Clinical Trial News and Research

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Revolutionary mRNA vaccine technology: History, facts and the future

mRNA vaccine technology is a field full of promise – as well as unanswered questions – for communities living with the burden of the world’s most deadly infectious diseases.

20 Apr 2022

Advancements in HIV science

As far as viruses go, human immunodeficiency virus (HIV) is quite simple. About 100,000 times smaller than a red blood cell, the virus expresses just a dozen proteins, yet it can establish a lifelong infection that, if left untreated, causes acquired immunodeficiency syndrome (AIDS) and death.

20 Apr 2022

New findings reveal the long-standing underrepresentation of women in cardiology leadership roles

In a trio of studies analyzing trends in cardiology research funding, clinical trials and leadership, Johns Hopkins Medicine researchers say some progress has been made in the gender gap that has long favored men, but inequalities persist and are likely linked to ongoing disparities in outcomes for women with heart disease.

20 Apr 2022

Scientists receive $4.6 million for a program that matches mental health patients with psychotherapists

A University of Massachusetts Amherst psychologist has received a $4.6 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) to implement a program that matches mental health patients with psychotherapists based on the therapist's previously established effectiveness strengths.

20 Apr 2022

Scientists create a bioengineered 3D model that mimics the biology of two rare neuromuscular diseases

A scientific team supported by the National Institutes of Health has created a tiny, bioengineered 3-D model that mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, a pair of rare, devastating neuromuscular diseases.

19 Apr 2022

Why cheap, older drugs that might treat covid never get out of the lab

In March 2020, Dr. Joseph Vinetz left the contemplative world of his Yale University infectious-disease laboratory and plunged into the covid ward at Yale New Haven Hospital, joining an army of health care workers who struggled to treat the deadly viral disease.

19 Apr 2022

New research on immune correlates for Janssen Ad26.Cov2.S COVID vaccine

ENSEMBLE data was used to evaluate three immune markers as correlates of protection following a single dose of Ad26.COV2.S vaccine.

18 Apr 2022

Researchers develop and validate polygenic risk scores for six common diseases

A person's risk of developing diseases such as type 2 diabetes or breast cancer may be influenced by thousands of genetic differences.

18 Apr 2022

Noninvasive sound technology could lead to improved cancer outcomes in humans

Noninvasive sound technology developed at the University of Michigan breaks down liver tumors in rats, kills cancer cells and spurs the immune system to prevent further spread—an advance that could lead to improved cancer outcomes in humans.

18 Apr 2022

Delivery technologies of mRNA and pDNA for advanced therapeutic applications

Innovation Center of NanoMedicine (Center Director: Prof. Kazunori Kataoka) has announced that Prof. Satoshi Uchida (Principal Research Scientist), who is also Associated Professor of the Kyoto Prefectural University of Medicine, published an article review about non-viral messenger RNA (mRNA) and plasmid DNA (pDNA) delivery by addressing the various delivery technologies of mRNA and pDNA, from basic research to therapeutic and clinical application; Pharmaceutics 2022, 14(4), 810.

15 Apr 2022

New study paves the way for first drug treatment for sleep apnea

A new University of Gothenburg study has paved the way for the first drug treatment for sleep apnea. Compared to before receiving the treatment, breathing pauses decreased with on average more than 20 per hour for patients given the drug.

15 Apr 2022

New short-course treatment effective against HIV-associated cryptococcal meningitis

A new short-course treatment is effective against HIV-associated cryptococcal meningitis with fewer serious side effects, and has the potential to reduce the length and cost of hospital admissions, a study shows.

15 Apr 2022

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022

The preclinical potential of S. miltiorrhiza extracts for the treatment of COVID-19

In a recent study, researchers assessed the anti-COVID-19 efficacy of Salvia miltiorrhiza Bunge.

14 Apr 2022

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate treatment resistance, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

13 Apr 2022

Harnessing electricity to treat certain types of cancer

Electricity has formed the basis of many aspects of the modern world, from providing reliable sources of light to powering home appliances and computers.

12 Apr 2022

New COVID-19 vaccine induces T-cell immune responses in most patients with B-cell deficiencies

CoVac-1, a new vaccine against SARS-CoV-2, induced T-cell immune responses in 93 percent of patients with B-cell deficiencies, including many patients with leukemia and lymphoma, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

12 Apr 2022

Clinical Trial News and Research

Revolutionary mRNA vaccine technology: History, facts and the future

Advancements in HIV science

New findings reveal the long-standing underrepresentation of women in cardiology leadership roles

Scientists receive $4.6 million for a program that matches mental health patients with psychotherapists

Scientists create a bioengineered 3D model that mimics the biology of two rare neuromuscular diseases

Why cheap, older drugs that might treat covid never get out of the lab

New research on immune correlates for Janssen Ad26.Cov2.S COVID vaccine

Researchers develop and validate polygenic risk scores for six common diseases

Noninvasive sound technology could lead to improved cancer outcomes in humans

Delivery technologies of mRNA and pDNA for advanced therapeutic applications

New study paves the way for first drug treatment for sleep apnea

New short-course treatment effective against HIV-associated cryptococcal meningitis

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

The preclinical potential of S. miltiorrhiza extracts for the treatment of COVID-19

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Harnessing electricity to treat certain types of cancer

New COVID-19 vaccine induces T-cell immune responses in most patients with B-cell deficiencies

Aprotinin could inhibit virus replications by preventing SARS-CoV-2 entry into host cells

Thousands more vulnerable patients are eligible to receive the UK’s second antiviral for COVID-19

Alternative anti-HIV strategy generates promising results in a phase I clinical trial

Event guide: 15th World Clinical Biomarkers & CDx Europe eBook

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