Study examines the long-term health effects of vaping, e-cigarettes on children

Adolescent use of e-cigarettes and vaping products is at epidemic proportions, yet the adverse health effects are understudied, with almost no data on younger patients. The problem is sizable as children start vaping at a younger and younger age.

Recent estimates show that 9.6 percent of eighth graders vape nicotine or THC (tetrahydrocannabinol, the main active ingredient of cannabis), along with 19.9 percent of 10th graders and 25.5 percent of 12th graders. Many young people vape daily.

Secondary exposure to traditional combustible cigarettes has well-established side effects, including respiratory illness, prematurity and lower quality of life. Far less is known about secondary exposure to vaping, though a majority of studies conclude it poses health risks.

A team of researchers, led by Robinder Khemani, MD, MSci, Associate Director of Research for the Department of Anesthesiology Critical Care Medicine at The Saban Research Institute of Children's Hospital Los Angeles, is determined to develop new evidence of vaping's health effects on adolescents.

Dr. Khemani recently received a $500,000 grant from the National Heart, Lung and Blood Institute (NHLBI) to study the long-term health effects of vaping and secondary exposure to electronic cigarettes on children and teens.

Most compounds in e-cigarettes have not been thoroughly assessed for safety, and some toxins occur at higher concentrations in e-cigarettes than combustible cigarettes."

Dr. Robinder Khemani, Associate Director of Research, Department of Anesthesiology Critical Care Medicine, The Saban Research Institute, Children's Hospital Los Angeles

His team is focused on studying a new condition the Centers for Disease Control and Prevention (CDC) calls EVALI, for "e-cigarette or vaping product use-associated lung injury." The illness was first recognized by the CDC in the summer of 2019 when cases of sudden, severe, sometimes fatal lung infections began emerging, often in otherwise healthy individuals.

As of December 2019, 2,409 hospitalizations had been logged in the United States for EVALI, with 52 deaths. Sixteen percent of cases involved patients under the age of 18. Doctors have found at least one commonality among the patients--recent use of e-cigarettes or vaping products.

Dr. Khemani's NHLBI-funded study is an extension of a Phase II clinical trial he is leading--

REDvent ("Real-time Effort Driven VENTilator)--which is testing a new way to manage patients on ventilators. The novel computer-based approach is designed to preserve respiratory muscle strength and reduce a patient's time on mechanical ventilation.

About 90 percent of trial participants, who range in age from 1 month to 18 years, have had pediatric acute respiratory distress syndrome (PARDS), a rapidly progressing disease that causes fluid to leak into the lungs, making it difficult to breathe.

The e-cigarette study is concentrating on children who come to the ICU with PARDS, which is typically triggered by an infection in children, and is asking if the lung injury experienced from vaping is similar to lung injury resulting from other PARDS triggers.

One of the study's unique aspects is its examination of secondary exposure to vaping's effects and whether this increases a child's susceptibility to more severe lung injury when they get PARDS from other causes or if it makes their recovery from PARDS more difficult.

The study will compare clinical data between adolescents with EVALI and those with PARDS from other causes. Dr. Khemani's team also wants to find out whether exposure of any kind to e-cigarettes influences illness severity and clinical outcomes when children develop PARDS.

Parents often vape indoors or in enclosed spaces such as cars, without thinking they are exposing their children to potential toxins."

Dr. Robinder Khemani, Associate Director of Research, Department of Anesthesiology Critical Care Medicine, The Saban Research Institute, Children's Hospital Los Angeles

In total, he expects to follow about 350 children and teens. "We hope to debunk the myth that vaping is benign," he says.


  1. mittens B mittens B United States says:

    I’ve been vaping for 10 years and I’ve had no respiratory problems. My lungs were far worse after smoking for 4 years than vaping for 10 years. I can run again without feeling like I’m going to pass out. Obviously abstinence is optimal but between smoking and vaping it’s not even close. The lung injury was being caused by black market THC liquid not nicotine or commercially available THC products.

    • Big K K Big K K United States says:

      Exactly I love how these articles always leave that part out.  Legit e cigs and vape mods and juice are not dangerous.  These people vaped black market poison.  Love how the Dr shows his biased with stating his goal

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
You might also like...
Adolescents in the war-region experienced high trauma and daily stress, study shows