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New cooling method uncovers inner workings of key iron-containing enzyme

A team of Michigan State University scientists -- using a new cooling method they created - have uncovered the inner workings of a key iron-containing enzyme, a discovery that could help researchers develop new medicines or understand how enzymes repair DNA.

27 Feb 2010

State roundup: S.C. plan would end benefits to 30,000 disabled residents; Judge bars Calif. from cutting elderly from day care; Mass. faces lawsuit on immigrant health care

Children with autism, people with spine and brain injuries and the long-term disabled in job programs are among the 30,000 people who would lose state help under a $5.1 billion spending plan approved by a House committee Thursday.

27 Feb 2010

Neurogenesis linked to drug addiction and relapse

Researchers at UT Southwestern Medical Center hope they have begun paving a new pathway in the fight against drug dependence. Their hypothesis - that increasing the normally occurring process of making nerve cells might prevent addiction - is based on a rodent study demonstrating that blocking new growth of specific brain nerve cells increases vulnerability for cocaine addiction and relapse.

27 Feb 2010

Synta Pharmaceuticals presents preclinical and clinical data of Hsp90 inhibitor STA-9090

Synta Pharmaceuticals Corp., a biopharmaceutical company focused on discovering, developing, and commercializing small molecule drugs to treat severe medical conditions, today announced that Dr. Geoffrey I. Shapiro of Dana-Farber Cancer Institute, presented preclinical and clinical data on STA-9090, a potent second-generation Hsp90 inhibitor, at IASLC (International Association for the Study of Lung Cancer) 10th Annual Targeted Therapies of the Treatment of Lung Cancer Meeting in Santa Monica, CA.

27 Feb 2010

Dabigatran as effective as warfarin in preventing subsequent strokes among atrial fibrillation patients

The drug dabigatran was as effective as the currently recommended drug – warfarin – in preventing a subsequent stroke among people with atrial fibrillation and prior stroke or transient ischemic attack – and it did so with less bleeding according to late-breaking science presented at the American Stroke Association's International Stroke Conference 2010.

27 Feb 2010

Cancer researchers assess PCI-32765 drug that targets molecular abnormalities of lymphoma cells

Cancer researchers have high hopes for a new therapy for patients with certain types of lymphoma and leukemia.

27 Feb 2010

Prevention of recurrent strokes: Antiplatelet drug cilostazol effective and safer than aspirin

The antiplatelet drug cilostazol — used in the United States to treat leg pain associated with peripheral vascular disease — was more effective and safer than aspirin at preventing recurrent strokes in a Japanese trial presented as late-breaking science at the American Stroke Association's International Stroke Conference 2010.

27 Feb 2010

Notch-blocking drug effective against brain cancer stem cells, but more than one targeted attack needed

Working with mice, Johns Hopkins scientists who tested drugs intended to halt growth of brain cancer stem cells - a small population of cells within tumors that perpetuate cancer growth - conclude that blocking these cells may be somewhat effective, but more than one targeted drug attack may be needed to get the job done.

26 Feb 2010

Librede to develop technologies for improving ion channel drug discovery and screening at CNSI incubator

Librede Inc. has joined the UCLA on-campus technology incubator space at the California NanoSystems Institute, where the startup company will work on developing technologies to improve ion channel drug discovery and screening.

26 Feb 2010

Nanotechnology to tackle side effects and drug resistance in treatment of cancer

Huixin He, associate professor, nanoscale chemistry at Rutgers University, Newark, and Tamara Minko, professor at the Rutgers Ernest Mario School of Pharmacy, have developed a nanotechnology approach that potentially could eliminate the problems of side effects and drug resistance in the treatment of cancer. Under traditional chemotherapy, cancer cells, like bacteria, can develop resistance to drug therapy, leading to a relapse of the disease.

26 Feb 2010

Idaho Health Freedom Act may have severe implications on health care system in Idaho: AARP

As the President and a bipartisan group of members of Congress come together today to discuss how to tackle the nation's growing health care crisis, Idaho Senators are poised to debate a bill tomorrow that could make the issue worse in the state. The Idaho Health Freedom Act (HB 391), taking aim at a component of a non-existent federal health care law, could wreak havoc in Idaho, while costing the state money and jobs.

26 Feb 2010

Intracranial stenting, intra-arterial tPA more effective than other urgent ischemic stroke treatments

Techniques that keep brain arteries open (intracranial stenting) or inject clot-busting drugs directly to the brain (intra-arterial tPA) may be more effective than other urgent ischemic stroke treatments, researchers said at the American Stroke Association's International Stroke Conference 2010.

26 Feb 2010

Go4Europe conference to focus on current situation of pharmaceutical companies

The 8th Go4Europe conference, held on March 15, 2010 in the Tel Aviv Hilton, will include a panel focusing on "Innovation for Pharma and Access to Finance for Biotech."

26 Feb 2010

Comprehensive development strategy yields two potential drugs that block cancer-promoting pathways

A comprehensive drug development strategy that starts with extensive screening of potential targeting agents and then narrows down to a small-molecule prototype has yielded two potential drugs that block cancer-promoting pathways in novel ways, a team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in two papers published back-to-back online at the Proceedings of the National Academies of Science.

26 Feb 2010

Current alcohol use rate for blacks aged 18 and older significantly lower than national adult average: Study

The current alcohol use rate for blacks aged 18 and older is significantly lower than the national adult average (44.3 percent versus 55.2 percent) according to a new study based on a national survey.

26 Feb 2010

Supelco launches Ascentis Express Peptide ES-C18 HPLC columns

Supelco, a division of Sigma-Aldrich®, announced today the launch of Ascentis Express Peptide ES-C18, a high-speed, high-performance liquid chromatography (HPLC) column based on a new 160 angstrom Fused-Core™ particle design. This column design exhibits very high column efficiency, providing a stable, reversed phase packing with a pore structure and pore size that is optimized for reversed-phase HPLC separations of peptides and polypeptides.

26 Feb 2010

KV Pharmaceutical makes agreement with U.S. Department of Justice to resolve investigation on ETHEX

KV Pharmaceutical Company today announced that it has reached an agreement, subject to court approval, with the United States Attorney for the Eastern District of Missouri and the Office of Consumer Litigation of the United States Department of Justice to resolve an investigation regarding certain activities of ETHEX Corporation, its generic pharmaceutical marketing and distribution subsidiary, which occurred in 2008.

26 Feb 2010

NORD lauds FDA's establishment of new position within CDER

Peter L. Saltonstall, president and CEO of the National Organization for Rare Disorders (NORD), today said the Food and Drug Administration's (FDA) announcement that it has created a new position—Associate Director for Rare Diseases—in the agency's Center for Drug Evaluation and Research's (CDER) Office of New Drugs (OND) represents an important advance for patients with rare diseases.

26 Feb 2010

Study confirms efficacy and tolerability of lacosamide for uncontrolled POS

A recent multi-center study has confirmed earlier study results that 400 mg/day of lacosamide provides a good balance of efficacy and tolerability for patients with uncontrolled partial-onset seizures (POS), and doses of 600mg/day may provide additional benefit for some patients.

26 Feb 2010

Scientists identify new way to treat castrate resistant cells in prostate cancer patients

Monash University biomedical scientists have identified a new way to treat castrate resistant cells in prostate cancer sufferers - the most common cancer in Australian men.

25 Feb 2010

Drugs News and Research

New cooling method uncovers inner workings of key iron-containing enzyme

State roundup: S.C. plan would end benefits to 30,000 disabled residents; Judge bars Calif. from cutting elderly from day care; Mass. faces lawsuit on immigrant health care

Neurogenesis linked to drug addiction and relapse

Synta Pharmaceuticals presents preclinical and clinical data of Hsp90 inhibitor STA-9090

Dabigatran as effective as warfarin in preventing subsequent strokes among atrial fibrillation patients

Cancer researchers assess PCI-32765 drug that targets molecular abnormalities of lymphoma cells

Prevention of recurrent strokes: Antiplatelet drug cilostazol effective and safer than aspirin

Notch-blocking drug effective against brain cancer stem cells, but more than one targeted attack needed

Librede to develop technologies for improving ion channel drug discovery and screening at CNSI incubator

Nanotechnology to tackle side effects and drug resistance in treatment of cancer

Idaho Health Freedom Act may have severe implications on health care system in Idaho: AARP

Intracranial stenting, intra-arterial tPA more effective than other urgent ischemic stroke treatments

Go4Europe conference to focus on current situation of pharmaceutical companies

Comprehensive development strategy yields two potential drugs that block cancer-promoting pathways

Current alcohol use rate for blacks aged 18 and older significantly lower than national adult average: Study

Supelco launches Ascentis Express Peptide ES-C18 HPLC columns

KV Pharmaceutical makes agreement with U.S. Department of Justice to resolve investigation on ETHEX

NORD lauds FDA's establishment of new position within CDER

Study confirms efficacy and tolerability of lacosamide for uncontrolled POS

Scientists identify new way to treat castrate resistant cells in prostate cancer patients

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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