Acute Respiratory Distress Syndrome News and Research

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CRISPR screening identifies human host pathways that facilitate coronavirus infection

The human coronavirus family consists of 7 known pathogens, for which there are no approved vaccines or specific therapeutic options. Although the seasonal human coronaviruses - OC43, HKU1, 229E, and NL63 – only cause mild respiratory infections, three highly pathogenic coronaviruses that emerged in the last two decades revealed the pandemic potential of this family of viruses.

27 Sep 2020

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

A multinational research group recently published a paper in the journal Lancet Respiratory Medicine which describes the first patient with a severe form of coronavirus disease (COVID-19) that was successfully treated with human recombinant soluble ACE2.

27 Sep 2020

Shorter time from COVID-19 symptom onset to hospitalization linked to disease severity, death

New research presented at this week's ESCMID Conference on Coronavirus Disease (ECCVID, held online) shows that a shorter time from symptom onset to hospitalization is associated with more serious disease and death in patients with COVID-19.

26 Sep 2020

ECMO appears to be saving the lives of many critically ill COVID-19 patients

It saved lives in past epidemics of lung-damaging viruses. Now, the life-support option known as ECMO appears to be doing the same for many of the critically ill COVID-19 patients who receive it, according to a new international study.

26 Sep 2020

Linoleic acid binds SARS-CoV-2 spike protein

Now, a team of researchers at the Max Planck-Bristol Center for Minimal Biology and Bristol's School of Biochemistry has identified a druggable pocket in the virus's spike protein that can be used to prevent the infection of cells. The study findings, published in the journal Science, are a groundbreaking discovery that will help develop new therapies and drugs to stem the growing pandemic.

24 Sep 2020

Most people with COVID-19 develop symptoms, study says

A new study by researchers at the University of Bern and published in the journal PLOS Medicine reports that while some people never experience any symptoms, most of those infected with the novel coronavirus do develop symptoms.

23 Sep 2020

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Using bioinformatics approaches, researchers have identified genes and pathways shared among patients with comorbidities and having severe COVID-19. The research is published on the preprint server bioRxiv in September 2020.

23 Sep 2020

Children exhibit distinct immune system responses against COVID-19

Children and adults exhibit distinct immune system responses to infection by the virus that causes COVID-19, a finding that helps explain why COVID-19 outcomes tend to be much worse in adults, researchers from Yale and Albert Einstein College of Medicine report Sept. 18 in the journal Science Translational Medicine.

23 Sep 2020

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

Researchers at the University of Cincinnati and UC Health will host a Phase 2 clinical trial (NCT04511650) to examine the effects of a drug that targets blood vessel inflammation and injury in patients with COVID-19.

22 Sep 2020

Study detects key differences in immune responses of adults and children with COVID-19

The first study comparing the immune responses of adults and children with COVID-19 has detected key differences that may contribute to understanding why children usually have milder disease than adults.

22 Sep 2020

Using computer simulations to examine personalized mechanical ventilation of COVID-19 patients

Initial clinical guidelines for mechanical ventilation of COVID-19 patients suggested following standard approaches used in the treatment of acute respiratory distress syndrome (ARDS), which is characterized by rapid onset of widespread inflammation in the lungs.

21 Sep 2020

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

A team of researchers from Aix-Marseille Univ, IHU-Méditerranée Infection, Institut Paoli Calmettes and Laboratoire d’Immunologie, Marseille, France, conducted experiments to determine if SARS-CoV-2 can affect the myeloid compartment or infect monocytes and macrophages.

20 Sep 2020

Key China COVID-19 study produced results that influenced subsequent research on coronavirus

Early in the onset of the COVID-19 pandemic, a small study in China produced results that influenced subsequent research on the virus.

18 Sep 2020

Biomarker predicts disease severity in COVID-19 patients

Airway cell analyses showing an activated immune axis could pinpoint the COVID-19 patients who will most benefit from targeted therapies.

17 Sep 2020

LOX-1-immature neutrophils may help identify COVID-19 patients at risk of thrombosis complication

To predict severe outcome in COVID-19 patients, innate immune cellular signals are analyzed, identifying two novel neutrophil subsets: LOX-1- and CD123-expressing CD10-CD64+. Thromboembolic events correlated with high LOX-1 immature neutrophils – a potential prognostic signature.

17 Sep 2020

Acute Respiratory Distress Syndrome News and Research

CRISPR screening identifies human host pathways that facilitate coronavirus infection

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

Shorter time from COVID-19 symptom onset to hospitalization linked to disease severity, death

ECMO appears to be saving the lives of many critically ill COVID-19 patients

Linoleic acid binds SARS-CoV-2 spike protein

Most people with COVID-19 develop symptoms, study says

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Children exhibit distinct immune system responses against COVID-19

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

Study detects key differences in immune responses of adults and children with COVID-19

Using computer simulations to examine personalized mechanical ventilation of COVID-19 patients

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

Key China COVID-19 study produced results that influenced subsequent research on coronavirus

Biomarker predicts disease severity in COVID-19 patients

LOX-1-immature neutrophils may help identify COVID-19 patients at risk of thrombosis complication

Sticky DNA webs may cause tissue damage associated with severe COVID-19 infections

Researchers develop new PET imaging agent that spotlights inflammation

Convalescent plasma fails to improve outcome of COVID-19 in India

Brain inflammation seen in fatal COVID-19 cases

Convalescent plasma could be an effective treatment for children with COVID-19

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