Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Sun Biomedical begins DMX-200 Phase II trial for treatment of chronic kidney disease

Sun Biomedical Limited today announced the first patient had been enrolled in a Phase II study of DMX-200, an innovative new treatment that combines two different drugs to treat chronic kidney disease.

15 Sep 2015

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Genetics researchers from Case Western Reserve School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer.

14 Sep 2015

Researchers identify new epigenetic markers for colorectal cancer

Researchers at Nanjing University, China, found new epigenetic markers for colorectal cancer which may offer a new approach for treatment.

14 Sep 2015

VEGF family biomarkers ‘promising’ tools for pulmonary hypertension diagnosis

Two members of the vascular endothelial growth factor family are highly specific and moderately sensitive for the presence of pulmonary hypertension, report researchers.

10 Sep 2015

Researchers use nanopore technology for early detection of colorectal and lung cancers

Using tiny "nanopore" scanners that can detect individual DNA molecules, Professor Amit Meller and colleagues are on the hunt for biological markers in cancer cells that may help clinicians diagnose colorectal and lung cancers at their earliest stages.

10 Sep 2015

Researchers discover potential biomarker for episodic migraine

Researchers may have discovered a new marker found in the blood for episodic migraine, according to a study published in the September 9, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology.

10 Sep 2015

New $2.8 million NIH grant to help researchers find better treatments for hemorrhagic strokes

Developing better treatments and an improved understanding of the biology behind brain injury from hemorrhagic strokes is the main goal of a three-year $2.8 million grant to the Translational Genomics Research Institute, Phoenix Children's Hospital, and Barrow Neurological Institute.

9 Sep 2015

New study reveals pivotal role of miR-506 biomarker in gastric cancer

Gastric cancer poses a significant health problem in developing countries and is typically associated with late-stage diagnosis and high mortality. A new study in The American Journal of Pathology points to a pivotal role played by the biomarker microRNA (miR)-506 in gastric cancer.

8 Sep 2015

Men with relatively unaggressive prostate tumors unlikely to develop metastatic prostate cancer

Men with relatively unaggressive prostate tumors and whose disease is carefully monitored by urologists are unlikely to develop metastatic prostate cancer or die of their cancers, according to results of a study by researchers at the Brady Urological Institute at Johns Hopkins, who analyzed survival statistics up to 15 years.

1 Sep 2015

Finerenone effective in heart failure patients with diabetes and/or chronic kidney disease

In heart failure patients with diabetes and/or chronic kidney disease, a new, non-steroidal mineralocorticoid receptor antagonist (MRA) called finerenone was no more effective than the currently approved MRA eplerenone in reducing the heart failure biomarker N-terminal pro-B-type natriuretic peptide [NT-proBNP].

1 Sep 2015

Researchers discover that vitamin D may play significant role in preventing AMD among women

Vitamin D has been studied extensively in relation to bone health as well as cancer. Now, a team led by a researcher at the University at Buffalo has discovered that vitamin D may play a significant role in eye health, specifically in the possible prevention of age-related macular degeneration, or AMD, among women who are more genetically prone to developing the sight-damaging disease.

1 Sep 2015

MACC1 gene can help predict better treatment options for patients with Klatskin carcinoma

Bile duct cancer is rare and is usually detected too late. Often only extensive liver surgery can help or, in rare cases, liver transplantation. But which patients will benefit from surgery and which will not, because their risk of cancer recurrence is too high? With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment option is best for patients with Klatskin carcinoma, one type of bile duct cancer.

1 Sep 2015

Study shows food craving may be hard-wired into the brain of overweight patients

An international group of researchers have found that food craving activates different brain networks between obese and normal weight patients.

31 Aug 2015

Cornell study reveals how obesity changes consistency of breast tissue

Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published this month in Science Translational Medicine explains how obesity changes the consistency of breast tissue in ways that are similar to tumors, thereby promoting disease.

27 Aug 2015

ASTRO awards $675,000 to seven physician-researchers to advance radiation oncology research

The American Society for Radiation Oncology has selected seven leading physician-researchers to receive a total of $675,000 in awards and grants to advance radiation oncology research. Together, the seven funding grants, including ASTRO Junior Faculty Career Research Training Award, the ASTRO Residents/Fellows in Radiation Oncology Research Seed Award and the ASTRO/Radiation Oncology Institute Comparative Effectiveness Research Award, will support studies in radiation and cancer biology, radiation physics, translational research, outcomes/health services research and comparative effectiveness research within radiation oncology.

27 Aug 2015

Research reveals why older adults who undergo general anesthesia experience postoperative delirium

Newly published research from the Department of Geriatrics and Gerontology at the Rowan University School of Osteopathic Medicine explains why up to half of older adults who undergo general anesthesia develop postoperative delirium - the sudden onset of confusion, aggression or agitated behavior that could progress to dementia. The findings indicate that older patients who are undergoing surgery may benefit from a less-potent, slower-acting anesthetic.

26 Aug 2015

Study shows significant link between macular pigment levels in the eye and cognitive function

Ongoing European Research Council-funded research at Waterford Institute of Technology's Macular Pigment Research Group is investigating the potential link between cognitive function and levels of a vital eye pigment linked to diet. The study suggests that measuring macular pigment offers potential as a biomarker of cognitive health

25 Aug 2015

Dr. Sharma receives research award from ASCO to continue study on triple-negative breast cancer

Dr. Sharma was awarded the 2015 Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology to continue her research on triple-negative breast cancer.

25 Aug 2015

Berg and University of Miami extend partnership to battle cardiac dysfunction, heart failure

Berg, a Boston-based biopharmaceutical company, and the University of Miami Leonard M. Miller School of Medicine are extending its collaboration to battle cardiac dysfunction and heart failure. According to the American Heart Association, cardiovascular disease is the leading global cause of death, accounting for 17.3 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030.

23 Aug 2015

Potential biomarker could help prevent pre-diabetic individuals from developing Type II diabetes

Virginia Tech researchers have identified a biomarker in pre-diabetic individuals that could help prevent them from developing Type II diabetes.

21 Aug 2015

Biomarker News and Research

Further Reading

Sun Biomedical begins DMX-200 Phase II trial for treatment of chronic kidney disease

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Researchers identify new epigenetic markers for colorectal cancer

VEGF family biomarkers ‘promising’ tools for pulmonary hypertension diagnosis

Researchers use nanopore technology for early detection of colorectal and lung cancers

Researchers discover potential biomarker for episodic migraine

New $2.8 million NIH grant to help researchers find better treatments for hemorrhagic strokes

New study reveals pivotal role of miR-506 biomarker in gastric cancer

Men with relatively unaggressive prostate tumors unlikely to develop metastatic prostate cancer

Finerenone effective in heart failure patients with diabetes and/or chronic kidney disease

Researchers discover that vitamin D may play significant role in preventing AMD among women

MACC1 gene can help predict better treatment options for patients with Klatskin carcinoma

Study shows food craving may be hard-wired into the brain of overweight patients

Cornell study reveals how obesity changes consistency of breast tissue

ASTRO awards $675,000 to seven physician-researchers to advance radiation oncology research

Research reveals why older adults who undergo general anesthesia experience postoperative delirium

Study shows significant link between macular pigment levels in the eye and cognitive function

Dr. Sharma receives research award from ASCO to continue study on triple-negative breast cancer

Berg and University of Miami extend partnership to battle cardiac dysfunction, heart failure

Potential biomarker could help prevent pre-diabetic individuals from developing Type II diabetes

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