon or rectum – but the exact reason aspirin has this effect has been mostly a mystery.

9 Jun 2022

Largest-ever series of case studies shows phage therapy’s success in more than half of the patients

The number of reported cases using viruses to treat deadly Mycobacterium infections just went up by a factor of five. In a new study, a team led by researchers from the University of Pittsburgh and the University of California San Diego report 20 new case studies on the use of the experimental treatment, showing the therapy's success in more than half of the patients.

9 Jun 2022

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

Insilico Medicine's end-to-end AI-driven drug discovery platform, Pharma.AI, draws its strength from the quality and quantity of its data. As Insilico scientific advisory board member and Nobel Prize laureate in chemistry Dr. Michael Levitt has said, Insilico's platform capitalizes on the ability of artificial intelligence to take vast amounts of data from many different components and find patterns and make predictions that can point the way to new life-saving medications.

9 Jun 2022

Clinical Trial News and Research

Flexible model of care can be effective in treating opioid use disorder

Androgen receptor signaling affects response to targeted therapy in people with melanoma

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

Varenicline improves quit rates among African American daily smokers

Center-based childcare may improve health and developmental outcomes in children

New potato processing technique slows starch digestion to avoid blood sugar spikes

Study: Uterine transplantation is an effective, safe method to remedy infertility

New research provides credible estimates for prevalence of Alzheimer’s-like brain disorder

Study provides the most definitive assessment of new non-Alzheimer’s dementia

Treatment with immunity-boosting protein enhances the function of CAR-T cells in fighting blood cancers

The potential role of Ginkgo biloba L. folium extract in the management of COVID-19

AI tool allows clinicians to make optimal, personalized chemotherapy doses for patients

Inhaled vaccines provide better protection and stronger immunity than nasal sprays, study confirms

Creating CAR T cells without an immune brake

The physiological relevance and effects of probable in vivo transformation of CBD to delta9-THC in humans

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

Inhaled recombinant IL-15 tested in pet dogs with metastatic lung disease from osteosarcoma or melanoma

Aspirin changes the way colorectal cancer cells evolve over time, study reveals

Largest-ever series of case studies shows phage therapy’s success in more than half of the patients

Insilico Medicine plans to launch a fully automated AI-driven robotics lab for drug discovery

eBook: Using iPSCs models for human disease research and drug discovery eBook

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