Antiretroviral News and Research

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New way to thwart HIV infection at early stages

1.7 million. That's how many people are infected with the human immunodeficiency virus (HIV) each year worldwide. 1.7 million people who are condemned to lifelong antiretroviral therapy (ART) or risk developing fatal AIDS . Out of the 37.9 million people living with HIV (PLWH), 22.3 million have access to ART, allowing them to have an almost normal lifespan.

26 Nov 2019

HIV diagnosis falls to a record low in NYC, finds report

Reporting of new cases of HIV started in 2001 and since then there has been a steady rise and stability of numbers. In 2018 for the first time in nearly two decades, researchers have reported number of new cases to be below 2,000 over the year. This is a record 67 percent decline in the numbers since 2001, says the report. Further the decline in the numbers has been seen in nearly all age groups between 2017 and 2018.

25 Nov 2019

How HIV self-testing affects diagnosis and behaviour in MSM

Men who have sex with men (MSMs) are among the most high-risk groups for acquiring and transmitting HIV infection. A new study published in the journal JAMA Internal Medicinesays that the rate of detection of new infections is more than doubled when self-testing is available. This could increase access to early treatment and thus interrupt the chain of transmission among MSMs.

18 Nov 2019

Children born to women on HIV therapy more likely to have microcephaly, developmental delays

Children born to women on HIV therapy containing the drug efavirenz were 2 to 2.5 times more likely to have microcephaly, or small head size, compared to children born to women on regimens of other antiretroviral drugs, according to an analysis funded by the National Institutes of Health.

18 Nov 2019

HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

Adolescents and young adults who were born to mothers with HIV but remained uninfected themselves still face a greatly heightened risk of obesity and asthma-like symptoms, researchers from Massachusetts General Hospital have found.

15 Nov 2019

Study sheds light on how HIV infection may increase risk for sudden cardiac death

The success of antiretroviral therapies has extended the lives of people living with HIV, long enough for other chronic health conditions to emerge, including a recently documented uptick in sudden death.

14 Nov 2019

FIRS calls for an end to preventable deaths from pneumonia

In support of World Pneumonia Day, Nov. 12, the Forum of International Respiratory Societies, of which the American Thoracic Society is a member, calls for an end to preventable pneumonia deaths, ensuring equitable access to interventions for prevention and control of pneumonia.

12 Nov 2019

New model could predict response of HIV-infected individuals to cancer immunotherapy

A group of researchers at UPF and the Marchuk Institute of Numerical Mathematics in Moscow, Russia, have designed a mathematical model to predict the response of HIV-infected individuals to a type of cancer immunotherapy.

7 Nov 2019

HIV-1 virus characteristics can predict treatment efficacy with specific antibody treatment

Current HIV-1 therapies have been proven to be highly effective in slowing the progression of the virus in the body with only minimal side effects.

6 Nov 2019

Homeopathy quackery - NHS leaders urge caution

A new controversy is ripe, what with the head of the UK National Health Service (NHS), Simon Stevens, publicly expressing his “serious concerns” about the “fundamentally flawed” practice of homeopathy.

29 Oct 2019

Optimal implementation of existing, new interventions essential to end HIV pandemic

Optimal implementation of existing HIV prevention and treatment tools and continued development of new interventions are essential to ending the HIV pandemic, National Institutes of Health experts write in a commentary Clinical Infectious Diseases.

24 Oct 2019

ConvertibleCAR immunotherapy can be used to attack HIV latent reservoir

A team of Gladstone scientists and their partners at Xyphos Biosciences, Inc. describe a new way of attacking cells infected by HIV in this week's issue of the journal Cell.

24 Oct 2019

New collaboration aims to develop gene-based cures for sickle cell disease and HIV

The National Institutes of Health plans to invest at least $100 million over the next four years toward an audacious goal: develop affordable, gene-based cures for sickle cell disease and HIV.

23 Oct 2019

New findings highlight the 'PrEP gap' for men who have sex with men in the EU

This estimate on the "PrEP gap" in Europe was published in a paper in Eurosurveillance today stating that 500 000 men who have sex with men in the European Union currently cannot access HIV pre-exposure prophylaxis (PrEP), despite being very likely to use it.

11 Oct 2019

Scientists find new evidence on latent HIV reservoir

Antiretroviral therapy (ART) can suppress HIV to the point where the virus is nearly undetectable, and people on medication can live many years.

10 Oct 2019

Initial use of ART alters host environment to allow formation of long-lived HIV reservoir

Antiretroviral therapy (ART) can suppress HIV to the point where the virus is nearly undetectable, and people on medication can live many years. But therapy cannot completely eradicate the virus; it persists in reservoirs inside immune cells, a phenomenon called "latency."

9 Oct 2019

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

The cover for issue 54 of Oncotarget features Figure 2, "Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples," by Lu, et al.

4 Oct 2019

Dormant HIV reservoirs could be killed with RNA switch

Researchers from the University of California San Diego School of Medicine have found cellular triggers within the immune cells that could be controlled in order to kill dormant HIV-1 reservoirs in individuals with HIV-1.

25 Sep 2019

Researchers identify key switch that eliminates dormant HIV reservoirs

Using genetic sequencing, University of California San Diego School of Medicine researchers have identified a principal cellular player controlling HIV reproduction in immune cells which, when turned off or deleted, eliminates dormant HIV reservoirs.

24 Sep 2019

Wistar awarded more than $12 million to study opioid use in HIV-infected people

The Wistar Institute was awarded two major grants totaling more than $12 million from the National Institute on Drug Abuse, part of the National Institutes of Health, to fund an international multidisciplinary clinical research consortium spearheaded by Wistar's HIV Research Program.