Immune Response News and Research

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Circular RNA vaccine shows neutralizing activity against B.1.351 variant

New preclinical research led by Wensheng Wei from Peking University in China has proposed the development of a circular RNA vaccine. Their findings showed the circular RNA vaccine creates neutralizing antibodies and strong T-cell responses against the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

21 Mar 2021

New approach to cancer immunotherapy may prevent autoimmunity

A team of researchers has found disrupting the interaction between cancer cells and certain immune cells is more effective at killing cancer cells than current immunotherapy treatments.

19 Mar 2021

Developing a COVID-19 vaccine using inactivated E. coli

A team of researchers inactivated whole-cell E.coli with a reduced genome and utilized this to express coronavirus-specific fusion peptides, demonstrating a potent anamnestic response.

19 Mar 2021

New variant may not have changed COVID-19 pandemic course in UK, says study

A new study examines the effect of the new "Kent variant" of SARS-CoV-2 on the epidemic course within the UK.

19 Mar 2021

N-terminal domain antibodies play a key role in COVID immunity

Scientists are learning that a lesser-studied region on the pandemic coronavirus is recognized by COVID-19 infection-fighting antibodies. These antibodies were identified in blood samples from previously infected patients, and were found to potently prevent the virus from infecting cells.

19 Mar 2021

Engineering immunogens to focus immune response to SARS-CoV-2

Researchers have designed constructs by adding more glycans and adding the receptor-binding motif from related sarbecoviruses to focus the immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding motif. Such immunogens could potentially also neutralize other variants and coronaviruses.

18 Mar 2021

Study reveals biomarkers for the prognosis of gastric adenocarcinoma

Low plasma levels of protein TGFB1 and polymorphisms in gene TGFB1 act as biomarkers for the prognosis of gastric adenocarcinoma, according to a study led by the University Complutense of Madrid.

18 Mar 2021

A modified protein mediates development of lung fibrosis after cadmium/carbon black exposure

The triggers and causes of a severe scarring disease of the lungs -- idiopathic pulmonary fibrosis, or IPF -- remain unclear.

18 Mar 2021

Progesterone therapy may improve clinical outcomes for male COVID-19 patients

COVID-19 disproportionately affects men compared with women, raising the possibility that a hormone like progesterone may improve clinical outcomes for certain hospitalized men with the disease.

18 Mar 2021

Novel cancer-fighting gene therapy enters phase I clinical trial

Researchers from the MDC and Charité have developed a new gene therapy based around a special T-cell receptor that helps the immune system effectively recognize and fight cancer cells.

18 Mar 2021

Study reveals unknown immune defense system that protects the lungs from viral infections

Researchers have uncovered a previously unknown arm of the immune defence system that protects the lung from lethal viral infections.

18 Mar 2021

Can vaccine evading SARS-CoV-2 variants be restricted by prioritized vaccine rollout?

A new study discusses the question of how vaccine priority is affected by the possibility of vaccine escape.

18 Mar 2021

Could cinnamon modulate the immune response in severe COVID-19?

A new study describes the potential for two common plant products to make a difference in the management of severe COVID-19.

18 Mar 2021

Study characterizes shifting neoantigen burden between primary and metastatic tumors within HNSCC

Oncotarget published "Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma" which reported that prior work has characterized changes in the mutation burden between primary and recurrent tumors; however, little work has characterized the changes in neoantigen evolution.

18 Mar 2021

Long noncoding RNA plays a vital role in mobilizing immune response after organ transplantation

A long noncoding RNA whose function was previously unknown turns out to play a vital role in mobilizing the immune response following a bone marrow transplant or solid organ transplantation.

17 Mar 2021

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

TARM1 is a receptor protein whose role in the functioning of the immune system is unknown. In a new study, scientists from Japan have explored the potential role of TARM1 in the pathogenesis of rheumatoid arthritis by analyzing mouse models.

17 Mar 2021

Can vaccination and infection rates add up to reach Covid herd immunity?

It's been a long, dark winter of Covid concerns, stoked by high post-holiday case counts and the American death tally exceeding 530,000 lives lost.

17 Mar 2021

Researchers explore difference in reactions to SARS-CoV-2 infection between children and adults

The COVID-19 pandemic has claimed over 2.67 million lives in less than a year and a half. However, it is uncommon in children, with less than 2% of the cases being in individuals below the age of 19. Most of these are of mild severity, with the clinical features of severe COVID-19 being rare in this age group.

17 Mar 2021

Living with a COVID-19 case brings worse symptoms and stronger antibody response

This study suggests that high virus exposure levels contribute to greater disease severity and stronger antibody responses. The observations from this study are published on the medRxiv preprint server.

17 Mar 2021

Scientists explore the negative effects of prenatal stress on offspring mental health

The link between psychological stress and physical health problems generally relates to a stress-induced immune response gone wild, with inflammation then causing damage to other systems in the body. It's a predictable cascade - except in pregnancy, research suggests.

16 Mar 2021

Immune Response News and Research

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

New approach to cancer immunotherapy may prevent autoimmunity

Developing a COVID-19 vaccine using inactivated E. coli

New variant may not have changed COVID-19 pandemic course in UK, says study

N-terminal domain antibodies play a key role in COVID immunity

Engineering immunogens to focus immune response to SARS-CoV-2

Study reveals biomarkers for the prognosis of gastric adenocarcinoma

A modified protein mediates development of lung fibrosis after cadmium/carbon black exposure

Progesterone therapy may improve clinical outcomes for male COVID-19 patients

Novel cancer-fighting gene therapy enters phase I clinical trial

Study reveals unknown immune defense system that protects the lungs from viral infections

Can vaccine evading SARS-CoV-2 variants be restricted by prioritized vaccine rollout?

Could cinnamon modulate the immune response in severe COVID-19?

Study characterizes shifting neoantigen burden between primary and metastatic tumors within HNSCC

Long noncoding RNA plays a vital role in mobilizing immune response after organ transplantation

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

Can vaccination and infection rates add up to reach Covid herd immunity?

Researchers explore difference in reactions to SARS-CoV-2 infection between children and adults

Living with a COVID-19 case brings worse symptoms and stronger antibody response

Scientists explore the negative effects of prenatal stress on offspring mental health

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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