Spleen News and Research

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Antihypotensive agent for sepsis disrupts the immune system, increases susceptibility to infections

Patients who go into shock caused by sepsis (septic shock) are treated with the antihypotensive agent norepinephrine.

11 Jun 2020

Transforming spleen to liver could bring new hope for patients suffering from organ shortage

Scientists from Nanjing University and University of Macau have transformed the spleen into a functioning liver in living mice, which could bring new hope for patients suffering from organ shortage worldwide.

11 Jun 2020

Anticardiolipin antibodies and COVID-19

A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19.

10 Jun 2020

COVID-19 mouse model could accelerate the search for treatments, vaccines

The global effort to quickly develop drugs and vaccines for COVID-19 has been hampered by limited numbers of laboratory mice that are susceptible to infection with SARS-CoV-2, the virus that causes COVID-19.

10 Jun 2020

Tumors cause disruption of the immune system throughout the body, study finds

Cancer treatment has advanced with the advent of immunotherapies that, in some cancers, can overcome tumors' ability to evade the immune system by suppressing local immune responses.

3 Jun 2020

Police using rubber bullets on protesters that can kill, blind or maim for life

In cities across the country, police departments have attempted to quell unrest spurred by the death of George Floyd by firing rubber bullets into crowds, even though five decades of evidence shows such weapons can disable, disfigure and even kill.

2 Jun 2020

Spleen plays a dual role in malaria vivax

Plasmodium vivax is the most widely distributed human malaria parasite, mostly outside sub-Saharan Africa, and responsible for millions of clinical cases yearly, including severe disease and death. The mechanisms by which P. vivax causes disease are not well understood.

2 Jun 2020

No specific COVID-19-linked lesions found despite extensive organ injury

A recent paper published online on the preprint server medRxiv in May 2020 reports autopsy results on COVID-19 patients. The paper concludes that there were no specific hallmark lesions of COVID-19 in any of the many organs found to be injured by the infection in patients who died of the disease.

1 Jun 2020

How susceptible are domestic animals to SARS-CoV-2?

A recent paper by Chinese researchers, published in the leading journal Science, shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) does not replicate well in dogs, pigs, chickens, and ducks; however, ferrets and cats are easily infected, and cats may transmit the virus via an airborne route.

31 May 2020

Specific immune cells induced by vaccination are early indicators of vaccine efficacy

Ludwig-Maximilians-Universität in Munich researchers have shown that a specific class of immune cells in the blood induced by vaccination is an earlier indicator of vaccine efficacy than conventional tests for neutralizing antibodies.

15 May 2020

New tool can help produce large amounts of scientific literature on COVID-19

A team of materials scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) - scientists who normally spend their time researching things like high-performance materials for thermoelectrics or battery cathodes - have built a text-mining tool in record time to help the global scientific community synthesize the mountain of scientific literature on COVID-19 being generated every day.

28 Apr 2020

EPFL scientists identify new therapeutic target for Non-Hodgkin lymphoma

Non-Hodgkin lymphoma is a group of cancers that originate in the lymph nodes and affect white blood cells of the immune system called B cells.

23 Apr 2020

Accelerating Antibody Discovery with Next-Generation Single-Cell Analysis

Accelerating antibody discovery using picodroplet technology for single cell analysis to condense discovery times down to 1-2 days.

From Fluidic Sciences and Sphere Bio 22 Apr 2020

New study raises red flags about strategy to block cancer drug resistance

Sooner or later, most cancer patients develop resistance to the very chemotherapy drugs designed to kill their cancer, forcing oncologists to seek alternatives.

17 Apr 2020

Study looks into how malaria parasite evades the immune system

The parasite causing the most severe form of human malaria uses proteins to make red blood cells sticky, making it harder for the immune system to destroy it and leading to potentially fatal blood clots. New research at the Crick has identified how the parasite may control this process.

13 Apr 2020

Where cancers spread can give specific insights on disease traits

Kidney cancers that metastasize to the pancreas have a fundamentally different biology from those that metastasize elsewhere, with characteristics that can influence successful treatment, a study led by investigators with the UT Southwestern Kidney Cancer Program suggests.

12 Apr 2020

Cancer-causing mutation also promotes inflammation

Analyses of cell signals provide insight into the origin of severe inflammatory symptoms that appear in various types of blood cancer and point to possible therapeutic approaches: In around one-fourth of patients suffering from juvenile myelomonocytic leukemia, there is evidence of mutations in the so-called KRAS gene in the leukemia cells.

8 Apr 2020